Relationship of BCOR disruptive mutations with NPM1, FLT3-ITD, DNMT3A, and RUNX1 mutations
| Block . | BCOR status . | Patients, n . | P* . | ||
|---|---|---|---|---|---|
| Total (I+G) | NPM1 wt | NPM1 mut | |||
| A | Mutated | 26 | 24 | 2 | < .001 |
| Wild-type | 384 | 189 | 195 | ||
| Total (I) | NPM1 wt | NPM1 mut | |||
| A1 | Mutated | 10 | 9 | 1 | .006 |
| Wild-type | 240 | 102 | 138 | ||
| Total (G) | NPM1 wt | NPM1 mut | |||
| A2 | Mutated | 16 | 15 | 1 | .01 |
| Wild-type | 144 | 87 | 57 | ||
| Total (I) | NPM1 wt/FLT3 wt | NPM1 wt/FLT3-ITD | |||
| B | Mutated | 10 | 10 | 0 | .2 |
| Wild-type | 96 | 77 | 19 | ||
| Total (I + G) | NPM1 wt/DNMT3A wt | NPM1 wt/DNM3A mut | |||
| C | Mutated | 23 | 13 | 10 | .001 |
| Wild-type | 172 | 148 | 24 | ||
| Total (I) | NPM1 wt/DNMT3A wt | NPM1 wt/DNMT3A mut | |||
| C1 | Mutated | 9 | 5 | 4 | .063 |
| Wild-type | 102 | 85 | 17 | ||
| Total (G) | NPM1 wt/DNMT3A wt | NPM1 wt/DNMT3A mut | |||
| C2 | Mutated | 14 | 8 | 6 | .006 |
| Wild-type | 70 | 63 | 7 | ||
| Total (G) | NPM1 wt/RUNX1 wt | NPM1 wt/RUNX1 mut | |||
| D | Mutated | 18† | 10 | 8 | .07 |
| Wild-type | 86 | 67 | 19 | ||
| Block . | BCOR status . | Patients, n . | P* . | ||
|---|---|---|---|---|---|
| Total (I+G) | NPM1 wt | NPM1 mut | |||
| A | Mutated | 26 | 24 | 2 | < .001 |
| Wild-type | 384 | 189 | 195 | ||
| Total (I) | NPM1 wt | NPM1 mut | |||
| A1 | Mutated | 10 | 9 | 1 | .006 |
| Wild-type | 240 | 102 | 138 | ||
| Total (G) | NPM1 wt | NPM1 mut | |||
| A2 | Mutated | 16 | 15 | 1 | .01 |
| Wild-type | 144 | 87 | 57 | ||
| Total (I) | NPM1 wt/FLT3 wt | NPM1 wt/FLT3-ITD | |||
| B | Mutated | 10 | 10 | 0 | .2 |
| Wild-type | 96 | 77 | 19 | ||
| Total (I + G) | NPM1 wt/DNMT3A wt | NPM1 wt/DNM3A mut | |||
| C | Mutated | 23 | 13 | 10 | .001 |
| Wild-type | 172 | 148 | 24 | ||
| Total (I) | NPM1 wt/DNMT3A wt | NPM1 wt/DNMT3A mut | |||
| C1 | Mutated | 9 | 5 | 4 | .063 |
| Wild-type | 102 | 85 | 17 | ||
| Total (G) | NPM1 wt/DNMT3A wt | NPM1 wt/DNMT3A mut | |||
| C2 | Mutated | 14 | 8 | 6 | .006 |
| Wild-type | 70 | 63 | 7 | ||
| Total (G) | NPM1 wt/RUNX1 wt | NPM1 wt/RUNX1 mut | |||
| D | Mutated | 18† | 10 | 8 | .07 |
| Wild-type | 86 | 67 | 19 | ||
I indicates the Italian unselected CN-AML series; G, German selected CN-AML series comprising: 82 patients with the genotype NPM1wt/CEBPAwt/IDH1wt/FLT3-ITD– negative/MLL-PTD–negative, 58 cases with NPM1 mutations, 10 cases with MLL-PTD, and 10 selected cases with biallelic CEBPA mutations; wt, wild-type; and mut, mutated.
By Fisher exact test.
Including 3 NPM1wt/BCOR-mut cases of the Italian series analyzed for RUNX1 (2 mutated and 1 wild-type).