EAR and SMR for leading causes of death by time since diagnosis in 5-year survivors of Hodgkin lymphoma (n = 2633)
| Cause of death . | Years after diagnosis . | Overall . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 5-9 y . | 10-19 y . | ≥ 20 y . | |||||||
| n . | EAR/10 000 PY (95% CI) . | n . | EAR/10 000 PY (95% CI) . | n . | EAR/10 000 PY (95%CI) . | n . | EAR/10 000 PY (95% CI) . | SMR/1000 PY (95% CI) . | |
| All deaths* | 148 | 10.5 (8.7-12.6) | 205 | 7.6 (6.8-9.0) | 147 | 12.6 (10.3-15.1) | 500 | 95.5 (86.1-105.5) | 7.8 (7.2-8.5) |
| Hodgkin lymphoma | 89 | 69.6 (55.9-85.7) | 64 | 28.1 (21.6-35.8) | 22 | 21.7 (13.6-32.9) | 175 | 38.3 (32.4-44.4) | 779.2 (668.0-903.5) |
| All other malignant neoplasms | 21 | 15.8 (9.6-24.5) | 48 | 19.9 (14.4-26.8) | 47 | 43.1 (30.7-58.4) | 116 | 23.9 (19.5-29.0) | 16.8 (13.9-20.1) |
| Leukemia | 7 | 5.3 (2.0-11.1) | 4 | 1.6 (0.3-4.3) | 0 | 11 | 2.3 (1.0-4.2) | 15.5 (7.7-27.7) | |
| All other hematopoietic | 3 | 2.3 (0.4-6.8) | 8 | 3.4 (1.4-6.8) | 10 | 9.7 (4.5-18.0) | 21 | 4.5 (2.7-6.9) | 42.5 (26.3-64.97) |
| Solid tumors | 11 | 8.2 (3.9-15.0 | 36 | 14.9 (10.2-21.0) | 37 | 33.6 (22.7-47.4) | 84 | 17.2 (13.4-21.5) | 14.9 (11.9-18.4) |
| Breast | 1 | 0.8 (0.0-4.3) | 9 | 3.8 (1.7-7.4) | 11 | 10.3 (4.9-18.9) | 21 | 4.4 (2.6-6.8) | 22.3 (13.8-34.1) |
| Buccal cavity/pharynx | 0 | 2 | 0.9 (0.1-3.2) | 0 | 2 | 0.4 (0.0-1.6) | 17.9 (2.01-64.5) | ||
| Lung/bronchus/trachea | 1 | 0.8 (0-4.3) | 4 | 1.7 (0.4-4.4) | 10 | 9.3 (4.2-17.6) | 15 | 3.1 (1.7-5.2) | 19.4 (10.9-32.0) |
| Digestive organs/peritoneum | 2 | 1.5 (0.1-5.6) | 10 | 4.2 (1.9-7.9) | 9 | 8.2 (3.4-16.2) | 21 | 4.4 (2.6-6.8) | 18.7 (11.6-28.6) |
| CNS | 2 | 1.5 (0.1-5.6) | 4 | 1.6 (0.4-4.4) | 1 | 0.8 (−0.2 to 5.3) | 7 | 1.4 (0.5-3.0) | 12.0 (4.89-24.6) |
| Kidney | 0 | 1 | 0.4 (0.0-2.4) | 0 | 1 | 0.2 (0.0-1.2) | 8.4 (0.1-46.8) | ||
| Melanoma | 1 | 0.8 (0-4.3) | 0 | 1 | 0.9 (−0.1 to 5.4) | 2 | 0.4 (0.0-1.5) | 6.3 (0.7-22.9) | |
| Others | 4 | 3.1 (0.8-7.9) | 6 | 2.5 (0.8-5.6) | 5 | 4.6 (1.3-11.2) | 15 | 3.1 (1.7-5.3) | 21.4 (12.0-35.3) |
| Benign neoplasms | 2 | 1.5 (0.1-5.6) | 1 | 0.4 (0-2.4) | 1 | 0.9 (0.0-5.5) | 4 | 0.8 (0.2-2.2) | 23.7 (6.4-60.6) |
| Cerebrovascular disease | 2 | 0.7 (0.1-3.0) | 3 | 2.4 (0.1-8.1) | 5 | 0.9 (0.1-2.3) | 4.6 (1.5-10.7) | ||
