Clinical characteristics of the patients
Patient . | Sex/age, y . | Age at diagnosis, y . | Phase and BCR-ABL transcript at diagnosis . | Treatment 1 . | Treatment 2 . | Treatment discontinuation . | BCR-ABL undetectability (blood samples) . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment . | Duration, y . | Yes/no . | Treatment . | Duration, y . | Yes/no . | Age at discontinuation, y . | Off-therapy duration, y . | Duration, y . | ||||
1 | F/66.7 | 43 | CP, b3a2 | IFN-α | 13.3 | No | Yes | 55.4 | 11.3 | 5.1 | ||
2 | M/71.8 | 46 | CP, b3a2 | IFN-α | 9.1 | No | Yes | 55.1 | 16.7 | 4.3 | ||
3 | F/72.3 | 57.5 | CP, b3a2 | IFN-α | 6.5 | No | Yes | 64 | 8.3 | 5.8 | ||
4 | F/69.2 | 58.1 | CP, b3a2 | IFN-α | 4.0 | Yes | IM 400 | 4.6 | Yes | 66.8 | 2.3 | 4.0 |
5 | F/70 | 61.6 | CP, b3a2 | IFN-α | 1.3 | Yes | IM 400 | 5.0 | Yes | 68.1 | 1.9 | 5.1 |
6 | F/78.5 | 74 | CP, b3a2 | IM 400 | 4 months | Yes | Dasatinib* | 4 | No | 3.2 |
Patient . | Sex/age, y . | Age at diagnosis, y . | Phase and BCR-ABL transcript at diagnosis . | Treatment 1 . | Treatment 2 . | Treatment discontinuation . | BCR-ABL undetectability (blood samples) . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment . | Duration, y . | Yes/no . | Treatment . | Duration, y . | Yes/no . | Age at discontinuation, y . | Off-therapy duration, y . | Duration, y . | ||||
1 | F/66.7 | 43 | CP, b3a2 | IFN-α | 13.3 | No | Yes | 55.4 | 11.3 | 5.1 | ||
2 | M/71.8 | 46 | CP, b3a2 | IFN-α | 9.1 | No | Yes | 55.1 | 16.7 | 4.3 | ||
3 | F/72.3 | 57.5 | CP, b3a2 | IFN-α | 6.5 | No | Yes | 64 | 8.3 | 5.8 | ||
4 | F/69.2 | 58.1 | CP, b3a2 | IFN-α | 4.0 | Yes | IM 400 | 4.6 | Yes | 66.8 | 2.3 | 4.0 |
5 | F/70 | 61.6 | CP, b3a2 | IFN-α | 1.3 | Yes | IM 400 | 5.0 | Yes | 68.1 | 1.9 | 5.1 |
6 | F/78.5 | 74 | CP, b3a2 | IM 400 | 4 months | Yes | Dasatinib* | 4 | No | 3.2 |
CP indicates chronic phase; and IM 400, imatinib 400 mg daily.
Dasatinib 70 mg twice daily and then 100 mg twice daily.