Known palmitoylated proteins of the platelet palmitoylome
| Protein name . | Gene name . | Ratio . | P . | Source . |
|---|---|---|---|---|
| Cell growth and/or maintenance | ||||
| Claudin-3 | CLDN3 | 16.50 | .000009 | Proteomic studies18 |
| Desmoplakin | DSP | 2.90 | .048440 | Proteomic studies17 |
| Flotillin-1 | FLOT1 | 14.80 | .000018 | Manual |
| 55-kDa erythrocyte membrane protein | MPP1 | 3.00 | .043487 | Uniprot |
| Immune response | ||||
| Complement component 1 Q subcomponent-binding protein | C1QBP | 3.00 | .043487 | Proteomic studies17 |
| HLA class I histocompatibility antigen, B-27 α-chain | HLA-B | 9.00 | .000366 | Manual |
| Interferon-induced transmembrane protein 3 | IFITM3 | 3.00 | .043487 | Uniprot |
| Linker for activation of T-cell family member 1 | LAT | 7.33 | .001082 | Uniprot |
| Protein folding | ||||
| Calnexin | CANX | 2.88 | .049774 | Proteomic studies18 |
| Metabolism | ||||
| 3-mercaptopyruvate sulfur transferase | MPST | 3.33 | .030650 | Proteomic studies17 |
| 4-aminobutyrate aminotransferase | ABAT | 4.00 | .015866 | Proteomic studies17 |
| ADP-ribosyl cyclase 1 | CD38 | 5.00 | .006457 | Proteomic studies17 |
| Acid ceramidase | ASAH1 | 5.25 | .005232 | Proteomic studies18 |
| ATP synthase subunit γ | ATP5L | 4.00 | .015866 | Proteomic studies17 |
| CTD small phosphatase-like protein | CTDSPL | 8.25 | .000586 | Proteomic studies18 |
| Cytochrome b-c1 complex subunit Rieske | UQCRFS1 | 3.00 | .043487 | Proteomic studies17 |
| Glutaminase kidney isoform | GLS | 3.00 | .043487 | Proteomic studies17 |
| NAD(P) transhydrogenase | NNT | 7.92 | .000726 | Proteomic studies17 |
| Probable phospholipid-transporting ATPase IF | ATP11B | 11.00 | .000116 | Proteomic studies18 |
| Sn1-specific diacylglycerol lipase-β | DAGLB | 29.00 | 1.29E-07 | Proteomic studies18 |
| Protein metabolism | ||||
| Cation-dependent mannose-6-phosphate receptor | M6PR | 7.00 | .001366 | Manual |
| DnaJ homolog subfamily C member 5 | DNAJC5 | 27.00 | 2.29E-07 | Uniprot |
| Endothelin-converting enzyme 1 | ECE1 | 35.00 | 2.72E-08 | Manual |
| F-box/LRR-repeat protein 20 | FBXL20 | 6.00 | .002867 | Proteomic studies18 |
| Signal transduction | ||||
| Adenylate cyclase type 6 | ADCY6 | 3.40 | .028628 | Proteomic studies17 |
| ADP-ribosylation factor 5 | ARF5 | 3.00 | .043487 | Proteomic studies17 |
| ADP-ribosylation factor-like protein 15 | ARL15 | 5.25 | .005232 | Proteomic studies18 |
| Casein kinase I γ1 isoform | CSNK1G1 | 3.00 | .043487 | Proteomic studies17 |
| Casein kinase I isoform γ3 | CSNK1G3 | 8.00 | .000690 | Proteomic studies17 |
| CD151 antigen | CD151 | 3.00 | .043487 | Uniprot |
| CD63 antigen | CD63 | 3.67 | .021908 | Manual |
| CD82 antigen | CD82 | 4.00 | .015866 | Manual |
| CDC42 small effector protein 1 | CDC42SE1 | 3.00 | .043487 | Uniprot |
| CDC42 small effector protein 2 | CDC42SE2 | 9.00 | .000366 | Uniprot |
| Cell division control protein 42 homolog | CDC42 | 3.00 | .043487 | Manual |
