Trabecular morphologic parameters as defined by micro-CT analysis in tibias of mice treated with ALN for 4 weeks
| . | Untreated . | ALN-treated . | P . |
|---|---|---|---|
| TV, mm3 | 1.59 ± 0.18 | 1.68 ± 0.10 | .48 |
| BV, mm3 | 0.17 ± 0.04 | 0.48 ± 0.02 | < .001 |
| BV/TV | 10.36 ± 1.55 | 28.54 ± 1.41 | < .001 |
| TS, mm2 | 10.01 ± 0.84 | 10.14 ± 0.21 | .8 |
| BS, mm2 | 14.8 ± 0.39 | 33.68 ± 1.02 | < .001 |
| BS/TV, 1/mm | 9.21 ± 1.72 | 20.04 ± 0.69 | < .001 |
| Tb.Th, mm | 0.046 ± 0.003 | 0.051 ± 0.001 | < .05 |
| Tb.Sp, mm | 0.24 ± 0.043 | 0.16 ± 0.014 | < .05 |
| Tb.N, 1/mm | 2.29 ± 0.47 | 5.65 ± 0.19 | < .001 |
| Tb.Pf, 1/mm | 28.13 ± 0.99 | 6.51 ± 1.6 | < .001 |
| . | Untreated . | ALN-treated . | P . |
|---|---|---|---|
| TV, mm3 | 1.59 ± 0.18 | 1.68 ± 0.10 | .48 |
| BV, mm3 | 0.17 ± 0.04 | 0.48 ± 0.02 | < .001 |
| BV/TV | 10.36 ± 1.55 | 28.54 ± 1.41 | < .001 |
| TS, mm2 | 10.01 ± 0.84 | 10.14 ± 0.21 | .8 |
| BS, mm2 | 14.8 ± 0.39 | 33.68 ± 1.02 | < .001 |
| BS/TV, 1/mm | 9.21 ± 1.72 | 20.04 ± 0.69 | < .001 |
| Tb.Th, mm | 0.046 ± 0.003 | 0.051 ± 0.001 | < .05 |
| Tb.Sp, mm | 0.24 ± 0.043 | 0.16 ± 0.014 | < .05 |
| Tb.N, 1/mm | 2.29 ± 0.47 | 5.65 ± 0.19 | < .001 |
| Tb.Pf, 1/mm | 28.13 ± 0.99 | 6.51 ± 1.6 | < .001 |
Data are mean ± SEM; n = 4.
TS indicates tissue surface; BS, bone surface; BS/TV, percentage of bone surface; BV/TV, percentage of bone volume; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Tb.N, trabecular number; and Tb.Pf, trabecular pattern factor.