Patient characteristics
| ID no. . | Sex . | Age, y . | IgHV . | Genetic aberration . | p53 . | Rai stage . | Previous therapy . |
|---|---|---|---|---|---|---|---|
| 1 | F | 49 | Mut | del13q14 | Functional | 1 | None |
| 2 | F | 64 | Mut | None | Functional | 2 | ClbP |
| 3 | M | 59 | Mut | None | Functional | 3 | None |
| 4 | M | 64 | UM | del13q14, del5q15 | Functional | 1 | None |
| 5 | F | 44 | Mut | del13q14 | Functional | 2 | Clb |
| 6 | M | 75 | Mut | del11q22 | Functional | 1 | None |
| 7 | M | 64 | Mut | del13q14, del5q15, t(14q32) | Functional | 3 | Clb |
| 8 | F | 75 | Mut | None | Functional | 4 | None |
| 9 | M | 65 | Mut | del13q14, t(14q32) | Functional | 4 | Clb |
| 10 | M | 60 | UM | trisomie 12 | ND | 0 | Clb |
| 11 | M | 51 | UM | trisomie 12 | Functional | 1 | Clb |
| 12 | M | 77 | UM | del13q14, del11q22, del17p13 | Functional | 2 | ClbP |
| 13 | M | 74 | UM | None | Functional | 2 | None |
| 14 | F | 89 | Mut | None | Functional | 0 | None |
| 15 | M | 59 | Mut | del13q14, del11q22 | Functional | 2 | Clb, F |
| 16 | F | 82 | Mut | None | Functional | 1 | None |
| 17 | M | 77 | Mut | del11q22 | Functional | 2 | None |
| 18 | F | 85 | Mut | None | ND | 1 | None |
| 19 | F | 62 | Mut | ND | ND | 1 | None |
| 20 | M | 59 | Mut | None | Functional | 3 | None |
| 21 | M | 51 | UM | trisomie 12 | Functional | 1 | Clb |
| 22 | M | 44 | UM | None | Functional | 2 | None |
| 23 | M | 66 | UM | ND | ND | 0 | None |
| 24 | M | 59 | UM | ND | Functional | 0 | None |
| 25 | M | 60 | UM | del11q22 | Functional | 2 | Clb, Ofa, FCR + P |
| 26 | F | 59 | UM | del17p13 67%, t(14q32) | Nonfunctional | 1 | None |
| 27 | M | 83 | Mut | del17p13 53%, del13q14 | Nonfunctional | 4 | Clb |
| 28 | M | 54 | Mut | ND | Nonfunctional | 1 | None |
| 29 | V | 63 | Mut | del13q14 | Functional | ND | ND |
| 30 | M | 58 | Mut | ND | Functional | 3 | ND |
| 31 | M | 59 | Mut | ND | Functional | 3 | ND |
| 32 | M | 63 | Mut | del13q14, del14q32 | Functional | 3 | ND |
| ID no. . | Sex . | Age, y . | IgHV . | Genetic aberration . | p53 . | Rai stage . | Previous therapy . |
|---|---|---|---|---|---|---|---|
| 1 | F | 49 | Mut | del13q14 | Functional | 1 | None |
| 2 | F | 64 | Mut | None | Functional | 2 | ClbP |
| 3 | M | 59 | Mut | None | Functional | 3 | None |
| 4 | M | 64 | UM | del13q14, del5q15 | Functional | 1 | None |
| 5 | F | 44 | Mut | del13q14 | Functional | 2 | Clb |
| 6 | M | 75 | Mut | del11q22 | Functional | 1 | None |
| 7 | M | 64 | Mut | del13q14, del5q15, t(14q32) | Functional | 3 | Clb |
| 8 | F | 75 | Mut | None | Functional | 4 | None |
| 9 | M | 65 | Mut | del13q14, t(14q32) | Functional | 4 | Clb |
| 10 | M | 60 | UM | trisomie 12 | ND | 0 | Clb |
| 11 | M | 51 | UM | trisomie 12 | Functional | 1 | Clb |
| 12 | M | 77 | UM | del13q14, del11q22, del17p13 | Functional | 2 | ClbP |
| 13 | M | 74 | UM | None | Functional | 2 | None |
| 14 | F | 89 | Mut | None | Functional | 0 | None |
| 15 | M | 59 | Mut | del13q14, del11q22 | Functional | 2 | Clb, F |
| 16 | F | 82 | Mut | None | Functional | 1 | None |
| 17 | M | 77 | Mut | del11q22 | Functional | 2 | None |
| 18 | F | 85 | Mut | None | ND | 1 | None |
| 19 | F | 62 | Mut | ND | ND | 1 | None |
| 20 | M | 59 | Mut | None | Functional | 3 | None |
| 21 | M | 51 | UM | trisomie 12 | Functional | 1 | Clb |
| 22 | M | 44 | UM | None | Functional | 2 | None |
| 23 | M | 66 | UM | ND | ND | 0 | None |
| 24 | M | 59 | UM | ND | Functional | 0 | None |
| 25 | M | 60 | UM | del11q22 | Functional | 2 | Clb, Ofa, FCR + P |
| 26 | F | 59 | UM | del17p13 67%, t(14q32) | Nonfunctional | 1 | None |
| 27 | M | 83 | Mut | del17p13 53%, del13q14 | Nonfunctional | 4 | Clb |
| 28 | M | 54 | Mut | ND | Nonfunctional | 1 | None |
| 29 | V | 63 | Mut | del13q14 | Functional | ND | ND |
| 30 | M | 58 | Mut | ND | Functional | 3 | ND |
| 31 | M | 59 | Mut | ND | Functional | 3 | ND |
| 32 | M | 63 | Mut | del13q14, del14q32 | Functional | 3 | ND |
Mut indicates mutated IgHV genes; UM, unmutated IgHV genes; Clb, chlorambucil; ClbP, chlorambucil + prednisone; F, fludarabine; FCR, fludarabine, cyclophosphamide, rituximab; Ofa, ofatumumab; P, prednisone; and ND, not determined.