Distribution of the genetic subgroups within the response groups in the independent cohort
| . | Normal response . | Type-A defect . | Type-B defect . | Total . |
|---|---|---|---|---|
| Del 17p | 0 (0%) | 5 (100%) | 1 (7%) | 6 (9%) |
| Sole TP53 mutation | 1 (2%) | 0 (0%) | 1 (7%) | 2 (3%) |
| Del 11q | 10 (23%) | 0 (0%) | 8 (53%) | 18 (28%) |
| Absence of del 17p, del 11q, or TP53 mutation | 33 (75%) | 0 (0%) | 5 (33%) | 38 (59%) |
| Total | 44 (100%) | 5 (100%) | 15 (100%) | 64 (100%) |
| Median p53 basal level (95% CI) | 60.71 (55.69-67.83) | 162.60 (115.90-204.70) | 69.09 (61.45-77.65) | |
| Median p53 induction (95% CI) | 149.90 (147.80-183.90) | 98.23 (64.63-147.60) | 91.86 (79.38-129.90) | |
| Median p21 induction (95% CI) | 128.8 (128.50-138.40) | 108.30 (95.87-117.80) | 106.60 (102.40-109.50) |
| . | Normal response . | Type-A defect . | Type-B defect . | Total . |
|---|---|---|---|---|
| Del 17p | 0 (0%) | 5 (100%) | 1 (7%) | 6 (9%) |
| Sole TP53 mutation | 1 (2%) | 0 (0%) | 1 (7%) | 2 (3%) |
| Del 11q | 10 (23%) | 0 (0%) | 8 (53%) | 18 (28%) |
| Absence of del 17p, del 11q, or TP53 mutation | 33 (75%) | 0 (0%) | 5 (33%) | 38 (59%) |
| Total | 44 (100%) | 5 (100%) | 15 (100%) | 64 (100%) |
| Median p53 basal level (95% CI) | 60.71 (55.69-67.83) | 162.60 (115.90-204.70) | 69.09 (61.45-77.65) | |
| Median p53 induction (95% CI) | 149.90 (147.80-183.90) | 98.23 (64.63-147.60) | 91.86 (79.38-129.90) | |
| Median p21 induction (95% CI) | 128.8 (128.50-138.40) | 108.30 (95.87-117.80) | 106.60 (102.40-109.50) |
CI indicates confidence interval.