Demographic and baseline characteristics of the 2 groups
| . | 30 U/kg/infusion (n = 15) . | 60 U/kg/infusion (n = 16) . |
|---|---|---|
| Mean age, y, ± SD at entry (range) | 36.3 ± 12.2 (19-74) | 36.0 ± 12.2 (19-58) |
| Male:female | 7:8 | 8:8 |
| Ashkenazi Jewish:non-Jewish | 6:9 | 4:12 |
| N370S homozygous:other genotype | 7:8 | 6:10 |
| Mean spleen volume, mL (range) | 2134 (886-4901) | 2117 (914-5418) |
| Mean spleen volume, MN* (range) | 15 (8-35) | 17 (8-54) |
| Mean liver volume, mL (range) | 2880 (2282-5096) | 2481 (1758-3297) |
| Mean liver volume, MN* (range) | 1.7 (1.4-2.9) | 1.6 (0.9-2.6) |
| Mean hemoglobin: g/dL (range) | 12.2 (7.9-14.6) | 11.4 (5.5-16.0) |
| Mean platelets, /mm3 (range) | 75 320 (28 000-163 000†) | 65 038 (28 000-134 000†) |
| Mean chitotriosidase, nmol/mL/h (range) | 28 158 (7791-50 024) | 24 702 (4639-66 628) |
| . | 30 U/kg/infusion (n = 15) . | 60 U/kg/infusion (n = 16) . |
|---|---|---|
| Mean age, y, ± SD at entry (range) | 36.3 ± 12.2 (19-74) | 36.0 ± 12.2 (19-58) |
| Male:female | 7:8 | 8:8 |
| Ashkenazi Jewish:non-Jewish | 6:9 | 4:12 |
| N370S homozygous:other genotype | 7:8 | 6:10 |
| Mean spleen volume, mL (range) | 2134 (886-4901) | 2117 (914-5418) |
| Mean spleen volume, MN* (range) | 15 (8-35) | 17 (8-54) |
| Mean liver volume, mL (range) | 2880 (2282-5096) | 2481 (1758-3297) |
| Mean liver volume, MN* (range) | 1.7 (1.4-2.9) | 1.6 (0.9-2.6) |
| Mean hemoglobin: g/dL (range) | 12.2 (7.9-14.6) | 11.4 (5.5-16.0) |
| Mean platelets, /mm3 (range) | 75 320 (28 000-163 000†) | 65 038 (28 000-134 000†) |
| Mean chitotriosidase, nmol/mL/h (range) | 28 158 (7791-50 024) | 24 702 (4639-66 628) |