| Choline transporter-like protein 2 | CTL2 | 27.00 | 2.29E-07 | Proteomic studies18 |
| Disks large-associated protein 4 | DLGAP4 | 6.00 | .002867 | Proteomic studies17 |
| Disheveled-associated activator of morphogenesis 1 | DAAM1 | 9.00 | .000366 | Proteomic studies17 |
| Dystroglycan | DAG1 | 4.00 | .015866 | Proteomic studies17 |
| Erbb2-interacting protein | ERBB2IP | 8.88 | .000395 | Manual |
| Flotillin-2 | FLOT2 | 10.55 | .000149 | Manual |
| G protein-coupled receptor kinase 6 | GRK6 | 8.00 | .000690 | Probable |
| G(i) α-1 | GNAI1 | 3.80 | .019226 | HPRD |
| G(i) α-2 | GNAI2 | 3.25 | .033301 | Manual |
| G(i) α-3 | GNAI3 | 4.86 | .007300 | HPRD |
| G(q) α | GNAQ | 5.17 | .005609 | HPRD |
| G(s) α | GNAS | 5.80 | .003352 | Manual |
| Gα-11 | GNA11 | 6.00 | .002867 | HPRD |
| Gα-13 | GNA13 | 7.45 | .000998 | Uniprot |
| Gα-15 | GNA15 | 4.00 | .015866 | Manual |
| GTPase Hras | HRAS | 7.00 | .001366 | Uniprot |
| GTPase Nras | NRAS | 5.25 | .005232 | Uniprot |
| Junctional adhesion molecule C | JAM3 | 5.14 | .005722 | Proteomic studies17 |
| Kalirin | KALRN | 7.50 | .000965 | Proteomic studies17 |
| Linker for activation of T-cell family member 2 | LAT2 | 7.00 | .001366 | Probable |
| Mitochondrial import inner membrane translocase subunit TIM50 | TIMM50 | 4.00 | .015866 | Proteomic studies24 |
| Phosphatidylinositol 4-kinase type 2-α | PI4K2A | 10.00 | .000202 | Manual |
| Phosphatidylinositol 4-kinase type 2-β | PI4K2B | 3.00 | .043487 | Manual |
| Phospholipid scramblase 1 | PLSCR1 | 20.50 | .000002 | Potential |
| Platelet glycoprotein 4 | CD36 | 6.14 | .002569 | Uniprot |
| Prostacyclin receptor | PTGIR | 10.00 | .000202 | Uniprot |
| Proto-oncogene tyrosine-protein kinase Fyn | FYN | 4.91 | .006980 | HPRD |
| Proto-oncogene tyrosine-protein kinase Yes | YES1 | 10.00 | .000202 | Proteomic studies18 |
| Raftlin | RFTN1 | 5.00 | .006457 | Probable |
| Ras-related protein Rap-2a | RAP2A | 28.00 | .000000 | by similarity |
| Ras-related protein Rap-2b | RAP2B | 3.93 | .017042 | by similarity |
| Ras-related protein Rap-2c | RAP2C | 11.50 | .000089 | by similarity |
| Ras-related protein R-Ras | RRAS | 7.44 | .001002 | Manual |
| Regulator of G-protein signaling 19 | RGS19 | 15.00 | .000016 | Uniprot |
| Semaphorin-4D | SEMA4D | 6.00 | .002867 | Proteomic studies17 |
| Sortilin | SORT1 | 3.00 | .043487 | Proteomic studies17 |
| Stomatin | STOM | 3.29 | .031966 | Uniprot |
| Tetraspanin-9 | TSPAN9 | 6.67 | .001737 | Proteomic studies18 |
| Thromboxane A2 receptor | TBXA2R | 4.00 | .015866 | Manual |
| Transmembrane protein 55B | TMEM55B | 3.50 | .025869 | Proteomic studies17 |
| Type I inositol-1,4,5-trisphosphate 5-phosphatase | INPP5A | 10.67 | .000139 | Potential |
| Tyrosine-protein kinase Lyn | LYN | 5.00 | .006457 | by similarity |
| Transcription regulator activity | ||||
| Histone H2B type 1-N | HIST1H2BN | 6.00 | .002867 | Proteomic studies17 |
| Transport | ||||
| AFG3-like protein 2 | AFG3L2 | 4.00 | .015866 | Proteomic studies17 |
| ATP-binding cassette subfamily B member 6 | ABCB6 | 5.00 | .006457 | Proteomic studies18 |
