Clinical characteristics of study participants according to VHLR200W status
| . | Controls (n = 52) . | VHLR200W homozygotes (n = 90) . | P . |
|---|---|---|---|
| Age, y | 49 (14) | 43 (13) | .008 |
| Female sex, no (%) | 34 (65%) | 52 (58%) | .4 |
| History of smoking, no (%) | 6 (12%) | 25 (28%) | .024 |
| History of alcohol consumption, no (%) | 9 (17%) | 16 (18%) | .9 |
| History of bleeding in the past year (principally menorrhagia or gastrointestinal), no (%) | 3 (6%) | 8 (9%) | .5 |
| History of thrombosis, no (%) | 5 (10%) | 3 (3%) | .12 |
| Phlebotomy in past year, no (%) | 0 | 46 (51%) | < .001* |
| Body mass index, kg/m2 | 25.5 (5.2) | 23.1 (3.4) | .004* |
| Systolic blood pressure, mmHg | 132 (23) | 122 (19) | .010 |
| Diastolic blood pressure, mmHg | 84 (11) | 81 (10) | .14 |
| Mean blood pressure, mmHg | 100 (14) | 95 (12) | .031 |
| . | Controls (n = 52) . | VHLR200W homozygotes (n = 90) . | P . |
|---|---|---|---|
| Age, y | 49 (14) | 43 (13) | .008 |
| Female sex, no (%) | 34 (65%) | 52 (58%) | .4 |
| History of smoking, no (%) | 6 (12%) | 25 (28%) | .024 |
| History of alcohol consumption, no (%) | 9 (17%) | 16 (18%) | .9 |
| History of bleeding in the past year (principally menorrhagia or gastrointestinal), no (%) | 3 (6%) | 8 (9%) | .5 |
| History of thrombosis, no (%) | 5 (10%) | 3 (3%) | .12 |
| Phlebotomy in past year, no (%) | 0 | 46 (51%) | < .001* |
| Body mass index, kg/m2 | 25.5 (5.2) | 23.1 (3.4) | .004* |
| Systolic blood pressure, mmHg | 132 (23) | 122 (19) | .010 |
| Diastolic blood pressure, mmHg | 84 (11) | 81 (10) | .14 |
| Mean blood pressure, mmHg | 100 (14) | 95 (12) | .031 |
Results are means (SD) unless otherwise indicated.
Significant after the Bonferroni correction for multiple comparisons.