Chromosomal aberrations in MSCs
| Patient no.* . | Diagnosis . | Cytogenetic markers . | |
|---|---|---|---|
| HCs . | MSCs . | ||
| 0806 | AML M2 | 46,XX[25] | t(1;2)(p32;q31)[15] |
| 1282 | AML M5 | 47,XY,+8,t(11;19)(q23;p13.1)[25] | t(1;6)(p32;p12)[23] |
| 0734 | AML M1 | 46,XX,t(11;19)(q23;p13.1)[21]/46,XX[4] | del(7)(q11.2q32)[9] |
| 0717 | RA | 46,XX[25] | del(7)(q22)[3] |
| 0214 | s-AML M6 | 46,XY,del(5)(q13q32)[25] | del(7)(q22)[3] |
| 1068 | AML M5 | 46,XY[25] | t(3;20)(p13;p11.2)[15] |
| 0600 | RAEB II | 47,XY,+8[25] | inv(X)(q12p22)[16] |
| 1150 | s-AML M4 | 45,XY,−7[20]/46,XY[5] | del(11)(q23)[2] |
| 0589 | AML M4 | 46,XY[25] | del(13)(q12q22)[6] |
| 0204 | s-AML M1 | 46,XY,add(1)(p36),−4,der(5),der(7), der(9),add(12)(p13),der(17),+21[25] | del(15)(q14)[4] |
| 1398 | s-AML M2 | 46,XY[25], FLT3-ITD mutation | +5[4] |
| 0816 | RAEB II | 46,XX,del(7)(q31)[25] | +5[14] |
| 0645 | RCMD-RS | 46,XY[25] | −4[6] |
| 0752 | s-AML M1 | 46,XX,del(5)(q22q35)[8]/47,XX,idem, +21[3]/48,XX,idem,+21,+mar[6] | −X[12] |
| 0789 | RAEB I | 46,XY[25] | −Y[6] |
| Patient no.* . | Diagnosis . | Cytogenetic markers . | |
|---|---|---|---|
| HCs . | MSCs . | ||
| 0806 | AML M2 | 46,XX[25] | t(1;2)(p32;q31)[15] |
| 1282 | AML M5 | 47,XY,+8,t(11;19)(q23;p13.1)[25] | t(1;6)(p32;p12)[23] |
| 0734 | AML M1 | 46,XX,t(11;19)(q23;p13.1)[21]/46,XX[4] | del(7)(q11.2q32)[9] |
| 0717 | RA | 46,XX[25] | del(7)(q22)[3] |
| 0214 | s-AML M6 | 46,XY,del(5)(q13q32)[25] | del(7)(q22)[3] |
| 1068 | AML M5 | 46,XY[25] | t(3;20)(p13;p11.2)[15] |
| 0600 | RAEB II | 47,XY,+8[25] | inv(X)(q12p22)[16] |
| 1150 | s-AML M4 | 45,XY,−7[20]/46,XY[5] | del(11)(q23)[2] |
| 0589 | AML M4 | 46,XY[25] | del(13)(q12q22)[6] |
| 0204 | s-AML M1 | 46,XY,add(1)(p36),−4,der(5),der(7), der(9),add(12)(p13),der(17),+21[25] | del(15)(q14)[4] |
| 1398 | s-AML M2 | 46,XY[25], FLT3-ITD mutation | +5[4] |
| 0816 | RAEB II | 46,XX,del(7)(q31)[25] | +5[14] |
| 0645 | RCMD-RS | 46,XY[25] | −4[6] |
| 0752 | s-AML M1 | 46,XX,del(5)(q22q35)[8]/47,XX,idem, +21[3]/48,XX,idem,+21,+mar[6] | −X[12] |
| 0789 | RAEB I | 46,XY[25] | −Y[6] |
RCMD indicates refractory cytopenia with multilineage dysplasia; and RCMD-RS, RCMD with ringed sideroblasts.
For the patient sample.