Table 2 Overview of TP53 mutations in... | American Society of Hematology

Table 2

Overview of TP53 mutations in the first cohort

UPN	Del17p	Mutation (aa)	Type of mutation	Clone size, %	Predicted activity p21, %*	Predicted activity Bax, %*	P21 induction FACS, %	P21 induction MLPA, -fold	Bax induction MLPA, -fold
1	yes	splice site	splice site	80	N/A	N/A	100.88	1.38	1.16
7	no	p.W146_D148delinsC	frameshift	5	0	0	100.96	N/A	N/A
11	yes	p.F134C	missense	75	15.6	10.2	114.52	N/A	N/A
12	no	p.R209KfsX6	frameshift	75	0	0	109.47	N/A	N/A
14	no	p.R283C	missense	50	41.7	51.9	161.92	10.35 normal	3.18 normal
16	no	p.R248Q	missense	10	0	0	151.22	N/A	N/A
19	yes	p.E180_R181delinsD	in frame deletion	90	N/A	N/A	107.55	2.61	1.19
25	yes	p.C238F	missense	40	1.3	4.6	112.46	N/A	N/A
28	no	p.P152L	missense	20	15.7	16.4	170.04	5.09 normal	2.17 normal
31	yes	p.Q167X	nonsense	25			92.33	1.91	1.18
		p.C277F	missense	60	0.5	0
33	yes	p.D281G	missense	90	19.9	13.5	110.37	N/A	N/A
35	no	p.D48VfsX1fs	frameshift	20			110.03	1.80	1.41
		splice site	splice site	20
		p.Y234H	missense	10	0	2.3
		p.I254N	missense	5	10.2	16.8
		p.E349X	nonsense	10
40	yes	p.P87fsX36	frameshift	70	0	0	105.55	N/A	N/A
41	yes	p.G245D	missense	90	3.2	11.9	109.91	N/A	N/A
43	no	p.I162F	missense	95	10.8	13.4	104.61	1.29	1.21
46	yes	p.R110L	missense	60	20.2	8.9	119.66	N/A	N/A
52	yes	p.A138V	missense	100	52.6	25.5	108.43	N/A	N/A
54	yes	p.R248Q	missense	60	0	0	126.33	1.84	1.56
55	yes	p.R273H	missense	85	1.7	2.4	135.83	N/A	N/A
58	no	p.R209KfsX6	frameshift	80	0	0	100.07	N/A	N/A

UPN	Del17p	Mutation (aa)	Type of mutation	Clone size, %	Predicted activity p21, %*	Predicted activity Bax, %*	P21 induction FACS, %	P21 induction MLPA, -fold	Bax induction MLPA, -fold
1	yes	splice site	splice site	80	N/A	N/A	100.88	1.38	1.16
7	no	p.W146_D148delinsC	frameshift	5	0	0	100.96	N/A	N/A
11	yes	p.F134C	missense	75	15.6	10.2	114.52	N/A	N/A
12	no	p.R209KfsX6	frameshift	75	0	0	109.47	N/A	N/A
14	no	p.R283C	missense	50	41.7	51.9	161.92	10.35 normal	3.18 normal
16	no	p.R248Q	missense	10	0	0	151.22	N/A	N/A
19	yes	p.E180_R181delinsD	in frame deletion	90	N/A	N/A	107.55	2.61	1.19
25	yes	p.C238F	missense	40	1.3	4.6	112.46	N/A	N/A
28	no	p.P152L	missense	20	15.7	16.4	170.04	5.09 normal	2.17 normal
31	yes	p.Q167X	nonsense	25			92.33	1.91	1.18
		p.C277F	missense	60	0.5	0
33	yes	p.D281G	missense	90	19.9	13.5	110.37	N/A	N/A
35	no	p.D48VfsX1fs	frameshift	20			110.03	1.80	1.41
		splice site	splice site	20
		p.Y234H	missense	10	0	2.3
		p.I254N	missense	5	10.2	16.8
		p.E349X	nonsense	10
40	yes	p.P87fsX36	frameshift	70	0	0	105.55	N/A	N/A
41	yes	p.G245D	missense	90	3.2	11.9	109.91	N/A	N/A
43	no	p.I162F	missense	95	10.8	13.4	104.61	1.29	1.21
46	yes	p.R110L	missense	60	20.2	8.9	119.66	N/A	N/A
52	yes	p.A138V	missense	100	52.6	25.5	108.43	N/A	N/A
54	yes	p.R248Q	missense	60	0	0	126.33	1.84	1.56
55	yes	p.R273H	missense	85	1.7	2.4	135.83	N/A	N/A
58	no	p.R209KfsX6	frameshift	80	0	0	100.07	N/A	N/A

N/A indicates not applicable.

From IARC database.