Table 1 The induction of dnEBNA1 forces... | American Society of Hematology

Table 1

The induction of dnEBNA1 forces the loss of EBV from tumor cells over time

Tumor line	Clone	Plasmid copies*	dnEBNA1	Percentage of EBV-negative cells†
Tumor line	Clone	Plasmid copies*	dnEBNA1	Day 6	Day 10	Day 12	Day 20
PTLD1	P1-1	9	Off	1 ± 0	4 ± 2	ND	ND
			On	28 ± 3	37 ± 3
	P5-1	9	Off	2 ± 2	1 ± 1	ND	ND
			On	43 ± 3	46 ± 9
Oku-BL	O2-4	13	Off	2 ± 1	2 ± 0	ND	ND
			On	29 ± 8	55 ± 12
	O5-2	13	Off	2 ± 1	2 ± 0	ND	ND
			On	22 ± 4	45 ± 5
Sav-BL	S1-1	27	Off	ND	ND	4 ± 3	2 ± 1
			On			50 ± 6	79 ± 4
	S14-2	33	Off	ND	ND	< 1	3
			On			67	80
Dante-BL	D7-1	29	Off	ND	ND	1 ± 0	0 ± 0
			On			46 ± 6	48 ± 11
	D8-1	20	Off	ND	ND	4 ± 2	3 ± 1
			On			63 ± 11	68 ± 7

Tumor line	Clone	Plasmid copies*	dnEBNA1	Percentage of EBV-negative cells†
Tumor line	Clone	Plasmid copies*	dnEBNA1	Day 6	Day 10	Day 12	Day 20
PTLD1	P1-1	9	Off	1 ± 0	4 ± 2	ND	ND
			On	28 ± 3	37 ± 3
	P5-1	9	Off	2 ± 2	1 ± 1	ND	ND
			On	43 ± 3	46 ± 9
Oku-BL	O2-4	13	Off	2 ± 1	2 ± 0	ND	ND
			On	29 ± 8	55 ± 12
	O5-2	13	Off	2 ± 1	2 ± 0	ND	ND
			On	22 ± 4	45 ± 5
Sav-BL	S1-1	27	Off	ND	ND	4 ± 3	2 ± 1
			On			50 ± 6	79 ± 4
	S14-2	33	Off	ND	ND	< 1	3
			On			67	80
Dante-BL	D7-1	29	Off	ND	ND	1 ± 0	0 ± 0
			On			46 ± 6	48 ± 11
	D8-1	20	Off	ND	ND	4 ± 2	3 ± 1
			On			63 ± 11	68 ± 7

ND indicates not done.

Average number of plasmids per cell in the absence of dnEBNA1 from 50 to 150 cells.

Average percentage of EBV-negative cells ± SD (3 independent experiments, except clone S14–2, which was done once).