Most common MCR observed in the 218 MZL and in the individual subgroups
| Histotype . | Lesion . | Cytoband . | Frequency, % . | Start . | Size . | Correlation with gene expression . |
|---|---|---|---|---|---|---|
| MZL | Gains | 3q11.2-q29 (NFKBIZ, BCL6) | 24 | 9.50 × 107 | 1.04 × 108 | Yes |
| 6q27 | 16 | 1.70 × 108 | 1.01 × 106 | |||
| 13q11-q12.11 | 25 | 1.80 × 107 | 5.33 × 105 | |||
| 18q23 (NFATC1) | 18 | 7.40 × 107 | 2.12 × 106 | Yes | ||
| 21p | 15 | |||||
| Losses | 1p36.21-p36.13 | 12 | 1.51 × 107 | 1.62 × 106 | Yes | |
| 4p12-p11 | 13 | 4.82 × 107 | 5.72 × 105 | |||
| 6q23.2-q24.1 (TNFAIP3) | 16 | 1.35 × 108 | 4.78 × 106 | Yes | ||
| 7q31.31-q32.3 | 17 | 1.20 × 108 | 1.15 × 107 | Yes | ||
| 17p13.3-p13.1 (TP53) | 13 | 1.89 × 104 | 9.71 × 106 | Yes | ||
| MALT lymphoma | Gains | 3q (NFKBIZ, BCL6) | 30 | Yes | ||
| 3p (FOXP1) | 26 | Yes | ||||
| 6p25.1-p21.32 | 14 | 4.35 × 106 | 2.85 × 107 | |||
| 7p15.1 | 14 | 3.15 × 107 | 1.78 × 104 | |||
| 7q11.22 | 18 | 6.88 × 107 | 5.68 × 105 | |||
| 8p21.2 | 14 | 2.72 × 107 | 1.36 × 105 | |||
| 18p | 21 | Yes | ||||
| 18q (BCL2, NFATC1) | 21 | Yes | ||||
| Losses | 1p36.21-p36.13 | 12 | 1.56 × 107 | 1.12 × 106 | Yes | |
| 4p11–12 | 14 | 4.81 × 107 | 6.81 × 105 | |||
| 6q23.3-q24.1 (TNFAIP3) | 30 | 1.37 × 108 | 2.35 × 106 | Yes | ||
| 13q32.1-q32.2 | 16 | 9.69 × 107 | 8.28 × 105 | Yes | ||
| Splenic MZL | Gains | 3q13.13-q29 (NFKBIZ, BCL6) | 20 | 1.10 × 108 | 8.89 × 107 | Yes |
| 6q27 | 19 | 1.70 × 108 | 4.83 × 105 | |||
| 8p23.1-p22 | 15 | 1.23 × 107 | 5.08 × 105 | Yes | ||
| 9q31.1 | 13 | 1.05 × 108 | 3.20 × 104 | |||
| 12q21.31 | 13 | 8.07 × 107 | 4.06 × 104 | |||
| 13q11-q12.11 | 28 | 1.80 × 107 | 5.33 × 105 | |||
| 18q23 (NFATC1) | 15 | 7.35 × 107 | 2.57 × 106 | Yes | ||
| 21p | 17 | |||||
| Losses | 1p36.21-p36.13 | 13 | 1.51 × 107 | 1.62 × 106 | ||
| 4p12-p11 | 13 | 4.82 × 107 | 5.72 × 105 | |||
| 7q31.31-q32.3 | 26 | 1.20 × 108 | 1.15 × 107 | Yes | ||
| 8p | 13 | |||||
| 17p13.3-p13.1 (TP53) | 17 | 1.89 × 104 | 9.71 × 106 | Yes | ||
| Nodal MZL | Gains | 2p16.3 | 20 | 4.95 × 107 | 2.11 × 106 | |
| 3p25.3 | 24 | 1.04 × 107 | 6.06 × 105 | |||
| 3p14.3-q29 (FOXP1, NFKBIZ, BCL6) | 24 | 5.46 × 107 | 1.45 × 108 | Yes | ||
| 6p21.2-p21.1 | 16 | 4.01 × 107 | 1.46 × 106 | |||
| 6q27 | 16 | 1.70 × 108 | 1.04 × 106 | |||
| 18q23 (NFATC1) | 24 | 7.42 × 107 | 1.95 × 106 | Yes | ||
| Losses | 1p36.33-p36.22 | 16 | 7.76 × 105 | 9.76 × 106 | Yes | |
| 1p21.2 | 16 | 9.98 × 107 | 1.86 × 106 | Yes | ||
| 6q23.3 (TNFAIP3) | 16 | 1.37 × 108 | 1.44 × 106 | Yes | ||
| 12q21.33-q23.1 | 16 | 9.07 × 107 | 4.81 × 106 | Yes | ||
