Table 2 Summary of studies in which... | American Society of Hematology

Table 2

Summary of studies in which authors evaluated Treg frequencies

Author, y	No. of patients	Time of sampling	Tregs (% of CD4⁺ T cells) in PB		Tregs (% of CD4⁺ T cells) in BM		Comments
Author, y	No. of patients	Time of sampling	Patients	Controls	Patients	Controls	Comments
Wang, 2005	36	At diagnosis	4.1	2	4.9	1.8	Increased Tregs caused by more production over apoptosis Tregs inhibited both autologous and controls' CD4⁺CD25⁻ T cells
Szczepanski, 2009	30	At diagnosis	4.5	1.5			Tregs were functionally immunosuppressive. Higher Treg frequencies were associated with poor prognosis. Relative Treg frequencies remained greater in complete remission
Ersvaer, 2010	20	At diagnosis	∼ 6				Tregs were functionally immunosuppressive. Although Tregs decreased after chemotherapy, its ratio to other T-cell subsets remained high CD4/CD8 ratio remained relatively stable throughout therapy
		During cytopenia	∼ 5.5
		Recovery	∼ 3	∼ 1
Shenghui, 2010	182	At diagnosis	9.2* ∼ 2†	5.4*	11.8* ∼ 5†		There was a strong correlation between CD25⁺CD127^lo and CD25⁺FOXP3⁺ in CD4⁺ T cells whereas correlation between CD25^hi and CD25⁺ FOXP3⁺ in CD4⁺ T cells was weak Tregs were higher in BM than in PB BM Tregs were more immunosuppressive than PB Tregs. Higher Treg frequencies were associated with poor prognosis
Kanakry, 2011	20	Early recovery after induction chemotherapy	10.5				Tregs were functionally immunosuppressive. Production of Tregs occurred in both periphery and thymus (peripheral > thymus.) Antigen stimulation appeared to be responsible for oligoclonal Treg production. Most of the T cells were CD4⁺ T cells, giving the ratio of 2.7/1 of CD4⁺/CD8⁺ cells

Author, y	No. of patients	Time of sampling	Tregs (% of CD4⁺ T cells) in PB		Tregs (% of CD4⁺ T cells) in BM		Comments
Author, y	No. of patients	Time of sampling	Patients	Controls	Patients	Controls	Comments
Wang, 2005	36	At diagnosis	4.1	2	4.9	1.8	Increased Tregs caused by more production over apoptosis Tregs inhibited both autologous and controls' CD4⁺CD25⁻ T cells
Szczepanski, 2009	30	At diagnosis	4.5	1.5			Tregs were functionally immunosuppressive. Higher Treg frequencies were associated with poor prognosis. Relative Treg frequencies remained greater in complete remission
Ersvaer, 2010	20	At diagnosis	∼ 6				Tregs were functionally immunosuppressive. Although Tregs decreased after chemotherapy, its ratio to other T-cell subsets remained high CD4/CD8 ratio remained relatively stable throughout therapy
		During cytopenia	∼ 5.5
		Recovery	∼ 3	∼ 1
Shenghui, 2010	182	At diagnosis	9.2* ∼ 2†	5.4*	11.8* ∼ 5†		There was a strong correlation between CD25⁺CD127^lo and CD25⁺FOXP3⁺ in CD4⁺ T cells whereas correlation between CD25^hi and CD25⁺ FOXP3⁺ in CD4⁺ T cells was weak Tregs were higher in BM than in PB BM Tregs were more immunosuppressive than PB Tregs. Higher Treg frequencies were associated with poor prognosis
Kanakry, 2011	20	Early recovery after induction chemotherapy	10.5				Tregs were functionally immunosuppressive. Production of Tregs occurred in both periphery and thymus (peripheral > thymus.) Antigen stimulation appeared to be responsible for oligoclonal Treg production. Most of the T cells were CD4⁺ T cells, giving the ratio of 2.7/1 of CD4⁺/CD8⁺ cells

These studies revealed that patients with AML had higher Treg levels compared with HC. The frequencies of Tregs were mostly investigated in PB. One study revealed the frequency of Tregs was higher in the BM compared with PB. Two of the studies indicated higher Treg levels at diagnosis were associated with poor prognosis.

∼ indicates that absolute numbers were not provided by the articles, but the approximate numbers were estimated from figures; AML, acute myelogenous leukemia; HC, healthy controls; and PB, peripheral blood.

CD4⁺CD25⁺CD127^lo T cells.

†

CD4⁺CD25^high T cells.

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