Nomenclature of HLA alleles
Nomenclature . | Indication . |
---|---|
HLA | The HLA region and prefix for an HLA gene |
HLA-DRB1 | A particular HLA locus, ie, DRB1 |
HLA-DRB1*13 | A group of alleles that encode the DR13 antigen or sequence homology to other DRB1*13 alleles |
HLA-DRB1*13:01 | A specific HLA allele |
HLA-DRB1*13:01:02 | An allele that differs by a synonymous mutation from DRB1*13:01:01 |
HLA-DRB1*13:01:01:02 | An allele that contains a mutation outside the coding region from DRB1*13:01:01:01 |
HLA-A*24:09N | A “null” allele, an allele that is not expressed |
HLA-A*30:14L | An allele encoding a protein with significantly reduced or “Low” cell surface expression |
HLA-A*24:02:01:02L | An allele encoding a protein with significantly reduced or “Low” cell surface expression, where the mutation is found outside the coding region |
HLA-B*44:02:01:02S | An allele encoding a protein that is expressed as a “Secreted” molecule only |
HLA-A*32:11Q | An allele that has a mutation that has previously been shown to have a significant effect on cell surface expression, but where this has not been confirmed and its expression remains “Questionable” |
Nomenclature . | Indication . |
---|---|
HLA | The HLA region and prefix for an HLA gene |
HLA-DRB1 | A particular HLA locus, ie, DRB1 |
HLA-DRB1*13 | A group of alleles that encode the DR13 antigen or sequence homology to other DRB1*13 alleles |
HLA-DRB1*13:01 | A specific HLA allele |
HLA-DRB1*13:01:02 | An allele that differs by a synonymous mutation from DRB1*13:01:01 |
HLA-DRB1*13:01:01:02 | An allele that contains a mutation outside the coding region from DRB1*13:01:01:01 |
HLA-A*24:09N | A “null” allele, an allele that is not expressed |
HLA-A*30:14L | An allele encoding a protein with significantly reduced or “Low” cell surface expression |
HLA-A*24:02:01:02L | An allele encoding a protein with significantly reduced or “Low” cell surface expression, where the mutation is found outside the coding region |
HLA-B*44:02:01:02S | An allele encoding a protein that is expressed as a “Secreted” molecule only |
HLA-A*32:11Q | An allele that has a mutation that has previously been shown to have a significant effect on cell surface expression, but where this has not been confirmed and its expression remains “Questionable” |
The table was adapted from one kindly provided by Prof Steven Marsh, Anthony Nolan Research Institute, London, United Kingdom (www.hla.alleles.org).