Trabecular morphologic parameters in the tibia of untreated, PTH-treated, and PTH + ALN-treated mice measured by micro-CT analysis
| . | Untreated . | PTH-treated . | P . | PTH + ALN-treated . | P . |
|---|---|---|---|---|---|
| TV, mm3 | 1.86 ± 0.13 | 2.44 ± 0.20 | < .001 | 2.44 ± 0.13 | < .001 |
| BV, mm3 | 0.20 ± 0.026 | 0.39 ± 0.082 | < .001 | 0.71 ± 0.105 | < .001 |
| BV/TV | 10.82 ± 0.85 | 15.47 ± 2.05 | < .001 | 29.21 ± 3.30 | < .001 |
| TS, mm2 | 12.17 ± 0.88 | 15.19 ± 0.86 | < .001 | 14.97 ± 1.26 | < .001 |
| BS, mm2 | 16.71 ± 1.51 | 33.53 ± 3.33 | < .001 | 49.20 ± 8.23 | < .001 |
| BS/TV, 1/mm | 8.99 ± 0.47 | 13.67 ± 1.75 | < .001 | 20.11 ± 2.64 | < .001 |
| Tb.Th, mm | 0.049 ± 0.003 | 0.05 ± 0.004 | .66 | 0.053 ± 0.003 | < .05 |
| Tb.Sp, mm | 0.26 ± 0.013 | 0.22 ± 0.027 | < .001 | 0.19 ± 0.034 | < .001 |
| Tb.N, 1/mm | 2.21 ± 0.26 | 3.30 ± 0.42 | < .001 | 5.51 ± 0.68 | < .001 |
| Tb.Pf, 1/mm | 20.03 ± 2.28 | 12.4 ± 5.45 | < .01 | 12.1 ± 5.23 | < .001 |
| . | Untreated . | PTH-treated . | P . | PTH + ALN-treated . | P . |
|---|---|---|---|---|---|
| TV, mm3 | 1.86 ± 0.13 | 2.44 ± 0.20 | < .001 | 2.44 ± 0.13 | < .001 |
| BV, mm3 | 0.20 ± 0.026 | 0.39 ± 0.082 | < .001 | 0.71 ± 0.105 | < .001 |
| BV/TV | 10.82 ± 0.85 | 15.47 ± 2.05 | < .001 | 29.21 ± 3.30 | < .001 |
| TS, mm2 | 12.17 ± 0.88 | 15.19 ± 0.86 | < .001 | 14.97 ± 1.26 | < .001 |
| BS, mm2 | 16.71 ± 1.51 | 33.53 ± 3.33 | < .001 | 49.20 ± 8.23 | < .001 |
| BS/TV, 1/mm | 8.99 ± 0.47 | 13.67 ± 1.75 | < .001 | 20.11 ± 2.64 | < .001 |
| Tb.Th, mm | 0.049 ± 0.003 | 0.05 ± 0.004 | .66 | 0.053 ± 0.003 | < .05 |
| Tb.Sp, mm | 0.26 ± 0.013 | 0.22 ± 0.027 | < .001 | 0.19 ± 0.034 | < .001 |
| Tb.N, 1/mm | 2.21 ± 0.26 | 3.30 ± 0.42 | < .001 | 5.51 ± 0.68 | < .001 |
| Tb.Pf, 1/mm | 20.03 ± 2.28 | 12.4 ± 5.45 | < .01 | 12.1 ± 5.23 | < .001 |
Data are mean ± SEM; n = 4.
TS indicates tissue surface; BS, bone surface; BS/TV, percentage of bone surface; BV/TV, percentage of bone volume; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Tb.N, trabecular number; and Tb.Pf, trabecular pattern factor.