| Choline transporter-like protein 1 | CTL1 | 14.20 | .000024 | Proteomic studies18 |
| Cytochrome b5 type B | CYB5B | 3.67 | .021908 | Proteomic studies17 |
| Golgin subfamily A member 7 | GOLGA7 | 17.00 | .000007 | Uniprot |
| Multidrug resistance-associated protein 4 | ABCC4 | 3.00 | .043487 | Proteomic studies18 |
| Phospholipid scramblase 3 | PLSCR3 | 13.00 | .000042 | Probable |
| Phospholipid scramblase 4 | PLSCR4 | 7.00 | .001366 | Probable |
| Pituitary tumor-transforming gene 1 protein-interacting protein | PTTG1IP | 19.50 | .000003 | Proteomic studies18 |
| PRA1 family protein 2 | PRAF2 | 14.00 | .000026 | Proteomic studies17 |
| Protein tweety homolog 3 | TTYH3 | 11.00 | .000116 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 1 | SCAMP1 | 10.25 | .000175 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 2 | SCAMP2 | 3.95 | .016681 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 3 | SCAMP3 | 16.00 | .000011 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 4 | SCAMP4 | 3.00 | .043487 | Proteomic studies17 |
| Sodium/potassium-transporting ATPase subunit α-1 | ATP1A1 | 3.00 | .043487 | Proteomic studies17 |
| SNAP-23 | SNAP23 | 3.74 | .020385 | HPRD |
| Syntaxin-8 | STX8 | 11.00 | .000116 | Manual |
| Syntaxin-12 | STX12 | 4.00 | .015866 | Proteomic studies17 |
| Trafficking protein particle complex subunit 3 | TRAPPC3 | 8.67 | .000450 | by similarity |
| Transferrin receptor protein 1 | TFRC | 3.00 | .043487 | Uniprot |
| Vesicle-associated membrane protein 3 | VAMP3 | 8.43 | .000523 | Proteomic studies18 |
| Vesicle-associated membrane protein 4 | VAMP4 | 10.00 | .000202 | Proteomic studies17 |
| Vesicle-associated membrane protein 7 | VAMP7 | 3.69 | .021361 | Proteomic studies18 |
| Unknown | ||||
| 3-oxoacyl-[acyl-carrier-protein] synthase | OXSM | 6.00 | .002867 | Proteomic studies17 |
| Abhydrolase domain-containing protein FAM108B1 | FAM108B1 | 8.33 | .000556 | Proteomic studies18 |
| Coiled-coil domain-containing protein 109A | CCDC109A | 4.50 | .010000 | Proteomic studies17 |
| Endoplasmic reticulum-Golgi intermediate compartment protein 3 | ERGIC3 | 3.00 | .043487 | Proteomic studies17 |
| Abhydrolase domain-containing protein FAM108A1 | FAM108A1 | 7.50 | .000965 | Proteomic studies23 |
| Protein FAM49B | FAM49B | 21.00 | .000002 | Proteomic studies18 |
| Protein LYRIC gene-1 protein | LYRIC | 18.00 | .000005 | Proteomic studies17 |
| Transmembrane protein 63A | TMEM63A | 7.29 | .001118 | Proteomic studies18 |
| Transmembrane protein 63B | TMEM63B | 3.00 | .043487 | Proteomic studies18 |
| UPF0404 protein C11orf59 | C11orf59 | 5.71 | .003588 | Proteomic studies18 |
| Protein name . | Gene name . | Ratio . | P . | Source . |
|---|---|---|---|---|
| Cell growth and/or maintenance | ||||
| Claudin-3 | CLDN3 | 16.50 | .000009 | Proteomic studies18 |
| Desmoplakin | DSP | 2.90 | .048440 | Proteomic studies17 |
| Flotillin-1 | FLOT1 | 14.80 | .000018 | Manual |
