An OR > 1.0 (< 1.0) means a higher (lower) CR rate for the higher values of the continuous variables and the first category listed for the categorical variables. An HR > 1.0 (< 1.0) corresponds to a higher (lower) risk of an event for higher values of continuous variables and the first category listed of a dichotomous variable. Variables were considered for inclusion in the multivariable models if they had a univariable P < .2. See the supplemental Appendix for a full list of variables evaluated in univariable analyses. Since NPM1, FLT3-ITD, and CEBPA mutations are integrated in the ELN genetic classification, they were not additionally considered as individual variables. Variables that were significant at P < .2 in the univariable models and considered for model inclusion were as follows: In the model for achievement of CR: ASXL1 mutations, ELN genetic group, and their interaction term; WBC, platelet count, age, and extramedullary involvement. In the model for DFS: ASXL1 mutations, ELN group, and their interaction term; WBC, age, and extramedullary involvement. In the model for OS: ASXL1 mutations, ELN group, and their interaction term; WBC, platelet count, and extramedullary involvement. In the model for EFS: ASXL1 mutations, ELN group, and their interaction term; WBC, platelet count, and extramedullary involvement.

The ELN Favorable group is defined as patients with mutated CEBPA and/or mutated NPM1 without FLT3-ITD. All remaining CN-AML patients (ie, those with wild-type CEBPA, and FLT3-ITD and/or wild-type NPM1) belong to the ELN Intermediate-I category.²⁷