PK parameters of barasertib and barasertib-hQPA following a 7-day infusion of barasertib 1200 mg in part B
| PK parameter . | Geometric mean (CV, %) [n] . | |
|---|---|---|
| Barasertib (n = 32) . | Barasertib-hQPA (n = 32) . | |
| Css, ng/mL | 87.4 (46.2) [13] | 245.2 (22.7) [15] |
| AUC, ng/h/mL | NC | 40 930 (20.7) [12] |
| AUC0–192h, ng/h/mL | 14 030 (46.0) [13]* | 39 300 (22.3) [15] |
| CL, L/h | NC | 29.3 (22.8) [12] |
| Vss, L | NC | 614.2 (42.7) [12] |
| Vz, L | NC | 3278 (44.1) [12] |
| t1/2, h | NC | 77.5 (34.6) [12] |
| PK parameter . | Geometric mean (CV, %) [n] . | |
|---|---|---|
| Barasertib (n = 32) . | Barasertib-hQPA (n = 32) . | |
| Css, ng/mL | 87.4 (46.2) [13] | 245.2 (22.7) [15] |
| AUC, ng/h/mL | NC | 40 930 (20.7) [12] |
| AUC0–192h, ng/h/mL | 14 030 (46.0) [13]* | 39 300 (22.3) [15] |
| CL, L/h | NC | 29.3 (22.8) [12] |
| Vss, L | NC | 614.2 (42.7) [12] |
| Vz, L | NC | 3278 (44.1) [12] |
| t1/2, h | NC | 77.5 (34.6) [12] |
NC indicates not calculable.
AUC0-192h for barasertib.