Table 1

Clinicopathologic data of VRL patients from test cohort

Age (y)SexInitial diagnosisCommentsMYD88 statusB-cell clonalityCellularity
VRL with CNS involvement        
 1A 71 f DLBCL  p.L265P mono 2 
 1B   DLBCL  p.L265P poly 2 
 2 55 f DLBCL  WT mono 2 
 3A 58 m DLBCL  WT mono 1 
 3B   DLBCL  WT mono — 
 4 77 f DLBCL  WT oligo 2 
 5A 82 f Reactive  WT* NE 2 
 5B   DLBCL  p.P258L c.772 C>T mono 2 
 6A 62 f Reactive DLBCL diagnosed in CNS biopsy, history of breast cancer p.L265P poly 2 
 6B   Reactive  p.L265P poly 2 
 6C   Reactive  p.L265P poly NE 
 7 57 f Reactive History of Hodgkin lymphoma p.L265P poly 1 
 8 45 f Suspicious for lymphoma  p.L265P mono 1 
Primary VRL without CNS involvement        
 9 70 f DLBCL  p.L265P mono 1 
 10 76 f DLBCL  p.L265P mono 1 
 11 49 f DLBCL  p.L265P NE 3 
 12 72 m DLBCL  p.L265P mono 1 
 13 72 m DLBCL  p.L265P mono 1 
 14 72 m DLBCL  WT mono 2 
 15 44 f Suspicious for lymphoma DLBCL diagnosed in choroid biopsy WT mono 1 
 16 80 f Suspicious for lymphoma DLBCL diagnosed in choroid biopsy WT mono 1 
 17 85 f Suspicious for lymphoma  p.L265P mono 2 
 18 86 f Reactive  p.L265P NE 1 
Secondary VRL without CNS involvement        
 19† 72 m DLBCL Testicular DLBCL 10 y previously p.L265P mono 1 
 20 73 m Intraocular involvement by MZL MZL of the conjunctiva WT mono 1 
 21† 53 m Suspicious for lymphoma Testicular DLBCL 2 y previously p.L265P mono 1 
Age (y)SexInitial diagnosisCommentsMYD88 statusB-cell clonalityCellularity
VRL with CNS involvement        
 1A 71 f DLBCL  p.L265P mono 2 
 1B   DLBCL  p.L265P poly 2 
 2 55 f DLBCL  WT mono 2 
 3A 58 m DLBCL  WT mono 1 
 3B   DLBCL  WT mono — 
 4 77 f DLBCL  WT oligo 2 
 5A 82 f Reactive  WT* NE 2 
 5B   DLBCL  p.P258L c.772 C>T mono 2 
 6A 62 f Reactive DLBCL diagnosed in CNS biopsy, history of breast cancer p.L265P poly 2 
 6B   Reactive  p.L265P poly 2 
 6C   Reactive  p.L265P poly NE 
 7 57 f Reactive History of Hodgkin lymphoma p.L265P poly 1 
 8 45 f Suspicious for lymphoma  p.L265P mono 1 
Primary VRL without CNS involvement        
 9 70 f DLBCL  p.L265P mono 1 
 10 76 f DLBCL  p.L265P mono 1 
 11 49 f DLBCL  p.L265P NE 3 
 12 72 m DLBCL  p.L265P mono 1 
 13 72 m DLBCL  p.L265P mono 1 
 14 72 m DLBCL  WT mono 2 
 15 44 f Suspicious for lymphoma DLBCL diagnosed in choroid biopsy WT mono 1 
 16 80 f Suspicious for lymphoma DLBCL diagnosed in choroid biopsy WT mono 1 
 17 85 f Suspicious for lymphoma  p.L265P mono 2 
 18 86 f Reactive  p.L265P NE 1 
Secondary VRL without CNS involvement        
 19† 72 m DLBCL Testicular DLBCL 10 y previously p.L265P mono 1 
 20 73 m Intraocular involvement by MZL MZL of the conjunctiva WT mono 1 
 21† 53 m Suspicious for lymphoma Testicular DLBCL 2 y previously p.L265P mono 1 

CNS, central nervous system; DLBCL, diffuse large B-cell lymphoma; mono, monoclonal; MZL, extranodal marginal zone B-cell lymphoma; NE, not evaluable; oligo, oligoclonal; poly, polyclonal; VRL, vitreoretinal lymphoma; WT, wild type.

A and B denote vitreous samples obtained at different time points.

Cellularity: 1, low; 2, medium; 3, high.

*

This sample was WT for the L265P mutation and also showed WT sequence for MYD88 exons 3 and 4, probably because of low tumor cell content.

†

The primary testicular lymphomas of both patients showed the presence of MYD88 L265P mutation.

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