Prognostic factors affecting the OS of patients with DLBCL
| Characteristic . | Age- and sex-adjusted analysis . | Multivariate analysis 1* . | Multivariate analysis 2† . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| PD-L1+ vs PD-L1– | 2.206 (1.334-3.649) | .0021 | 1.809 (1.051-3.112) | .0323 | 1.599 (0.943-2.713) | .0818 |
| Stage III/IV vs I/II | 2.887 (1.791-4.654) | <.0001 | 1.704 (0.986-2.945) | .0561 | ||
| LDH elevated vs normal | 2.488 (1.499-4.129) | .0004 | 1.713 (1.008-2.912) | .0466 | ||
| Extranodal sites ≥2 vs ≤1 | 2.328 (1.549-3.500) | <.0001 | 1.618 (1.030-2.543) | .0368 | ||
| ECOG PS >1 vs ≤1 | 2.556 (1.706-3.830) | <.0001 | 1.976 (1.287-3.034) | .0019 | ||
| B symptoms present vs absent | 1.686 (1.103-2.575) | .0157 | 0.845 (0.526-1.358) | .4874 | 1.058 (0.673-1.664) | .8063 |
| Non-GCB vs GCB type | 1.445 (0.941-2.221) | .0928 | 1.256 (0.805-1.960) | .3159 | 1.287 (0.830-1.996) | .2593 |
| IPI high/high-intermediate vs low/low-intermediate | 3.773 (2.341-6.080)‡ | <.0001 | 3.447 (2.081-5.710) | <.0001 | ||
| Characteristic . | Age- and sex-adjusted analysis . | Multivariate analysis 1* . | Multivariate analysis 2† . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| PD-L1+ vs PD-L1– | 2.206 (1.334-3.649) | .0021 | 1.809 (1.051-3.112) | .0323 | 1.599 (0.943-2.713) | .0818 |
| Stage III/IV vs I/II | 2.887 (1.791-4.654) | <.0001 | 1.704 (0.986-2.945) | .0561 | ||
| LDH elevated vs normal | 2.488 (1.499-4.129) | .0004 | 1.713 (1.008-2.912) | .0466 | ||
| Extranodal sites ≥2 vs ≤1 | 2.328 (1.549-3.500) | <.0001 | 1.618 (1.030-2.543) | .0368 | ||
| ECOG PS >1 vs ≤1 | 2.556 (1.706-3.830) | <.0001 | 1.976 (1.287-3.034) | .0019 | ||
| B symptoms present vs absent | 1.686 (1.103-2.575) | .0157 | 0.845 (0.526-1.358) | .4874 | 1.058 (0.673-1.664) | .8063 |
| Non-GCB vs GCB type | 1.445 (0.941-2.221) | .0928 | 1.256 (0.805-1.960) | .3159 | 1.287 (0.830-1.996) | .2593 |
| IPI high/high-intermediate vs low/low-intermediate | 3.773 (2.341-6.080)‡ | <.0001 | 3.447 (2.081-5.710) | <.0001 | ||
CI, confidence interval; HR, hazard ratio.
The variables included in multivariate analysis 1 for OS were age, sex, stage, LDH, extranodal site, ECOG PS, B symptoms, Hans algorithm, and the expression of PD-L1.
The variables included in the second multivariate analysis for OS were sex, B symptoms, Hans algorithm, IPI, and the expression of PD-L1.
Sex-adjusted analysis.