OS and TTFT analysis for single and combined cluster groups
| Characteristic . | No. Total . | No. Expired . | No. Treated . | OS . | TTFT . | ||
|---|---|---|---|---|---|---|---|
| Median, y (95% CI) . | P* . | Median, y (95% CI) . | P* . | ||||
| All patients | 84 | 31 | 42 | 16.9 (14.4, —)† | 8.05 (6.8, 21.7) | ||
| CL1 | |||||||
| > Median | 32 | 18 | 21 | 12.5 (10, 21.8) | .013 | 7.6 (3.8, 20.9) | .2196 |
| < Median | 32 | 6 | 15 | — (14.5, —) | 9.6 (7.0, —) | ||
| CL2 | |||||||
| > Median | 32 | 12 | 17 | 16.9 (12.5, —) | .518 | 9.6 (6.8, 21.7) | .110 |
| < Median | 32 | 12 | 19 | 14.5 (10.6, —) | 7.9 (2.8, —) | ||
| CL3 | |||||||
| > Median | 32 | 7 | 15 | 21.8 (16.9, —) | .025 | 20.9 (7.6, 21.7) | .0604 |
| < Median | 32 | 17 | 21 | 14.4 (10.6, 16.3) | 7.0 (2.9, 9.4) | ||
| CL1/CL2 combined group | |||||||
| CL1HI CL2LO | 12 | 7 | 10 | 10.6 (8.6, —) | .0209 | 2.8 (0.6, 5.4) | .0002 |
| CL1HICL2HI | 20 | 11 | 11 | 16.3 (9.8,) | 9.4 (6.8, 21.7) | ||
| CL1LOCL2LO | 20 | 5 | 9 | — (14.4, —) | 9.0 (3.9, —) | ||
| CL1LOCL2HI | 12 | 1 | 6 | — (—) | 9.6 (3.2, —) | ||
| CL1/CL3 combined group | |||||||
| CL1HICL3LO | 14 | 11 | 12 | 11.2 (8.6, 15.3) | .0023 | 3.8 (1.3, 6.8) | .0107 |
| CL1HICL3HI | 18 | 7 | 9 | 21.8 (9.8, —) | 20.9 (5.4, 21.7) | ||
| CL1LOCL3LO | 18 | 6 | 9 | — (8.8, —) | 9.0 (6.8, —) | ||
| CL1LOCL3HI | 14 | 0 | 6 | — — | — (3.2, —) | ||
| CL1HI/CL2LO versus all other groups combined‡ | |||||||
| CL1HICL2LO | 12 | 7 | 10 | 10.6 (8.6, —) | .0102 | 2.8 (0.6, 5.4) | < .0001 |
| all other groups | 52 | 17 | 26 | 21.8 (14.5, —) | 9.4 (7.9, 21.7 | ||
| CL1HI/CL3LO versus all other groups combined§ | |||||||
| CL1HICL3LO | 14 | 11 | 12 | 11.2 (8.6, 15.3) | .007 | 3.8 (1.3, 6.8) | .0009 |
| All other groups | 50 | 13 | 24 | — (16.9, —) | 9.6 (7.9, 21.7) | ||
| Characteristic . | No. Total . | No. Expired . | No. Treated . | OS . | TTFT . | ||
|---|---|---|---|---|---|---|---|
| Median, y (95% CI) . | P* . | Median, y (95% CI) . | P* . | ||||
| All patients | 84 | 31 | 42 | 16.9 (14.4, —)† | 8.05 (6.8, 21.7) | ||
| CL1 | |||||||
| > Median | 32 | 18 | 21 | 12.5 (10, 21.8) | .013 | 7.6 (3.8, 20.9) | .2196 |
| < Median | 32 | 6 | 15 | — (14.5, —) | 9.6 (7.0, —) | ||
| CL2 | |||||||
| > Median | 32 | 12 | 17 | 16.9 (12.5, —) | .518 | 9.6 (6.8, 21.7) | .110 |
| < Median | 32 | 12 | 19 | 14.5 (10.6, —) | 7.9 (2.8, —) | ||
| CL3 | |||||||
| > Median | 32 | 7 | 15 | 21.8 (16.9, —) | .025 | 20.9 (7.6, 21.7) | .0604 |
| < Median | 32 | 17 | 21 | 14.4 (10.6, 16.3) | 7.0 (2.9, 9.4) | ||
| CL1/CL2 combined group | |||||||
| CL1HI CL2LO | 12 | 7 | 10 | 10.6 (8.6, —) | .0209 | 2.8 (0.6, 5.4) | .0002 |
| CL1HICL2HI | 20 | 11 | 11 | 16.3 (9.8,) | 9.4 (6.8, 21.7) | ||
| CL1LOCL2LO | 20 | 5 | 9 | — (14.4, —) | 9.0 (3.9, —) | ||
| CL1LOCL2HI | 12 | 1 | 6 | — (—) | 9.6 (3.2, —) | ||
| CL1/CL3 combined group | |||||||
| CL1HICL3LO | 14 | 11 | 12 | 11.2 (8.6, 15.3) | .0023 | 3.8 (1.3, 6.8) | .0107 |
| CL1HICL3HI | 18 | 7 | 9 | 21.8 (9.8, —) | 20.9 (5.4, 21.7) | ||
| CL1LOCL3LO | 18 | 6 | 9 | — (8.8, —) | 9.0 (6.8, —) | ||
| CL1LOCL3HI | 14 | 0 | 6 | — — | — (3.2, —) | ||
| CL1HI/CL2LO versus all other groups combined‡ | |||||||
| CL1HICL2LO | 12 | 7 | 10 | 10.6 (8.6, —) | .0102 | 2.8 (0.6, 5.4) | < .0001 |
| all other groups | 52 | 17 | 26 | 21.8 (14.5, —) | 9.4 (7.9, 21.7 | ||
| CL1HI/CL3LO versus all other groups combined§ | |||||||
| CL1HICL3LO | 14 | 11 | 12 | 11.2 (8.6, 15.3) | .007 | 3.8 (1.3, 6.8) | .0009 |
| All other groups | 50 | 13 | 24 | — (16.9, —) | 9.6 (7.9, 21.7) | ||
Bold values indicate a significant difference for single cluster comparisons (P < .05) and for pairwise comparisons (P < .01) of CL1/CL2 and CL1/CL3 combined cluster groups.
— indicates not reached.
The phrase “all other groups combined” refers to the combination of the 3 CL1/CL2 cluster groups with better OS (CL1HI/CL2HI, CL1LO/CL2LO, and CL1LO/CL2HI). CL1HI/CL2LO, and “all other groups combined” are the groups used in multivariate analysis.
“All other groups combined” refers to the combination of CL1HI/CL3HI, CL1LO/CL3LO, and CL1LO/CL3HI.