Table 4 Multivariate linear regression... | American Society of Hematology

Table 4

Multivariate linear regression analysis of s₁ for CD4 and CD8 T-cell subsets with baseline CD4 T-cell count and baseline VL (log₁₀) as covariates

	CD4 naive s₁	CD8 naive s₁*	CD4 CM s₁	CD8 CM s₁	CD4 EM s₁†	CD8 EM s₁	CD4 Act s₁	CD8 Act s₁
Coefficient of CD4, × 10³ (cells/μL)	−0.021	−0.004	−0.019	−0.01	−0.067	−0.008	−0.124	−0.042
Coefficient of CD4, × 10³ (cells/μL)	(P = .037)	(P = .52)	(P = .16)	(P = .73)	(P = .06)	(P = .41)	(P = .12)	(P = .69)
Coefficient of log₁₀VL, × 10³ (log₁₀ copies/mL)	0.901	2.526	3.522	3.291	12.733	4.613	5.516	−7.615
Coefficient of log₁₀VL, × 10³ (log₁₀ copies/mL)	(P = .44)	(P = .002)	(P = .033)	(P = .33)	(P = .006)	(P< .001)	(P = .56)	(P = .55)
R²	0.217	0.443	0.221	0.051	0.355	0.49	0.125	0.056

	CD4 naive s₁	CD8 naive s₁*	CD4 CM s₁	CD8 CM s₁	CD4 EM s₁†	CD8 EM s₁	CD4 Act s₁	CD8 Act s₁
Coefficient of CD4, × 10³ (cells/μL)	−0.021	−0.004	−0.019	−0.01	−0.067	−0.008	−0.124	−0.042
Coefficient of CD4, × 10³ (cells/μL)	(P = .037)	(P = .52)	(P = .16)	(P = .73)	(P = .06)	(P = .41)	(P = .12)	(P = .69)
Coefficient of log₁₀VL, × 10³ (log₁₀ copies/mL)	0.901	2.526	3.522	3.291	12.733	4.613	5.516	−7.615
Coefficient of log₁₀VL, × 10³ (log₁₀ copies/mL)	(P = .44)	(P = .002)	(P = .033)	(P = .33)	(P = .006)	(P< .001)	(P = .56)	(P = .55)
R²	0.217	0.443	0.221	0.051	0.355	0.49	0.125	0.056

CM indicates central memory; EM, effector memory; and Act, activated.

One patient with very high naive CD8 T-cell estimate for s₁ (38-fold higher than the average, statistically an outlier) was excluded from the CD8 naive analysis. Significant association with the VL is lost with the inclusion of this outlier.

†

One patient with very high effector memory CD4 T-cell estimate for s₁ (24-fold higher than the average, statistically an outlier) was excluded from the CD4 EM analysis. Significant association with the VL is lost with the inclusion of this outlier.

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