| 55-kDa erythrocyte membrane protein | MPP1 | 3.00 | .043487 | Uniprot |
| Immune response | ||||
| Complement component 1 Q subcomponent-binding protein | C1QBP | 3.00 | .043487 | Proteomic studies17 |
| HLA class I histocompatibility antigen, B-27 α-chain | HLA-B | 9.00 | .000366 | Manual |
| Interferon-induced transmembrane protein 3 | IFITM3 | 3.00 | .043487 | Uniprot |
| Linker for activation of T-cell family member 1 | LAT | 7.33 | .001082 | Uniprot |
| Protein folding | ||||
| Calnexin | CANX | 2.88 | .049774 | Proteomic studies18 |
| Metabolism | ||||
| 3-mercaptopyruvate sulfur transferase | MPST | 3.33 | .030650 | Proteomic studies17 |
| 4-aminobutyrate aminotransferase | ABAT | 4.00 | .015866 | Proteomic studies17 |
| ADP-ribosyl cyclase 1 | CD38 | 5.00 | .006457 | Proteomic studies17 |
| Acid ceramidase | ASAH1 | 5.25 | .005232 | Proteomic studies18 |
| ATP synthase subunit γ | ATP5L | 4.00 | .015866 | Proteomic studies17 |
| CTD small phosphatase-like protein | CTDSPL | 8.25 | .000586 | Proteomic studies18 |
| Cytochrome b-c1 complex subunit Rieske | UQCRFS1 | 3.00 | .043487 | Proteomic studies17 |
| Glutaminase kidney isoform | GLS | 3.00 | .043487 | Proteomic studies17 |
| NAD(P) transhydrogenase | NNT | 7.92 | .000726 | Proteomic studies17 |
| Probable phospholipid-transporting ATPase IF | ATP11B | 11.00 | .000116 | Proteomic studies18 |
| Sn1-specific diacylglycerol lipase-β | DAGLB | 29.00 | 1.29E-07 | Proteomic studies18 |
| Protein metabolism | ||||
| Cation-dependent mannose-6-phosphate receptor | M6PR | 7.00 | .001366 | Manual |
| DnaJ homolog subfamily C member 5 | DNAJC5 | 27.00 | 2.29E-07 | Uniprot |
| Endothelin-converting enzyme 1 | ECE1 | 35.00 | 2.72E-08 | Manual |
| F-box/LRR-repeat protein 20 | FBXL20 | 6.00 | .002867 | Proteomic studies18 |
| Signal transduction | ||||
| Adenylate cyclase type 6 | ADCY6 | 3.40 | .028628 | Proteomic studies17 |
| ADP-ribosylation factor 5 | ARF5 | 3.00 | .043487 | Proteomic studies17 |
| ADP-ribosylation factor-like protein 15 | ARL15 | 5.25 | .005232 | Proteomic studies18 |
| Casein kinase I γ1 isoform | CSNK1G1 | 3.00 | .043487 | Proteomic studies17 |
| Casein kinase I isoform γ3 | CSNK1G3 | 8.00 | .000690 | Proteomic studies17 |
| CD151 antigen | CD151 | 3.00 | .043487 | Uniprot |
| CD63 antigen | CD63 | 3.67 | .021908 | Manual |
| CD82 antigen | CD82 | 4.00 | .015866 | Manual |
| CDC42 small effector protein 1 | CDC42SE1 | 3.00 | .043487 | Uniprot |
| CDC42 small effector protein 2 | CDC42SE2 | 9.00 | .000366 | Uniprot |
| Cell division control protein 42 homolog | CDC42 | 3.00 | .043487 | Manual |
| Choline transporter-like protein 2 | CTL2 | 27.00 | 2.29E-07 | Proteomic studies18 |
| Disks large-associated protein 4 | DLGAP4 | 6.00 | .002867 | Proteomic studies17 |
| Disheveled-associated activator of morphogenesis 1 | DAAM1 | 9.00 | .000366 | Proteomic studies17 |
| Dystroglycan | DAG1 | 4.00 | .015866 | Proteomic studies17 |
| Erbb2-interacting protein | ERBB2IP | 8.88 | .000395 | Manual |
