Table 2 Reversal of MDS and cytogenetic... | American Society of Hematology

Table 2

Reversal of MDS and cytogenetic abnormalities after HSCT

Patient no.	Time point, y	Pretransplantation BM			Posttransplantation BM
Patient no.	Time point, y	Cellularity, %	BM content	Cytogenetics	Cellularity, %	BM content	Cytogenetics
1	2	40-60	Atypical megakaryocytes, 10%-15% plasma cells	Normal	40-60	Trilineage hematopoiesis, 8%-10% plasma cells	Normal
2	0.2	50	↑Megakaryocytes, Dysplasia, ? clonal LGL	ND	30	↓ Megakaryocytes, hemophagocytic macrophages	ND
3	0.6	5-20	Markedly hypocellular with trilineage hypoplasia	−Y	60	Normal marrow	Normal
4	0.6	30-60	↓ Atypical megakaryocytes, focal ↑ blasts	+8	40-50	Trilineage hematopoiesis	Normal
5	1.0	50-60	Atypical megakaryocytes, 10% myeloblasts	−6	10-60	Few atypical megakaryocytes, < 5% blasts	Normal
6	0.6	40-60	Atypical megakaryocytes, mild dysplasia	−7	10-20	Trilineage hypoplasia, no ↑ blasts	Normal

Patient no.	Time point, y	Pretransplantation BM			Posttransplantation BM
Patient no.	Time point, y	Cellularity, %	BM content	Cytogenetics	Cellularity, %	BM content	Cytogenetics
1	2	40-60	Atypical megakaryocytes, 10%-15% plasma cells	Normal	40-60	Trilineage hematopoiesis, 8%-10% plasma cells	Normal
2	0.2	50	↑Megakaryocytes, Dysplasia, ? clonal LGL	ND	30	↓ Megakaryocytes, hemophagocytic macrophages	ND
3	0.6	5-20	Markedly hypocellular with trilineage hypoplasia	−Y	60	Normal marrow	Normal
4	0.6	30-60	↓ Atypical megakaryocytes, focal ↑ blasts	+8	40-50	Trilineage hematopoiesis	Normal
5	1.0	50-60	Atypical megakaryocytes, 10% myeloblasts	−6	10-60	Few atypical megakaryocytes, < 5% blasts	Normal
6	0.6	40-60	Atypical megakaryocytes, mild dysplasia	−7	10-20	Trilineage hypoplasia, no ↑ blasts	Normal

MDS indicates myelodysplastic syndrome; ND, not done; and LGL, large granular lymphocyte.