Personal history of inflammatory conditions and risk of MM and MGUS
| Category or condition . | MM . | MGUS . | ||||
|---|---|---|---|---|---|---|
| MM patients (n = 19 112) . | Controls (n = 75 408) . | OR (95% CI) . | MGUS patients (n = 5403) . | Controls (n = 21 209) . | OR (95% CI) . | |
| Total inflammatory conditions* | 1079 | 4021 | 1.1 (0.99-1.1) | 617 | 1843 | 1.4 (1.2-1.5) |
| Chronic bronchitis | 115 | 572 | 0.8 (0.6-0.96) | 69 | 259 | 1.0 (0.8-1.4) |
| Nephrotic syndrome | 13 | 14 | 3.7 (1.7-7.8) | 12 | 10 | 4.7 (2.1-11.0) |
| Chronic glomerulonephritis | 20 | 59 | 1.3 (0.8-2.2) | 19 | 32 | 2.4 (1.3-4.2) |
| Chronic prostatitis | 10 | 55 | 0.7 (0.4-1.4) | 11 | 25 | 1.7 (0.9-3.5) |
| Dermatitis herpetiformis | 3 | 8 | 1.5 (0.4-5.6) | 1 | 5 | 0.8 (0.1-6.7) |
| Pemphigus | 1 | 11 | 0.4 (0.0-2.8) | 2 | 1 | 7.8 (0.7-85.4) |
| Chronic atrophic gastritis | 2 | 22 | 0.4 (0.1-1.5) | 5 | 11 | 1.8 (0.6-5.1) |
| Pancreatitis | 76 | 346 | 0.9 (0.7-1.1) | 42 | 166 | 1.0 (0.7-1.4) |
| Acute nephritis | 8 | 17 | 1.9 (0.8-4.3) | 10 | 17 | 2.3 (1.1-5.1) |
| Chronic osteoarthritis | 695 | 2499 | 1.1 (1.00-1.2) | 383 | 1117 | 1.4 (1.2-1.6) |
| Diverticulitis | 186 | 617 | 1.2 (1.00-1.4) | 108 | 322 | 1.3 (1.1-1.6) |
| Category or condition . | MM . | MGUS . | ||||
|---|---|---|---|---|---|---|
| MM patients (n = 19 112) . | Controls (n = 75 408) . | OR (95% CI) . | MGUS patients (n = 5403) . | Controls (n = 21 209) . | OR (95% CI) . | |
| Total inflammatory conditions* | 1079 | 4021 | 1.1 (0.99-1.1) | 617 | 1843 | 1.4 (1.2-1.5) |
| Chronic bronchitis | 115 | 572 | 0.8 (0.6-0.96) | 69 | 259 | 1.0 (0.8-1.4) |
| Nephrotic syndrome | 13 | 14 | 3.7 (1.7-7.8) | 12 | 10 | 4.7 (2.1-11.0) |
| Chronic glomerulonephritis | 20 | 59 | 1.3 (0.8-2.2) | 19 | 32 | 2.4 (1.3-4.2) |
| Chronic prostatitis | 10 | 55 | 0.7 (0.4-1.4) | 11 | 25 | 1.7 (0.9-3.5) |
| Dermatitis herpetiformis | 3 | 8 | 1.5 (0.4-5.6) | 1 | 5 | 0.8 (0.1-6.7) |
| Pemphigus | 1 | 11 | 0.4 (0.0-2.8) | 2 | 1 | 7.8 (0.7-85.4) |
| Chronic atrophic gastritis | 2 | 22 | 0.4 (0.1-1.5) | 5 | 11 | 1.8 (0.6-5.1) |
| Pancreatitis | 76 | 346 | 0.9 (0.7-1.1) | 42 | 166 | 1.0 (0.7-1.4) |
| Acute nephritis | 8 | 17 | 1.9 (0.8-4.3) | 10 | 17 | 2.3 (1.1-5.1) |
| Chronic osteoarthritis | 695 | 2499 | 1.1 (1.00-1.2) | 383 | 1117 | 1.4 (1.2-1.6) |
| Diverticulitis | 186 | 617 | 1.2 (1.00-1.4) | 108 | 322 | 1.3 (1.1-1.6) |
Overall category totals more than the sum of the individual categories because some of the patients have > 1 type of inflammatory condition.