| Flotillin-2 | FLOT2 | 10.55 | .000149 | Manual |
| G protein-coupled receptor kinase 6 | GRK6 | 8.00 | .000690 | Probable |
| G(i) α-1 | GNAI1 | 3.80 | .019226 | HPRD |
| G(i) α-2 | GNAI2 | 3.25 | .033301 | Manual |
| G(i) α-3 | GNAI3 | 4.86 | .007300 | HPRD |
| G(q) α | GNAQ | 5.17 | .005609 | HPRD |
| G(s) α | GNAS | 5.80 | .003352 | Manual |
| Gα-11 | GNA11 | 6.00 | .002867 | HPRD |
| Gα-13 | GNA13 | 7.45 | .000998 | Uniprot |
| Gα-15 | GNA15 | 4.00 | .015866 | Manual |
| GTPase Hras | HRAS | 7.00 | .001366 | Uniprot |
| GTPase Nras | NRAS | 5.25 | .005232 | Uniprot |
| Junctional adhesion molecule C | JAM3 | 5.14 | .005722 | Proteomic studies17 |
| Kalirin | KALRN | 7.50 | .000965 | Proteomic studies17 |
| Linker for activation of T-cell family member 2 | LAT2 | 7.00 | .001366 | Probable |
| Mitochondrial import inner membrane translocase subunit TIM50 | TIMM50 | 4.00 | .015866 | Proteomic studies24 |
| Phosphatidylinositol 4-kinase type 2-α | PI4K2A | 10.00 | .000202 | Manual |
| Phosphatidylinositol 4-kinase type 2-β | PI4K2B | 3.00 | .043487 | Manual |
| Phospholipid scramblase 1 | PLSCR1 | 20.50 | .000002 | Potential |
| Platelet glycoprotein 4 | CD36 | 6.14 | .002569 | Uniprot |
| Prostacyclin receptor | PTGIR | 10.00 | .000202 | Uniprot |
| Proto-oncogene tyrosine-protein kinase Fyn | FYN | 4.91 | .006980 | HPRD |
| Proto-oncogene tyrosine-protein kinase Yes | YES1 | 10.00 | .000202 | Proteomic studies18 |
| Raftlin | RFTN1 | 5.00 | .006457 | Probable |
| Ras-related protein Rap-2a | RAP2A | 28.00 | .000000 | by similarity |
| Ras-related protein Rap-2b | RAP2B | 3.93 | .017042 | by similarity |
| Ras-related protein Rap-2c | RAP2C | 11.50 | .000089 | by similarity |
| Ras-related protein R-Ras | RRAS | 7.44 | .001002 | Manual |
| Regulator of G-protein signaling 19 | RGS19 | 15.00 | .000016 | Uniprot |
| Semaphorin-4D | SEMA4D | 6.00 | .002867 | Proteomic studies17 |
| Sortilin | SORT1 | 3.00 | .043487 | Proteomic studies17 |
| Stomatin | STOM | 3.29 | .031966 | Uniprot |
| Tetraspanin-9 | TSPAN9 | 6.67 | .001737 | Proteomic studies18 |
| Thromboxane A2 receptor | TBXA2R | 4.00 | .015866 | Manual |
| Transmembrane protein 55B | TMEM55B | 3.50 | .025869 | Proteomic studies17 |
| Type I inositol-1,4,5-trisphosphate 5-phosphatase | INPP5A | 10.67 | .000139 | Potential |
| Tyrosine-protein kinase Lyn | LYN | 5.00 | .006457 | by similarity |
| Transcription regulator activity | ||||
| Histone H2B type 1-N | HIST1H2BN | 6.00 | .002867 | Proteomic studies17 |
| Transport | ||||
| AFG3-like protein 2 | AFG3L2 | 4.00 | .015866 | Proteomic studies17 |
| ATP-binding cassette subfamily B member 6 | ABCB6 | 5.00 | .006457 | Proteomic studies18 |
| Choline transporter-like protein 1 | CTL1 | 14.20 | .000024 | Proteomic studies18 |
| Cytochrome b5 type B | CYB5B | 3.67 | .021908 | Proteomic studies17 |
| Golgin subfamily A member 7 | GOLGA7 | 17.00 | .000007 | Uniprot |
| Multidrug resistance-associated protein 4 | ABCC4 | 3.00 | .043487 | Proteomic studies18 |