| 19p13.3-p12 | 16 | 2.12 × 105 | 1.98 × 107 | Yes |
| Histotype . | Lesion . | Cytoband . | Frequency, % . | Start . | Size . | Correlation with gene expression . |
|---|---|---|---|---|---|---|
| MZL | Gains | 3q11.2-q29 (NFKBIZ, BCL6) | 24 | 9.50 × 107 | 1.04 × 108 | Yes |
| 6q27 | 16 | 1.70 × 108 | 1.01 × 106 | |||
| 13q11-q12.11 | 25 | 1.80 × 107 | 5.33 × 105 | |||
| 18q23 (NFATC1) | 18 | 7.40 × 107 | 2.12 × 106 | Yes | ||
| 21p | 15 | |||||
| Losses | 1p36.21-p36.13 | 12 | 1.51 × 107 | 1.62 × 106 | Yes | |
| 4p12-p11 | 13 | 4.82 × 107 | 5.72 × 105 | |||
| 6q23.2-q24.1 (TNFAIP3) | 16 | 1.35 × 108 | 4.78 × 106 | Yes | ||
| 7q31.31-q32.3 | 17 | 1.20 × 108 | 1.15 × 107 | Yes | ||
| 17p13.3-p13.1 (TP53) | 13 | 1.89 × 104 | 9.71 × 106 | Yes | ||
| MALT lymphoma | Gains | 3q (NFKBIZ, BCL6) | 30 | Yes | ||
| 3p (FOXP1) | 26 | Yes | ||||
| 6p25.1-p21.32 | 14 | 4.35 × 106 | 2.85 × 107 | |||
| 7p15.1 | 14 | 3.15 × 107 | 1.78 × 104 | |||
| 7q11.22 | 18 | 6.88 × 107 | 5.68 × 105 | |||
| 8p21.2 | 14 | 2.72 × 107 | 1.36 × 105 | |||
| 18p | 21 | Yes | ||||
| 18q (BCL2, NFATC1) | 21 | Yes | ||||
| Losses | 1p36.21-p36.13 | 12 | 1.56 × 107 | 1.12 × 106 | Yes | |
| 4p11–12 | 14 | 4.81 × 107 | 6.81 × 105 | |||
| 6q23.3-q24.1 (TNFAIP3) | 30 | 1.37 × 108 | 2.35 × 106 | Yes | ||
| 13q32.1-q32.2 | 16 | 9.69 × 107 | 8.28 × 105 | Yes | ||
| Splenic MZL | Gains | 3q13.13-q29 (NFKBIZ, BCL6) | 20 | 1.10 × 108 | 8.89 × 107 | Yes |
| 6q27 | 19 | 1.70 × 108 | 4.83 × 105 | |||
| 8p23.1-p22 | 15 | 1.23 × 107 | 5.08 × 105 | Yes | ||
| 9q31.1 | 13 | 1.05 × 108 | 3.20 × 104 | |||
| 12q21.31 | 13 | 8.07 × 107 | 4.06 × 104 | |||
| 13q11-q12.11 | 28 | 1.80 × 107 | 5.33 × 105 | |||
| 18q23 (NFATC1) | 15 | 7.35 × 107 | 2.57 × 106 | Yes | ||
| 21p | 17 | |||||
| Losses | 1p36.21-p36.13 | 13 | 1.51 × 107 | 1.62 × 106 | ||
| 4p12-p11 | 13 | 4.82 × 107 | 5.72 × 105 | |||
| 7q31.31-q32.3 | 26 | 1.20 × 108 | 1.15 × 107 | Yes | ||
| 8p | 13 | |||||
| 17p13.3-p13.1 (TP53) | 17 | 1.89 × 104 | 9.71 × 106 | Yes | ||
| Nodal MZL | Gains | 2p16.3 | 20 | 4.95 × 107 | 2.11 × 106 | |
| 3p25.3 | 24 | 1.04 × 107 | 6.06 × 105 | |||
| 3p14.3-q29 (FOXP1, NFKBIZ, BCL6) | 24 | 5.46 × 107 | 1.45 × 108 | Yes | ||
| 6p21.2-p21.1 | 16 | 4.01 × 107 | 1.46 × 106 | |||
| 6q27 | 16 | 1.70 × 108 | 1.04 × 106 | |||
| 18q23 (NFATC1) | 24 | 7.42 × 107 | 1.95 × 106 | Yes | ||
| Losses | 1p36.33-p36.22 | 16 | 7.76 × 105 | 9.76 × 106 | Yes | |
| 1p21.2 | 16 | 9.98 × 107 | 1.86 × 106 | Yes | ||
| 6q23.3 (TNFAIP3) | 16 | 1.37 × 108 | 1.44 × 106 | Yes | ||
| 12q21.33-q23.1 | 16 | 9.07 × 107 | 4.81 × 106 | Yes | ||
| 19p13.3-p12 | 16 | 2.12 × 105 | 1.98 × 107 | Yes |