Summaries of TRM reporting in acute lymphoblastic leukemia, acute myeloid leukemia, and acute promyelocytic leukemia trials
| . | Provide definition of TRM . | Describe TRM over entire course of treatment . | Include deaths before starting chemotherapy* . | Include deaths after completing chemotherapy . | Include deaths after stem cell transplantation . | Include accidents, suicide, or unknown . | Use time from start treatment to define TRM . |
|---|---|---|---|---|---|---|---|
| Pediatric acute lymphoblastic leukemia N = 32 | 2 (6.3) | 2 (6.3) | 2 yes; 12 no; 2 exclude; 12 unknown; 4 NA | 6 (18.8) | 6 (18.8) | 6 (18.8) | 1 (3.1) |
| Pediatric acute myeloid leukemia N = 9 | 6 (66.7) | 3 (33.3) | 4 yes; 2 no; 2 unknown; 1 NA | 1 (11.1) | 5 (55.6) | 2 (22.2) | 4 (44.4) |
| Studies of TRM in pediatric acute leukemia N = 10 | 7 (70.0) | 8 (80.0) | 4 yes; 2 no; 4 unknown | 3 (30.0) | 7 (70.0) | 5 (50.0) | 3 (30.0) |
| Adult and pediatric acute promyelocytic leukemia N = 15 | 8 (53.3) | 0 (0) | 1 yes; 3 no; 5 exclude; 6 unknown | 1 (6.7) | 0 (0) | 4 (26.7) | 4 (26.7) |
| . | Provide definition of TRM . | Describe TRM over entire course of treatment . | Include deaths before starting chemotherapy* . | Include deaths after completing chemotherapy . | Include deaths after stem cell transplantation . | Include accidents, suicide, or unknown . | Use time from start treatment to define TRM . |
|---|---|---|---|---|---|---|---|
| Pediatric acute lymphoblastic leukemia N = 32 | 2 (6.3) | 2 (6.3) | 2 yes; 12 no; 2 exclude; 12 unknown; 4 NA | 6 (18.8) | 6 (18.8) | 6 (18.8) | 1 (3.1) |
| Pediatric acute myeloid leukemia N = 9 | 6 (66.7) | 3 (33.3) | 4 yes; 2 no; 2 unknown; 1 NA | 1 (11.1) | 5 (55.6) | 2 (22.2) | 4 (44.4) |
| Studies of TRM in pediatric acute leukemia N = 10 | 7 (70.0) | 8 (80.0) | 4 yes; 2 no; 4 unknown | 3 (30.0) | 7 (70.0) | 5 (50.0) | 3 (30.0) |
| Adult and pediatric acute promyelocytic leukemia N = 15 | 8 (53.3) | 0 (0) | 1 yes; 3 no; 5 exclude; 6 unknown | 1 (6.7) | 0 (0) | 4 (26.7) | 4 (26.7) |
Values are n (%).
NA indicates not applicable; and TRM, treatment-related mortality.
Yes indicates that the study classified deaths before starting chemotherapy as early death or TRM; no, no deaths before starting treatment; exclude, specifically excluded deaths before starting treatment in the outcome analysis; unknown, we could not ascertain how deaths before starting treatment were handled; and NA, study did not include patients in induction.