| Phospholipid scramblase 3 | PLSCR3 | 13.00 | .000042 | Probable |
| Phospholipid scramblase 4 | PLSCR4 | 7.00 | .001366 | Probable |
| Pituitary tumor-transforming gene 1 protein-interacting protein | PTTG1IP | 19.50 | .000003 | Proteomic studies18 |
| PRA1 family protein 2 | PRAF2 | 14.00 | .000026 | Proteomic studies17 |
| Protein tweety homolog 3 | TTYH3 | 11.00 | .000116 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 1 | SCAMP1 | 10.25 | .000175 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 2 | SCAMP2 | 3.95 | .016681 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 3 | SCAMP3 | 16.00 | .000011 | Proteomic studies17 |
| Secretory carrier-associated membrane protein 4 | SCAMP4 | 3.00 | .043487 | Proteomic studies17 |
| Sodium/potassium-transporting ATPase subunit α-1 | ATP1A1 | 3.00 | .043487 | Proteomic studies17 |
| SNAP-23 | SNAP23 | 3.74 | .020385 | HPRD |
| Syntaxin-8 | STX8 | 11.00 | .000116 | Manual |
| Syntaxin-12 | STX12 | 4.00 | .015866 | Proteomic studies17 |
| Trafficking protein particle complex subunit 3 | TRAPPC3 | 8.67 | .000450 | by similarity |
| Transferrin receptor protein 1 | TFRC | 3.00 | .043487 | Uniprot |
| Vesicle-associated membrane protein 3 | VAMP3 | 8.43 | .000523 | Proteomic studies18 |
| Vesicle-associated membrane protein 4 | VAMP4 | 10.00 | .000202 | Proteomic studies17 |
| Vesicle-associated membrane protein 7 | VAMP7 | 3.69 | .021361 | Proteomic studies18 |
| Unknown | ||||
| 3-oxoacyl-[acyl-carrier-protein] synthase | OXSM | 6.00 | .002867 | Proteomic studies17 |
| Abhydrolase domain-containing protein FAM108B1 | FAM108B1 | 8.33 | .000556 | Proteomic studies18 |
| Coiled-coil domain-containing protein 109A | CCDC109A | 4.50 | .010000 | Proteomic studies17 |
| Endoplasmic reticulum-Golgi intermediate compartment protein 3 | ERGIC3 | 3.00 | .043487 | Proteomic studies17 |
| Abhydrolase domain-containing protein FAM108A1 | FAM108A1 | 7.50 | .000965 | Proteomic studies23 |
| Protein FAM49B | FAM49B | 21.00 | .000002 | Proteomic studies18 |
| Protein LYRIC gene-1 protein | LYRIC | 18.00 | .000005 | Proteomic studies17 |
| Transmembrane protein 63A | TMEM63A | 7.29 | .001118 | Proteomic studies18 |
| Transmembrane protein 63B | TMEM63B | 3.00 | .043487 | Proteomic studies18 |
| UPF0404 protein C11orf59 | C11orf59 | 5.71 | .003588 | Proteomic studies18 |
Known palmitoylated proteins as catalogued by the Uniprot or HPRD databases or by review of published palmitoylation-related research articles (manual). Also included in this list are proteins characterized as being palmitoylated by similarity, probably palmitoylated, or potentially palmitoylated as defined by the Uniprot database. A total of 61 of the identified proteins were discovered as palmitoyl protein candidates in other proteomic studies.17,18,24 Data are the result of 2 independent experiments, and proteins are grouped according to the biologic process they mediate as defined by the HPRD. Also shown is the HA+/HA− ratio and corresponding P value.