Treatment schedule in frail patients with MM
| Frontline treatment . | Second-line treatment . | Following lines of treatment . |
|---|---|---|
| Lenalidomide-steroid R*: 10-15 mg/d, d 1-21 d: 10 mg/d once weekly or P: 25 mg/d every other d | Bortezomib-steroid V: 1.3 mg/m2 once weekly d: 10 mg/d once weekly or P: 25 mg/d every other d | Melphalan-prednisone M: 2 mg every other d P: 25 mg/d every other d |
| Bortezomib-steroid V: 1.3 mg/m2 once weekly d: 10 mg/d once weekly or P: 25 mg/d every other d | Lenalidomide-steroid R*: 10-15 mg/d, d 1-21 d: 10 mg/d once weekly or P: 25 mg/d every other d | Cyclophosphamide-prednisone C: 50 mg every other d P: 25 mg/d every other d |
| Re-treatment | Thalidomide-prednisone T: 50 mg every other d P: 25 mg/d every other d |
| Frontline treatment . | Second-line treatment . | Following lines of treatment . |
|---|---|---|
| Lenalidomide-steroid R*: 10-15 mg/d, d 1-21 d: 10 mg/d once weekly or P: 25 mg/d every other d | Bortezomib-steroid V: 1.3 mg/m2 once weekly d: 10 mg/d once weekly or P: 25 mg/d every other d | Melphalan-prednisone M: 2 mg every other d P: 25 mg/d every other d |
| Bortezomib-steroid V: 1.3 mg/m2 once weekly d: 10 mg/d once weekly or P: 25 mg/d every other d | Lenalidomide-steroid R*: 10-15 mg/d, d 1-21 d: 10 mg/d once weekly or P: 25 mg/d every other d | Cyclophosphamide-prednisone C: 50 mg every other d P: 25 mg/d every other d |
| Re-treatment | Thalidomide-prednisone T: 50 mg every other d P: 25 mg/d every other d |
C, cyclophosphamide; d, dexamethasone; M, melphalan; P, prednisone; R, lenalidomide; T, thalidomide; V, bortezomib.
Or according to renal function.