Table 1 B-cell populations with deletion... | American Society of Hematology

Table 1

B-cell populations with deletion efficiencies in Notch2IC//CD19Cre^+/− and control mice

	BM (n = 7)				Spleen (n = 10)
	IgM⁻ B220^low CD43⁺ pro-B	IgM⁻ B220^low CD43⁻ pre-B	B220⁺ IgM⁺ IgD⁻ immature B	B220⁺ IgM⁺ IgD⁺ mature B	AA4.1⁺ IgM⁺ T B	AA4.1⁺ IgM^high CD23⁻ T1 B	AA4.1⁺ IgM^high CD23⁺ T2 B	AA4.1⁺ IgM^low CD23⁺ T3 B	B220⁺ CD21^int CD23⁺ Fo B	B220⁺ CD21^high CD23⁻ MZ B
Control, mean ± SD, %	8 ± 2	36 ± 12	15 ± 3	20 ± 3	17 ± 8	23 ± 5	40 ± 6	19 ± 3	73 ± 4	8 ± 3
Notch2IC//CD19Cre^+/−, mean ± SD, %	8 ± 2	29 ± 13	18 ± 2	7 ± 3†	17 ± 5	39 ± 9†	34 ± 10*	11 ± 3†	13 ± 4†	65 ± 5†
Control, mean ± SD, × 10⁵	1.8 ± 0.6	7.9 ± 2.9	3.1 ± 1.0	4.2 ± 0.5	4.3 ± 1.6	1.4 ± 0.6	2.3 ± 0.7	1.1 ± 0.4	22.0 ± 8.5	2.4 ± 1.2
Notch2IC//CD19Cre^+/−, mean ± SD, × 10⁵	1.4 ± 0.6	5.2 ± 2.1	2.3 ± 0.8	0.9 ± 0.2†	5.9 ± 2.6	2.6 ± 1.4*	2.1 ± 0.9	0.7 ± 0.2*	4.2 ± 3.0†	17.6 ± 7.8†
Notch2IC//CD19Cre^+/−, mean ± SD, % hCD2⁺	9 ± 2	9 ± 2	42 ± 4	57 ± 9	58 ± 7	70 ± 9	58 ± 12	49 ± 7	26 ± 8	95 ± 2

	BM (n = 7)				Spleen (n = 10)
	IgM⁻ B220^low CD43⁺ pro-B	IgM⁻ B220^low CD43⁻ pre-B	B220⁺ IgM⁺ IgD⁻ immature B	B220⁺ IgM⁺ IgD⁺ mature B	AA4.1⁺ IgM⁺ T B	AA4.1⁺ IgM^high CD23⁻ T1 B	AA4.1⁺ IgM^high CD23⁺ T2 B	AA4.1⁺ IgM^low CD23⁺ T3 B	B220⁺ CD21^int CD23⁺ Fo B	B220⁺ CD21^high CD23⁻ MZ B
Control, mean ± SD, %	8 ± 2	36 ± 12	15 ± 3	20 ± 3	17 ± 8	23 ± 5	40 ± 6	19 ± 3	73 ± 4	8 ± 3
Notch2IC//CD19Cre^+/−, mean ± SD, %	8 ± 2	29 ± 13	18 ± 2	7 ± 3†	17 ± 5	39 ± 9†	34 ± 10*	11 ± 3†	13 ± 4†	65 ± 5†
Control, mean ± SD, × 10⁵	1.8 ± 0.6	7.9 ± 2.9	3.1 ± 1.0	4.2 ± 0.5	4.3 ± 1.6	1.4 ± 0.6	2.3 ± 0.7	1.1 ± 0.4	22.0 ± 8.5	2.4 ± 1.2
Notch2IC//CD19Cre^+/−, mean ± SD, × 10⁵	1.4 ± 0.6	5.2 ± 2.1	2.3 ± 0.8	0.9 ± 0.2†	5.9 ± 2.6	2.6 ± 1.4*	2.1 ± 0.9	0.7 ± 0.2*	4.2 ± 3.0†	17.6 ± 7.8†
Notch2IC//CD19Cre^+/−, mean ± SD, % hCD2⁺	9 ± 2	9 ± 2	42 ± 4	57 ± 9	58 ± 7	70 ± 9	58 ± 12	49 ± 7	26 ± 8	95 ± 2

BM cells were isolated from one tibia bone per mouse. Percentages within the lymphocyte gate are shown.

P <.05 in comparison to control.

P < .001 in comparison to control.