Table 2 Significance of under- or... | American Society of Hematology

Table 2

Significance of under- or over-representations of frequently mutated pathways across the 8 ROSE subgroups¹²

ROSE¹² group	TP53/RB1 signaling		B-cell development		Ras signaling		JAK signaling
ROSE¹² group	P	OR	P	OR	P	OR	P	OR
R1	.056	0.21	3.78 × 10⁻⁵*	0.108	.041	0.26	.23	0
R2	.26	0.55	.47	1.7	.0001*	0.056	.14	0
R3	.001*	∞	.18	0.371	.53	0.52	.62	0
R4	.0035	11.4	.065	6.12	.39	1.73	.37	0
R5	.013	0.098	.032	0.22	.49	1.83	.60	0
R6	.019	0.301	.32	0.593	.058	2.58	.14	0
R7	.070	1.78	.20	1.61	1.65 × 10⁻⁵	3.86	1	1.03
R8	.51	1.374	.0015*	12.3	.0005*	0.114	4.15 × 10⁻⁹	2.44

ROSE¹² group	TP53/RB1 signaling		B-cell development		Ras signaling		JAK signaling
ROSE¹² group	P	OR	P	OR	P	OR	P	OR
R1	.056	0.21	3.78 × 10⁻⁵*	0.108	.041	0.26	.23	0
R2	.26	0.55	.47	1.7	.0001*	0.056	.14	0
R3	.001*	∞	.18	0.371	.53	0.52	.62	0
R4	.0035	11.4	.065	6.12	.39	1.73	.37	0
R5	.013	0.098	.032	0.22	.49	1.83	.60	0
R6	.019	0.301	.32	0.593	.058	2.58	.14	0
R7	.070	1.78	.20	1.61	1.65 × 10⁻⁵	3.86	1	1.03
R8	.51	1.374	.0015*	12.3	.0005*	0.114	4.15 × 10⁻⁹	2.44

The P value was calculated using a 2-sided Fisher exact test.

OR indicates odds ratio.

P < .05 (significant) after correction for multiple testing using a Family-wise Error Rate.