Table 3 Allele frequencies of HLA-A,... | American Society of Hematology

Table 3

Allele frequencies of HLA-A, HLA-B, and HLA-DR alleles with (nearly) significant difference between controls and EBV⁺ or EBV⁻ cHL subgroups

	Controls		EBV⁺ cHL		EBV⁻ cHL		Controls vs EBV⁺ (P)	Controls vs EBV⁻ (P)
	n	%	n	%	n	%	Controls vs EBV⁺ (P)	Controls vs EBV⁻ (P)
HLA-A1	2667	18.8	52	33.3	85	13.0	< .00001†	NS
HLA-A2	4828	34.0	25	16.0	153	33.0	< .00001†	NS
HLA-A68(28)	124	0.9	5	3.2	26	5.6	.0021†	< .000001†
HLA-B37	277	1.9	13	8.4	10	2.2	< .000001†	NS
HLA-B51(5)*	745	5.1	14	7.4	33	9.1	NS	NS
HLA-B60(40)	1037	7.1	8	5.2	15	3.4	NS	.0022‡
HLA-DR4	2146	18.1	26	16.7	55	11.9	NS	.00063†
HLA-DR7	1320	11.1	7	4.5	26	5.6	NS	.00019†
HLA-DR10	118	1.0	6	3.8	5	1.1	.00047†	NS
HLA-DR11(5)	87	0.7	7	4.5	60	13.0	< .000001†	< .000001†
HLA-DR15(2)	1690	14.3	27	17.3	104	22.5	NS	.000001†

	Controls		EBV⁺ cHL		EBV⁻ cHL		Controls vs EBV⁺ (P)	Controls vs EBV⁻ (P)
	n	%	n	%	n	%	Controls vs EBV⁺ (P)	Controls vs EBV⁻ (P)
HLA-A1	2667	18.8	52	33.3	85	13.0	< .00001†	NS
HLA-A2	4828	34.0	25	16.0	153	33.0	< .00001†	NS
HLA-A68(28)	124	0.9	5	3.2	26	5.6	.0021†	< .000001†
HLA-B37	277	1.9	13	8.4	10	2.2	< .000001†	NS
HLA-B51(5)*	745	5.1	14	7.4	33	9.1	NS	NS
HLA-B60(40)	1037	7.1	8	5.2	15	3.4	NS	.0022‡
HLA-DR4	2146	18.1	26	16.7	55	11.9	NS	.00063†
HLA-DR7	1320	11.1	7	4.5	26	5.6	NS	.00019†
HLA-DR10	118	1.0	6	3.8	5	1.1	.00047†	NS
HLA-DR11(5)	87	0.7	7	4.5	60	13.0	< .000001†	< .000001†
HLA-DR15(2)	1690	14.3	27	17.3	104	22.5	NS	.000001†

NS indicates not significant.

HLA-B51 is included because it had significantly different frequencies in the total group of cases compared with controls (Table 2).

Significant difference (P < .001).

Suggestive difference (P < .003).