Relapsed patient information with R665W mutation in PLCG2
| . | . | . | . | Baseline . | Relapse . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|
| Number . | Patient ID . | Days on ibrutinib . | AA change . | Coverage . | Variant frequency (%) . | Coverage . | Variant frequency (%) . | IgVH . | Del(17p) . |
| R-1 | 0002 | 511 | R665W | 870 | 0 | 9977 | 5.5 | U | NA |
| R-2 | 1140* | 505 | R665W | 3465 | 0 | 2781 | 2 | U | Positive |
| R-3 | 0605 | 673 | R665W | 3230 | 0 | 9252 | 45 | M | Positive |
| . | . | . | . | Baseline . | Relapse . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|
| Number . | Patient ID . | Days on ibrutinib . | AA change . | Coverage . | Variant frequency (%) . | Coverage . | Variant frequency (%) . | IgVH . | Del(17p) . |
| R-1 | 0002 | 511 | R665W | 870 | 0 | 9977 | 5.5 | U | NA |
| R-2 | 1140* | 505 | R665W | 3465 | 0 | 2781 | 2 | U | Positive |
| R-3 | 0605 | 673 | R665W | 3230 | 0 | 9252 | 45 | M | Positive |
AA, amino acid; M, mutated status of IgVH; NA, non-detected, U, unmutated status of IgVH.
Also had acquired C481S mutation in BTK at relapse.