Multivariate analyses for EFS and OS
| Factor . | EFS . | OS . | ||||
|---|---|---|---|---|---|---|
| HR of event . | 95% CI . | P . | HR of death . | 95% CI . | P . | |
| All patients (209 patients)* | 0.52 | 0.35-0.77 | .001 | 0.47 | 0.30-0.72 | .001 |
| GRAALL protocols† | ||||||
| N/F mutation | 0.54 | 0.37-0.81 | .002 | 0.53 | 0.34-0.83 | .006 |
| TLX1 overexpression | 0.52 | 0.29-0.97 | .038 | 0.42 | 0.19-0.93 | .032 |
| GRAALL patients (135 patients)‡ | 0.42 | 0.24-0.73 | .002 | 0.36 | 0.19-0.70 | .002 |
| N/F mutation | ||||||
| TLX1 overexpression | 0.41 | 0.18-0.99 | .05 | § | ||
| Age > 35 years | 1.78 | 1.01-3.12 | .045 | § | ||
| Factor . | EFS . | OS . | ||||
|---|---|---|---|---|---|---|
| HR of event . | 95% CI . | P . | HR of death . | 95% CI . | P . | |
| All patients (209 patients)* | 0.52 | 0.35-0.77 | .001 | 0.47 | 0.30-0.72 | .001 |
| GRAALL protocols† | ||||||
| N/F mutation | 0.54 | 0.37-0.81 | .002 | 0.53 | 0.34-0.83 | .006 |
| TLX1 overexpression | 0.52 | 0.29-0.97 | .038 | 0.42 | 0.19-0.93 | .032 |
| GRAALL patients (135 patients)‡ | 0.42 | 0.24-0.73 | .002 | 0.36 | 0.19-0.70 | .002 |
| N/F mutation | ||||||
| TLX1 overexpression | 0.41 | 0.18-0.99 | .05 | § | ||
| Age > 35 years | 1.78 | 1.01-3.12 | .045 | § | ||
By backward stepwise selection from the full 6-covariate logistic regression model (see “Methods”).
GRAALA-2003 or GRAALL-2005 versus LALA-94.
By backward stepwise selection from the full 7-covariate logistic regression model (see “Methods”).
These 2 covariates were removed from the model with a P value of .11 and .15 for TLX1 overexpression and age ≥ 35, respectively.