Table 1

Nomenclature of HLA alleles

NomenclatureIndication
HLA The HLA region and prefix for an HLA gene 
HLA-DRB1 A particular HLA locus, ie, DRB1 
HLA-DRB1*13 A group of alleles that encode the DR13 antigen or sequence homology to other DRB1*13 alleles 
HLA-DRB1*13:01 A specific HLA allele 
HLA-DRB1*13:01:02 An allele that differs by a synonymous mutation from DRB1*13:01:01 
HLA-DRB1*13:01:01:02 An allele that contains a mutation outside the coding region from DRB1*13:01:01:01 
HLA-A*24:09N A “null” allele, an allele that is not expressed 
HLA-A*30:14L An allele encoding a protein with significantly reduced or “Low” cell surface expression 
HLA-A*24:02:01:02L An allele encoding a protein with significantly reduced or “Low” cell surface expression, where the mutation is found outside the coding region 
HLA-B*44:02:01:02S An allele encoding a protein that is expressed as a “Secreted” molecule only 
HLA-A*32:11Q An allele that has a mutation that has previously been shown to have a significant effect on cell surface expression, but where this has not been confirmed and its expression remains “Questionable” 
NomenclatureIndication
HLA The HLA region and prefix for an HLA gene 
HLA-DRB1 A particular HLA locus, ie, DRB1 
HLA-DRB1*13 A group of alleles that encode the DR13 antigen or sequence homology to other DRB1*13 alleles 
HLA-DRB1*13:01 A specific HLA allele 
HLA-DRB1*13:01:02 An allele that differs by a synonymous mutation from DRB1*13:01:01 
HLA-DRB1*13:01:01:02 An allele that contains a mutation outside the coding region from DRB1*13:01:01:01 
HLA-A*24:09N A “null” allele, an allele that is not expressed 
HLA-A*30:14L An allele encoding a protein with significantly reduced or “Low” cell surface expression 
HLA-A*24:02:01:02L An allele encoding a protein with significantly reduced or “Low” cell surface expression, where the mutation is found outside the coding region 
HLA-B*44:02:01:02S An allele encoding a protein that is expressed as a “Secreted” molecule only 
HLA-A*32:11Q An allele that has a mutation that has previously been shown to have a significant effect on cell surface expression, but where this has not been confirmed and its expression remains “Questionable” 

The table was adapted from one kindly provided by Prof Steven Marsh, Anthony Nolan Research Institute, London, United Kingdom (www.hla.alleles.org).

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