Serum cytokine levels: CLL versus age-matched healthy subjects
| Cytokine* . | CLL (n = 84) . | Healthy (n = 49) . | P† . | ||
|---|---|---|---|---|---|
| Mean . | Median (range) . | Mean . | Median (range) . | ||
| IL-1β | 38.1 | 6.2 (4-395.9) | 7.9 | 6.2 (4-60.1) | .0038 |
| IL-2 | 32.7 | 3.2 (3.2-560.9) | 6.5 | 3.2 (1.6-69.5) | .0385 |
| IL-4 | 1.4 | 0.3 (0.2-16.6) | 0.9 | 0.3 (0.3-11.5) | .4291 |
| IL-5 | 3.4 | 1.1 (0.2-120.4) | 0.5 | 0.2 (0.1-3.1) | < .0001 |
| IL-6 | 17.3 | 6.9 (0.2-373.7) | 6.1 | 4.4 (0.5-65.7) | .0220 |
| IL-8 | 173.9 | 12.2 (0.8-2465) | 10.2 | 4.5 (1.9-191.9) | .0001 |
| IL-10 | 8.2 | 3.6 (0.3-203.7) | 10.6 | 0.3 (0.2-310.3) | < .0001 |
| IL-12 | 270.3 | 146.5 (5.3-2544.9) | 101.5 | 81.5 (6.7-416) | .0009 |
| IL-15 | 13.8 | 6.4 (1-80.7) | 8.8 | 2.4 (1-47.8) | .1490 |
| IL-17 | 6.9 | 1.3 (0.3-137.7) | 0.9 | 0.3 (0.3-11) | < .0001 |
| TNFα | 7.9 | 1.4 (1.4-117.5) | 1.9 | 1.4 (1.4-6.7) | .0108 |
| IFNα | 15.2 | 2.5 (2.5-136.3) | 5.9 | 2.5 (2.5-49.6) | .0130 |
| IFNγ | 2.0 | 0.9 (0.1-30.7) | 0.8 | 0.3 (0.3-7.7) | .0069 |
| GM-CSF | 15.4 | 1.7 (0.2-412.9) | 20.6 | 1.1 (0.5-783.7) | .1073 |
| CCL2 | 741.6 | 641.8 (95.7-3079.1) | 439.3 | 376.6 (180.7-1468.7) | < .0001 |
| CCL3 | 94.3 | 35.5 (1-2227.3) | 14.0 | 1.0 (1-264.5) | < .0001 |
| CCL4 | 298.3 | 170.6 (1.2-3290.3) | 110.0 | 58.6 (2-1926.1) | < .0001 |
| CCL11 | 159.1 | 146.5 (3-560.3) | 143.4 | 139.4 (30.4-339.2) | .5961 |
| CCL17‡ | 305 | 185 (12.6-1619) | 46.9 | 42 (11.8-84.3) | .0001 |
| CCL19§ | 146.9 | 108.1 (20.3-699.2) | 149.0 | 118.4 (9.4-652.4) | .3566 |
| CXCL9§ | 862.5 | 402.1 (59.3-7302.4) | 257.9 | 197.2 (59.9-1082.4) | .0021 |
| CXCL10§ | 131.6 | 83.1 (13.2-518.6) | 102.9 | 75.5 (14.9-740.5) | .2889 |
| CXCL11§ | 166.5 | 107.2 (13.5-1505.9) | 56.0 | 26.5 (8.8-275) | < .0001 |
| Cytokine* . | CLL (n = 84) . | Healthy (n = 49) . | P† . | ||
|---|---|---|---|---|---|
| Mean . | Median (range) . | Mean . | Median (range) . | ||
| IL-1β | 38.1 | 6.2 (4-395.9) | 7.9 | 6.2 (4-60.1) | .0038 |
| IL-2 | 32.7 | 3.2 (3.2-560.9) | 6.5 | 3.2 (1.6-69.5) | .0385 |
| IL-4 | 1.4 | 0.3 (0.2-16.6) | 0.9 | 0.3 (0.3-11.5) | .4291 |
| IL-5 | 3.4 | 1.1 (0.2-120.4) | 0.5 | 0.2 (0.1-3.1) | < .0001 |
| IL-6 | 17.3 | 6.9 (0.2-373.7) | 6.1 | 4.4 (0.5-65.7) | .0220 |
| IL-8 | 173.9 | 12.2 (0.8-2465) | 10.2 | 4.5 (1.9-191.9) | .0001 |
| IL-10 | 8.2 | 3.6 (0.3-203.7) | 10.6 | 0.3 (0.2-310.3) | < .0001 |
| IL-12 | 270.3 | 146.5 (5.3-2544.9) | 101.5 | 81.5 (6.7-416) | .0009 |
| IL-15 | 13.8 | 6.4 (1-80.7) | 8.8 | 2.4 (1-47.8) | .1490 |
| IL-17 | 6.9 | 1.3 (0.3-137.7) | 0.9 | 0.3 (0.3-11) | < .0001 |
| TNFα | 7.9 | 1.4 (1.4-117.5) | 1.9 | 1.4 (1.4-6.7) | .0108 |
| IFNα | 15.2 | 2.5 (2.5-136.3) | 5.9 | 2.5 (2.5-49.6) | .0130 |
| IFNγ | 2.0 | 0.9 (0.1-30.7) | 0.8 | 0.3 (0.3-7.7) | .0069 |
| GM-CSF | 15.4 | 1.7 (0.2-412.9) | 20.6 | 1.1 (0.5-783.7) | .1073 |
| CCL2 | 741.6 | 641.8 (95.7-3079.1) | 439.3 | 376.6 (180.7-1468.7) | < .0001 |
| CCL3 | 94.3 | 35.5 (1-2227.3) | 14.0 | 1.0 (1-264.5) | < .0001 |
| CCL4 | 298.3 | 170.6 (1.2-3290.3) | 110.0 | 58.6 (2-1926.1) | < .0001 |
| CCL11 | 159.1 | 146.5 (3-560.3) | 143.4 | 139.4 (30.4-339.2) | .5961 |
| CCL17‡ | 305 | 185 (12.6-1619) | 46.9 | 42 (11.8-84.3) | .0001 |
| CCL19§ | 146.9 | 108.1 (20.3-699.2) | 149.0 | 118.4 (9.4-652.4) | .3566 |
| CXCL9§ | 862.5 | 402.1 (59.3-7302.4) | 257.9 | 197.2 (59.9-1082.4) | .0021 |
| CXCL10§ | 131.6 | 83.1 (13.2-518.6) | 102.9 | 75.5 (14.9-740.5) | .2889 |
| CXCL11§ | 166.5 | 107.2 (13.5-1505.9) | 56.0 | 26.5 (8.8-275) | < .0001 |
Cytokine values are reported in picograms per milliliter.
Results of Mann-Whitney nonparametric test comparing median values. Bold values indicate significant difference (P < .05) between CLL and age-matched healthy subjects.
For this cytokine, there were only 36 CLL subjects and 10 controls subjects.
For this cytokine, there were only 63 CLL and 42 healthy subjects.