Distribution of events in the randomly assigned patients with B-precursor acute lymphoblastic leukemia
| . | PO MTX, n . | IV MTX, n . | SDI, n . | DDI, n . |
|---|---|---|---|---|
| Isolated BM relapse | 43 | 51 | 42 | 52 |
| Isolated CNS relapse | 26 | 11 | 21 | 16 |
| BM + CNS | 10 | 5 | 8 | 7 |
| BM + EM | 4 | 3 | 2 | 5 |
| Testicular | 7 | 0 | 4 | 3 |
| Other EM | 6 | 2 | 5 | 3 |
| Death as first event | 5 | 1 | 3 | 3 |
| Total | 101 | 73 | 85 | 89 |
| . | PO MTX, n . | IV MTX, n . | SDI, n . | DDI, n . |
|---|---|---|---|---|
| Isolated BM relapse | 43 | 51 | 42 | 52 |
| Isolated CNS relapse | 26 | 11 | 21 | 16 |
| BM + CNS | 10 | 5 | 8 | 7 |
| BM + EM | 4 | 3 | 2 | 5 |
| Testicular | 7 | 0 | 4 | 3 |
| Other EM | 6 | 2 | 5 | 3 |
| Death as first event | 5 | 1 | 3 | 3 |
| Total | 101 | 73 | 85 | 89 |
PO indicates oral; MTX, methotrexate; SDI, single delayed intensification phase; DDI, double delayed intensification phase; and EM, extramedullary site relapse.