Changes in evaluation indicators before and after salvage therapy
| . | At HLH diagnosis . | Before DEP regimen . | 2 weeks after DEP regimen . | 4 weeks after DEP regimen . |
|---|---|---|---|---|
| WBC (×109/L) | 1.88 ± 0.89 | 1.60 ± 0.86 | 3.05 ± 1.91 | 4.26 ± 1.49 |
| P value | .119 | 9.711 × 10−6 | 9.339 × 10-17 | |
| Hgb (g/L) | 84.54 ± 18.13 | 79.98 ± 15.87 | 81.63 ± 17.97 | 90.40 ± 17.59 |
| P value | .193 | 0.635 | 0.003 | |
| PLT (×109/L) | 52.88 ± 28.72 | 61.33 ± 55.90 | 88.25 ± 67.11 | 115.79 ± 67.34 |
| P value | .354 | .035 | 4.003 × 10-5 | |
| Ferritin (μg/L) | 3386.0 (622-55 402.0) | 6786.5 (555.0-44 180.0) | 2339.0 (67.4-21 489.0) | 1119.5 (79.2-9372.0) |
| P value | 0.048 | 5.389 × 10-5 | 6.183 × 10-9 | |
| ALT (U/L) | 104.92 ± 80.02 | 95.96 ± 70.58 | 69.60 ± 42.30 | 37.83 ± 24.12 |
| P value | .562 | .029 | 1.311 × 10-6 | |
| TBIL (μmol/L) | 23.48 (8.5-293.0) | 25.45 (5-308.0) | 20.28 (4.6-181.2) | 19.89 (5.54-137.0) |
| P value | .671 | .324 | .151 | |
| TG (mmol/L) | 2.64 ± 1.22 | 2.76 ± 1.34 | 2.25 ± 0.79 | 2.28 ± 0.97 |
| P value | .636 | .027 | .048 | |
| ALB (g/L) | 31.47 ± 6.20 | 30.62 ± 6.96 | 31.73 ± 5.32 | 32.81 ± 5.08 |
| P value | .528 | .386 | .083 | |
| Fbg (g/L) | 1.54 (0.47-5.70) | 1.51 (0.60-5.04) | 1.65 (0.71-6.09) | 1.70 (0.93-3.38) |
| P value | .265 | .070 | .003 | |
| sCD25 (pg/mL) | 22435.0 (8695.0-44 000.0) | 39285.0 (10 485.0-44 000.0) | 16 100.9 (4598.0-29 167.0) | 6878 (2117.0-15 152.0) |
| P value | .004 | 2.794 × 10-11 | 2.030 × 10-16 |
| . | At HLH diagnosis . | Before DEP regimen . | 2 weeks after DEP regimen . | 4 weeks after DEP regimen . |
|---|---|---|---|---|
| WBC (×109/L) | 1.88 ± 0.89 | 1.60 ± 0.86 | 3.05 ± 1.91 | 4.26 ± 1.49 |
| P value | .119 | 9.711 × 10−6 | 9.339 × 10-17 | |
| Hgb (g/L) | 84.54 ± 18.13 | 79.98 ± 15.87 | 81.63 ± 17.97 | 90.40 ± 17.59 |
| P value | .193 | 0.635 | 0.003 | |
| PLT (×109/L) | 52.88 ± 28.72 | 61.33 ± 55.90 | 88.25 ± 67.11 | 115.79 ± 67.34 |
| P value | .354 | .035 | 4.003 × 10-5 | |
| Ferritin (μg/L) | 3386.0 (622-55 402.0) | 6786.5 (555.0-44 180.0) | 2339.0 (67.4-21 489.0) | 1119.5 (79.2-9372.0) |
| P value | 0.048 | 5.389 × 10-5 | 6.183 × 10-9 | |
| ALT (U/L) | 104.92 ± 80.02 | 95.96 ± 70.58 | 69.60 ± 42.30 | 37.83 ± 24.12 |
| P value | .562 | .029 | 1.311 × 10-6 | |
| TBIL (μmol/L) | 23.48 (8.5-293.0) | 25.45 (5-308.0) | 20.28 (4.6-181.2) | 19.89 (5.54-137.0) |
| P value | .671 | .324 | .151 | |
| TG (mmol/L) | 2.64 ± 1.22 | 2.76 ± 1.34 | 2.25 ± 0.79 | 2.28 ± 0.97 |
| P value | .636 | .027 | .048 | |
| ALB (g/L) | 31.47 ± 6.20 | 30.62 ± 6.96 | 31.73 ± 5.32 | 32.81 ± 5.08 |
| P value | .528 | .386 | .083 | |
| Fbg (g/L) | 1.54 (0.47-5.70) | 1.51 (0.60-5.04) | 1.65 (0.71-6.09) | 1.70 (0.93-3.38) |
| P value | .265 | .070 | .003 | |
| sCD25 (pg/mL) | 22435.0 (8695.0-44 000.0) | 39285.0 (10 485.0-44 000.0) | 16 100.9 (4598.0-29 167.0) | 6878 (2117.0-15 152.0) |
| P value | .004 | 2.794 × 10-11 | 2.030 × 10-16 |
ALB, albumin; TBIL, total bilirubin.