Risk factor analysis for CNS relapse in the entire cohort (N = 625)
| Factor . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| B-symptoms* | 2.20 (0.93-5.21) | .073 | — | — |
| Skin | 4.33 (1.75-10.7) | .002 | 3.51 (1.26-9.74) | .016 |
| Pleural involvement | 3.27 (0.99-10.8) | .053 | — | — |
| Testicular involvement | 5.61 (0.76-41.4) | .091 | — | — |
| Gastrointestinal involvement | 2.90 (1.28-6.60) | .011 | 3.06 (1.30-7.18) | .010 |
| >1 Extranodal involvement | 4.05 (1.83-8.98) | .001 | 2.60 (1.07-6.29) | .035 |
| Lactate dehydrogenase >ULN* | 2.16 (0.91-5.10) | .081 | — | — |
| Factor . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| B-symptoms* | 2.20 (0.93-5.21) | .073 | — | — |
| Skin | 4.33 (1.75-10.7) | .002 | 3.51 (1.26-9.74) | .016 |
| Pleural involvement | 3.27 (0.99-10.8) | .053 | — | — |
| Testicular involvement | 5.61 (0.76-41.4) | .091 | — | — |
| Gastrointestinal involvement | 2.90 (1.28-6.60) | .011 | 3.06 (1.30-7.18) | .010 |
| >1 Extranodal involvement | 4.05 (1.83-8.98) | .001 | 2.60 (1.07-6.29) | .035 |
| Lactate dehydrogenase >ULN* | 2.16 (0.91-5.10) | .081 | — | — |
Missing values: B-symptoms (n = 22); lactate dehydrogenase (n = 36).