Table 4 Prognostic factors and test for... | American Society of Hematology

Table 4

Prognostic factors and test for interaction with treatment arm

	No. of patients	No. of events	5-y RFS %			Cox regression, RFS B vs A			No. dead	5-y OS, %			Cox regression, OS B vs A
	No. of patients	No. of events	All	A	B	HR	95% CI	P	No. dead	All	A	B	HR	95% CI	P
Total	517	359	33	29	38				317	42	41	44
Age, y			P = .010					P_int = .22		P < .001					P_int = .34
≤ 40	177	114	37	29	47	0.65	0.44-0.95	.025	89	52	47	57	0.85	0.56-1.30	.46
41-50	117	72	38	30	46	0.73	0.46-1.16	.18	68	43	39	48	0.82	0.51-1.33	.43
> 50	223	173	28	29	27	0.98	0.73-1.32	.90	160	35	35	34	1.17	0.86-1.60	.33
Extramedullary disease			P = .016					P_int = .25		P = .21					P_int = .85
No	449	304	35	31	39	0.87	0.69-1.08	.21	272	43	41	45	1.03	0.81-1.31	.79
Yes	68	55	22	16	28	0.61	0.36-1.05	.076	45	37	35	38	0.98	0.54-1.76	.93
Cytogenetics			P < .001					P_int = .13		P < .001					P_int = .20
Favorable	39	20	49	33	67	0.39	0.15-1.02	.055	11	72	71	72	1.03	0.31-3.36	.97
Intermediate	393	271	35	32	38	0.87	0.69-1.11	.27	244	43	40	45	1.00	0.78-1.28	.99
Unfavorable	25	20	20	18	21	0.77	0.32-1.86	.56	18	28	27	29	0.99	0.39-2.52	.99
Very unfavorable	28	28	0	0	0	1.76	0.82-3.78	.15	27	4	6	0	2.49	1.15-5.41	.021
CR reached			P < .001					P_int = .35		P < .001					P_int = .29
Cycle 1	413	275	37	32	42	0.78	0.61-0.99	.037	241	45	43	48	0.95	0.74-1.23	.72
Cycle 2	104	84	20	18	21	0.97	0.63-1.49	.89	76	31	31	32	1.25	0.79-1.96	.34

	No. of patients	No. of events	5-y RFS %			Cox regression, RFS B vs A			No. dead	5-y OS, %			Cox regression, OS B vs A
	No. of patients	No. of events	All	A	B	HR	95% CI	P	No. dead	All	A	B	HR	95% CI	P
Total	517	359	33	29	38				317	42	41	44
Age, y			P = .010					P_int = .22		P < .001					P_int = .34
≤ 40	177	114	37	29	47	0.65	0.44-0.95	.025	89	52	47	57	0.85	0.56-1.30	.46
41-50	117	72	38	30	46	0.73	0.46-1.16	.18	68	43	39	48	0.82	0.51-1.33	.43
> 50	223	173	28	29	27	0.98	0.73-1.32	.90	160	35	35	34	1.17	0.86-1.60	.33
Extramedullary disease			P = .016					P_int = .25		P = .21					P_int = .85
No	449	304	35	31	39	0.87	0.69-1.08	.21	272	43	41	45	1.03	0.81-1.31	.79
Yes	68	55	22	16	28	0.61	0.36-1.05	.076	45	37	35	38	0.98	0.54-1.76	.93
Cytogenetics			P < .001					P_int = .13		P < .001					P_int = .20
Favorable	39	20	49	33	67	0.39	0.15-1.02	.055	11	72	71	72	1.03	0.31-3.36	.97
Intermediate	393	271	35	32	38	0.87	0.69-1.11	.27	244	43	40	45	1.00	0.78-1.28	.99
Unfavorable	25	20	20	18	21	0.77	0.32-1.86	.56	18	28	27	29	0.99	0.39-2.52	.99
Very unfavorable	28	28	0	0	0	1.76	0.82-3.78	.15	27	4	6	0	2.49	1.15-5.41	.021
CR reached			P < .001					P_int = .35		P < .001					P_int = .29
Cycle 1	413	275	37	32	42	0.78	0.61-0.99	.037	241	45	43	48	0.95	0.74-1.23	.72
Cycle 2	104	84	20	18	21	0.97	0.63-1.49	.89	76	31	31	32	1.25	0.79-1.96	.34

P values (Cox regression) represent likelihood ratio test for difference between treatment groups within row subgroup. The P values in the “All” columns are for tests for trend or difference between the factor and RFS or OS.

A indicates chemotherapy group; B, ASCT group; HR, hazard ratio estimate; and P_int, P value for the test of interaction between the factor and treatment group.

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