Response to therapy and outcome according to IDH2 genotype
| . | 5 years . | 10 years . | Univariable analysis . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IDH1/2WT . | IDH1MUT . | IDH2R140 . | IDH2R172 . | IDH1/2WT . | IDH1MUT . | IDH2R140 . | IDH2R172 . | 4-way P . | OR or HR (95% CI) (IDH2R140 vs IDH2R172 vs IDH1/2WT) . | ||
| CR, % | 75 | 81 | 88 | 48 | NA | NA | NA | NA | < .0001 | R140: OR = 0.41 (0.23-0.73) R172: OR = 3.15 (1.50-6.59) P < .0001 | |
| CR/CRi, % | 82 | 81 | 92 | 79 | NA | NA | NA | NA | .03 | R140: OR = 0.40 (0.20-0.81) R172: OR = 1.23 (0.49-3.05) P = .01 | |
| RD, % | 11 | 11 | 4 | 14 | NA | NA | NA | NA | .11 | R140: OR = 0.38 (0.15-0.96) R172: OR = 1.34 (0.46-3.90) P = .05 | |
| ID, % | 7 | 8 | 4 | 7 | NA | NA | NA | NA | .5 | R140: OR = 0.50 (0.18-1.38) R172: OR = 1.01 (0.24-4.33) P = .3 | |
| OS, % | 37 | 38 | 57 | 24 | 33 | 34 | 46 | 9 | .001 | R140: HR = 0.65 (0.50-0.84) R172: HR = 1.40 (0.95-2.07) P = .0004 | |
| CIR, % | 50 | 49 | 28 | 70 | 51 | 55 | 35 | 70 | .0003 | R140: HR = 0.53 (0.38-0.74) R172: HR = 1.31 (0.80-2.16) P = .0001 | |
| . | 5 years . | 10 years . | Univariable analysis . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IDH1/2WT . | IDH1MUT . | IDH2R140 . | IDH2R172 . | IDH1/2WT . | IDH1MUT . | IDH2R140 . | IDH2R172 . | 4-way P . | OR or HR (95% CI) (IDH2R140 vs IDH2R172 vs IDH1/2WT) . | ||
| CR, % | 75 | 81 | 88 | 48 | NA | NA | NA | NA | < .0001 | R140: OR = 0.41 (0.23-0.73) R172: OR = 3.15 (1.50-6.59) P < .0001 | |
| CR/CRi, % | 82 | 81 | 92 | 79 | NA | NA | NA | NA | .03 | R140: OR = 0.40 (0.20-0.81) R172: OR = 1.23 (0.49-3.05) P = .01 | |
| RD, % | 11 | 11 | 4 | 14 | NA | NA | NA | NA | .11 | R140: OR = 0.38 (0.15-0.96) R172: OR = 1.34 (0.46-3.90) P = .05 | |
| ID, % | 7 | 8 | 4 | 7 | NA | NA | NA | NA | .5 | R140: OR = 0.50 (0.18-1.38) R172: OR = 1.01 (0.24-4.33) P = .3 | |
| OS, % | 37 | 38 | 57 | 24 | 33 | 34 | 46 | 9 | .001 | R140: HR = 0.65 (0.50-0.84) R172: HR = 1.40 (0.95-2.07) P = .0004 | |
| CIR, % | 50 | 49 | 28 | 70 | 51 | 55 | 35 | 70 | .0003 | R140: HR = 0.53 (0.38-0.74) R172: HR = 1.31 (0.80-2.16) P = .0001 | |
WT indicates wild-type; MUT, mutant; CR, compete remission; CRi, CR with incomplete hematologic recovery; RD, resistant disease; ID, induction death; NA, not applicable; OR, odds ratio; HR, hazard ratio; and CI, confidence interval.