Distribution of the genetic subgroups within the response groups in the original cohort
| . | Normal response . | Type-A defect . | Type-B defect . | Total . |
|---|---|---|---|---|
| Del 17p | 1 (3%) | 11 (73%) | 4 (29%) | 16 (27%) |
| Sole TP53 mutation | 3 (10%) | 3 (20%) | 2 (14%) | 8 (14%) |
| Del 11q | 9 (30%) | 0 (0%) | 3 (21%) | 12 (20%) |
| Absence of del 17p, del 11q, or TP53 mutation | 17 (57%) | 1 (7%) | 5 (36%) | 23 (39%) |
| Total | 30 (100%) | 15 (100%) | 14 (100%) | 59 (100%) |
| Median p53 basal level (95% CI) | 65.52 (63.78-75.35) | 148.50 (131.20-271.40) | 60.71 (53.43-70.08) | |
| Median p53 induction (95% CI) | 125.80 (112.00-135.30) | 84.26 (73.46-175.70) | 76.72 (52.75-82.70) | |
| Median p21 induction (95% CI) | 139.40 (136.80-159.50) | 109.90 (104.50-116.40) | 109.00 (104.90-110.60) |
| . | Normal response . | Type-A defect . | Type-B defect . | Total . |
|---|---|---|---|---|
| Del 17p | 1 (3%) | 11 (73%) | 4 (29%) | 16 (27%) |
| Sole TP53 mutation | 3 (10%) | 3 (20%) | 2 (14%) | 8 (14%) |
| Del 11q | 9 (30%) | 0 (0%) | 3 (21%) | 12 (20%) |
| Absence of del 17p, del 11q, or TP53 mutation | 17 (57%) | 1 (7%) | 5 (36%) | 23 (39%) |
| Total | 30 (100%) | 15 (100%) | 14 (100%) | 59 (100%) |
| Median p53 basal level (95% CI) | 65.52 (63.78-75.35) | 148.50 (131.20-271.40) | 60.71 (53.43-70.08) | |
| Median p53 induction (95% CI) | 125.80 (112.00-135.30) | 84.26 (73.46-175.70) | 76.72 (52.75-82.70) | |
| Median p21 induction (95% CI) | 139.40 (136.80-159.50) | 109.90 (104.50-116.40) | 109.00 (104.90-110.60) |
CI indicates confidence interval.