Table 4 CVID patients with elevated... | American Society of Hematology

Table 4

CVID patients with elevated pre-B-I precursors show significantly reduced peripheral B-cell counts and a tendency to more nodular T-cell infiltrates in BM

	Pre-B-I normal (n = 16)	Pre-B-I high* (n = 9)	P†
Freiburg classification groups Ia, Ib, and II	Ia: 6	Ia: 6	NS
	Ib: 9	Ib: 3
	II: 1
Pre-B-II, %	51.5‡	6	< .001
Immature B, %	24	7	< .001
Peripheral CD19⁺, 1/μL	190	50	.003
Peripheral transitional B cells, 1/μL	5.3	0.2	.002
Peripheral CD4/CD8 ratio	1.9	1.7	NS
Peripheral CD45RO⁺ in CD4⁺ T cells, %	74.4	63.7	NS
sIL-2R, U/mL	1033	1503	NS
CD3⁺ T-cell nodules/mm BM biopsy	0.1	0.3	NS (.1)

	Pre-B-I normal (n = 16)	Pre-B-I high* (n = 9)	P†
Freiburg classification groups Ia, Ib, and II	Ia: 6	Ia: 6	NS
	Ib: 9	Ib: 3
	II: 1
Pre-B-II, %	51.5‡	6	< .001
Immature B, %	24	7	< .001
Peripheral CD19⁺, 1/μL	190	50	.003
Peripheral transitional B cells, 1/μL	5.3	0.2	.002
Peripheral CD4/CD8 ratio	1.9	1.7	NS
Peripheral CD45RO⁺ in CD4⁺ T cells, %	74.4	63.7	NS
sIL-2R, U/mL	1033	1503	NS
CD3⁺ T-cell nodules/mm BM biopsy	0.1	0.3	NS (.1)

NS indicates not significant.

Patients with a percentage of pre-B-I cells > 25% were classified as pre-B-I high.

†

Wilcoxon test (2-sided P values).

‡

Median values.

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