Laboratory tests according to VHLR200W status
| . | N . | Controls . | N . | VHLR200W homozygotes . | P . |
|---|---|---|---|---|---|
| Hemoglobin, g/dL* | 52 | 12.8 (12.3-13.3) | 90 | 17.3 (16.8-17.8) | < .001† |
| RBCs, ×106/μL | 52 | 4.3 (4.2-4.5) | 90 | 6.5 (6.3-6.7) | < .001† |
| Mean corpuscular volume, fL | 52 | 89 (87-91) | 79 | 80 (78-82) | < .001† |
| Mean corpuscular hemoglobin concentration, g/dL | 52 | 32.9 (32.3-33.5) | 80 | 32.9 (32.4-33.5) | .8 |
| WBCs, ×1000/μL | 52 | 6.5 (6.2-6.9) | 90 | 5.6 (5.3-6.0) | .002† |
| Platelets, ×1000/μL | 52 | 248 (232-265) | 90 | 208 (193-224) | < .001† |
| Ferritin, μg/L* | 50 | 53 (39-73) | 77 | 11 (9-15) | < .001† |
| Iron, μg/dL | 52 | 68 (60-78) | 88 | 36 (29-45) | < .001† |
| Iron-binding capacity, μg/dL | 52 | 354 (339-370) | 77 | 483 (465-503) | < .001† |
| Transferrin saturation, % | 52 | 19 (17-22) | 77 | 10 (8-12) | < .001† |
| Protein, g/dL | 52 | 7.2 (7.0-7.4) | 88 | 7.4 (7.3-7.5) | 0.10 |
| Albumin, g/dL | 52 | 4.4 (4.3-4.5) | 88 | 4.4 (4.3-4.5) | 0.6 |
| Globulin, g/dL | 52 | 2.8 (2.7-2.9) | 88 | 3.0 (2.9-3.0) | 0.008 |
| Albumin/globulin ratio | 52 | 1.6 (1.5-1.7) | 88 | 1.5 (1.4-1.5) | 0.006 |
| Erythropoietin, IU/L | 50 | 9.7 (8.6-11.1) | 77 | 51.5 (42.3-62.8) | < .001† |
| Hepcidin, ng/mL | 52 | 40.8 (29.6-56.3) | 90 | 6.0 (5.0-7.6) | < .001† |
| . | N . | Controls . | N . | VHLR200W homozygotes . | P . |
|---|---|---|---|---|---|
| Hemoglobin, g/dL* | 52 | 12.8 (12.3-13.3) | 90 | 17.3 (16.8-17.8) | < .001† |
| RBCs, ×106/μL | 52 | 4.3 (4.2-4.5) | 90 | 6.5 (6.3-6.7) | < .001† |
| Mean corpuscular volume, fL | 52 | 89 (87-91) | 79 | 80 (78-82) | < .001† |
| Mean corpuscular hemoglobin concentration, g/dL | 52 | 32.9 (32.3-33.5) | 80 | 32.9 (32.4-33.5) | .8 |
| WBCs, ×1000/μL | 52 | 6.5 (6.2-6.9) | 90 | 5.6 (5.3-6.0) | .002† |
| Platelets, ×1000/μL | 52 | 248 (232-265) | 90 | 208 (193-224) | < .001† |
| Ferritin, μg/L* | 50 | 53 (39-73) | 77 | 11 (9-15) | < .001† |
| Iron, μg/dL | 52 | 68 (60-78) | 88 | 36 (29-45) | < .001† |
| Iron-binding capacity, μg/dL | 52 | 354 (339-370) | 77 | 483 (465-503) | < .001† |
| Transferrin saturation, % | 52 | 19 (17-22) | 77 | 10 (8-12) | < .001† |
| Protein, g/dL | 52 | 7.2 (7.0-7.4) | 88 | 7.4 (7.3-7.5) | 0.10 |
| Albumin, g/dL | 52 | 4.4 (4.3-4.5) | 88 | 4.4 (4.3-4.5) | 0.6 |
| Globulin, g/dL | 52 | 2.8 (2.7-2.9) | 88 | 3.0 (2.9-3.0) | 0.008 |
| Albumin/globulin ratio | 52 | 1.6 (1.5-1.7) | 88 | 1.5 (1.4-1.5) | 0.006 |
| Erythropoietin, IU/L | 50 | 9.7 (8.6-11.1) | 77 | 51.5 (42.3-62.8) | < .001† |
| Hepcidin, ng/mL | 52 | 40.8 (29.6-56.3) | 90 | 6.0 (5.0-7.6) | < .001† |