Odds of ASE activity < 50 U/L under different ASE preparations at different Ab levels against E coli ASE. Results were generated applying a generalized linear model that was fitted by generalized estimating equations (GEE)
| ASE preparation . | Ab level* . | OR (activity < 50 U/L) . | Confidence limits . | P . |
|---|---|---|---|---|
| Native E coli ASE | b+ vs Ab− | 11.03 | 2.26-53.76 | .0030 |
| Ab++ vs Ab− | 61.73 | 16.98-227.27 | < .0001 | |
| Ab+++ vs Ab− | 256.41 | 26.11-2500 | < .0001 | |
| Pegylated E coli ASE | Ab+ vs Ab− | 6.36 | 2.00-20.16 | .6511 |
| Ab++ vs Ab− | 72.99 | 23.31-227.27 | .0017 | |
| Ab+++ vs Ab− | < .0001 | |||
| Erwinia ASE | Ab+ vs Ab− | .2797 | ||
| Ab++ vs Ab− | .2209 | |||
| Ab+++ vs Ab− | .2123 |
| ASE preparation . | Ab level* . | OR (activity < 50 U/L) . | Confidence limits . | P . |
|---|---|---|---|---|
| Native E coli ASE | b+ vs Ab− | 11.03 | 2.26-53.76 | .0030 |
| Ab++ vs Ab− | 61.73 | 16.98-227.27 | < .0001 | |
| Ab+++ vs Ab− | 256.41 | 26.11-2500 | < .0001 | |
| Pegylated E coli ASE | Ab+ vs Ab− | 6.36 | 2.00-20.16 | .6511 |
| Ab++ vs Ab− | 72.99 | 23.31-227.27 | .0017 | |
| Ab+++ vs Ab− | < .0001 | |||
| Erwinia ASE | Ab+ vs Ab− | .2797 | ||
| Ab++ vs Ab− | .2209 | |||
| Ab+++ vs Ab− | .2123 |
Results were generated applying a generalized linear model that was fitted by generalized estimating equations.
ASE indicates antileukemic enzyme asparaginase; and OR, odds ratio.
Ab−: < 6.25 AU/mL; Ab+: 6.25-20 AU/mL; Ab++: 20-200 AU/mL; Ab+++: > 200 U/mL.