Frequency of HLH-associated gene mutations by age in North American patients
| Age at referral . | No. of HLH patients . | PRF1 . | UNC13D . | STXBP2 . | STX11 . | RAB27A . | Mutation identified, % . |
|---|---|---|---|---|---|---|---|
| < 1 mo | 58 | 16 | 5 | 0 | 0 | 0 | 45 |
| 2 mo to 1 y | 100 | 23 | 15 | 1 | 0 | 0 | 39 |
| 1-2 y | 55 | 7 | 4 | 0 | 0 | 0 | 20 |
| > 2 y | 263 | 7 | 3 | 2 | 2 | 1 | 6 |
| Age at referral . | No. of HLH patients . | PRF1 . | UNC13D . | STXBP2 . | STX11 . | RAB27A . | Mutation identified, % . |
|---|---|---|---|---|---|---|---|
| < 1 mo | 58 | 16 | 5 | 0 | 0 | 0 | 45 |
| 2 mo to 1 y | 100 | 23 | 15 | 1 | 0 | 0 | 39 |
| 1-2 y | 55 | 7 | 4 | 0 | 0 | 0 | 20 |
| > 2 y | 263 | 7 | 3 | 2 | 2 | 1 | 6 |
Data from Judith Johnson and Kejian Zhang.