Frequency of adverse events seen at the Phase 2 dose of 50 mg/m2, considered at least possibly related to treatment and seen in ≥2 patients
| Toxicity . | Grade . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | All . | ||||||
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Thrombocytopenia | 4 | 26.7 | 4 | 26.7 | 1 | 6.7 | 9 | 60.0 | ||
| Leukopenia | 2 | 13.3 | 1 | 6.7 | 1 | 6.7 | 4 | 26.7 | ||
| Neutropenia | 1 | 6.7 | 1 | 6.7 | 1 | 6.7 | 1 | 6.7 | 4 | 26.7 |
| Lymphopenia | 4 | 26.7 | 4 | 26.7 | ||||||
| Diarrhea | 9 | 60.0 | 2 | 13.3 | 1 | 6.7 | 1 | 6.7 | 13 | 86.7 |
| Nausea | 6 | 40.0 | 2 | 13.3 | 8 | 53.3 | ||||
| Vomiting | 4 | 26.7 | 1 | 6.7 | 5 | 33.3 | ||||
| Fatigue | 5 | 33.3 | 4 | 26.7 | 1 | 6.7 | 10 | 66.7 | ||
| Aspartate aminotransferase increased | 3 | 20.0 | 3 | 20.0 | ||||||
| Alanine aminotransferase increased | 2 | 13.3 | 2 | 13.3 | ||||||
| Peripheral sensory neuropathy | 2 | 13.3 | 2 | 13.3 | ||||||
| Vision blurred | 1 | 6.7 | 1 | 6.7 | 2 | 13.3 | ||||
| Hypotension | 2 | 13.3 | 2 | 13.3 | ||||||
| Pruritus | 2 | 13.3 | 2 | 13.3 | ||||||
| Dry eye syndrome | 1 | 6.7 | 1 | 6.7 | ||||||
| Toxicity . | Grade . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | All . | ||||||
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Thrombocytopenia | 4 | 26.7 | 4 | 26.7 | 1 | 6.7 | 9 | 60.0 | ||
| Leukopenia | 2 | 13.3 | 1 | 6.7 | 1 | 6.7 | 4 | 26.7 | ||
| Neutropenia | 1 | 6.7 | 1 | 6.7 | 1 | 6.7 | 1 | 6.7 | 4 | 26.7 |
| Lymphopenia | 4 | 26.7 | 4 | 26.7 | ||||||
| Diarrhea | 9 | 60.0 | 2 | 13.3 | 1 | 6.7 | 1 | 6.7 | 13 | 86.7 |
| Nausea | 6 | 40.0 | 2 | 13.3 | 8 | 53.3 | ||||
| Vomiting | 4 | 26.7 | 1 | 6.7 | 5 | 33.3 | ||||
| Fatigue | 5 | 33.3 | 4 | 26.7 | 1 | 6.7 | 10 | 66.7 | ||
| Aspartate aminotransferase increased | 3 | 20.0 | 3 | 20.0 | ||||||
| Alanine aminotransferase increased | 2 | 13.3 | 2 | 13.3 | ||||||
| Peripheral sensory neuropathy | 2 | 13.3 | 2 | 13.3 | ||||||
| Vision blurred | 1 | 6.7 | 1 | 6.7 | 2 | 13.3 | ||||
| Hypotension | 2 | 13.3 | 2 | 13.3 | ||||||
| Pruritus | 2 | 13.3 | 2 | 13.3 | ||||||
| Dry eye syndrome | 1 | 6.7 | 1 | 6.7 | ||||||