| All heart disease | 7 | 5.1 (1.8-10.9) | 30 | 12.3 (8.0-18.0) | 28 | 25.0 (15.7-37.3) | 65 | 13.1 (9.9-17.0) | 12.7 (9.8-16.2) |
| Ischemic heart disease | 4 | 3.1 (0.8-7.9) | 20 | 8.5 (5.1-13.3) | 13 | 11.4 (5.4-20.5) | 37 | 7.6 (5.2-10.7) | 16.5 (11.6-22.8) |
| Chronic endocardial, other myocardial insufficiency | 2 | 1.5 (0.2-5.6) | 5 | 2.1 (0.7-5.1) | 8 | 7.8 (3.3-15.5) | 15 | 3.2 (1.8-5.4) | 62.4 (34.9-102.92) |
| Nonmalignant respiratory disease | 5 | 3.7 (1.1-8.9) | 12 | 5.0 (2.4-8.9) | 5 | 4.4 (1.0-10.9) | 22 | 4.5 (2.7-7.0) | 14.2 (8.9-21.5) |
| Cause of death . | Years after diagnosis . | Overall . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 5-9 y . | 10-19 y . | ≥ 20 y . | |||||||
| n . | EAR/10 000 PY (95% CI) . | n . | EAR/10 000 PY (95% CI) . | n . | EAR/10 000 PY (95%CI) . | n . | EAR/10 000 PY (95% CI) . | SMR/1000 PY (95% CI) . | |
| All deaths* | 148 | 10.5 (8.7-12.6) | 205 | 7.6 (6.8-9.0) | 147 | 12.6 (10.3-15.1) | 500 | 95.5 (86.1-105.5) | 7.8 (7.2-8.5) |
| Hodgkin lymphoma | 89 | 69.6 (55.9-85.7) | 64 | 28.1 (21.6-35.8) | 22 | 21.7 (13.6-32.9) | 175 | 38.3 (32.4-44.4) | 779.2 (668.0-903.5) |
| All other malignant neoplasms | 21 | 15.8 (9.6-24.5) | 48 | 19.9 (14.4-26.8) | 47 | 43.1 (30.7-58.4) | 116 | 23.9 (19.5-29.0) | 16.8 (13.9-20.1) |
| Leukemia | 7 | 5.3 (2.0-11.1) | 4 | 1.6 (0.3-4.3) | 0 | 11 | 2.3 (1.0-4.2) | 15.5 (7.7-27.7) | |
| All other hematopoietic | 3 | 2.3 (0.4-6.8) | 8 | 3.4 (1.4-6.8) | 10 | 9.7 (4.5-18.0) | 21 | 4.5 (2.7-6.9) | 42.5 (26.3-64.97) |
| Solid tumors | 11 | 8.2 (3.9-15.0 | 36 | 14.9 (10.2-21.0) | 37 | 33.6 (22.7-47.4) | 84 | 17.2 (13.4-21.5) | 14.9 (11.9-18.4) |
| Breast | 1 | 0.8 (0.0-4.3) | 9 | 3.8 (1.7-7.4) | 11 | 10.3 (4.9-18.9) | 21 | 4.4 (2.6-6.8) | 22.3 (13.8-34.1) |
| Buccal cavity/pharynx | 0 | 2 | 0.9 (0.1-3.2) | 0 | 2 | 0.4 (0.0-1.6) | 17.9 (2.01-64.5) | ||
| Lung/bronchus/trachea | 1 | 0.8 (0-4.3) | 4 | 1.7 (0.4-4.4) | 10 | 9.3 (4.2-17.6) | 15 | 3.1 (1.7-5.2) | 19.4 (10.9-32.0) |
| Digestive organs/peritoneum | 2 | 1.5 (0.1-5.6) | 10 | 4.2 (1.9-7.9) | 9 | 8.2 (3.4-16.2) | 21 | 4.4 (2.6-6.8) | 18.7 (11.6-28.6) |
| CNS | 2 | 1.5 (0.1-5.6) | 4 | 1.6 (0.4-4.4) | 1 | 0.8 (−0.2 to 5.3) | 7 | 1.4 (0.5-3.0) | 12.0 (4.89-24.6) |
| Kidney | 0 | 1 | 0.4 (0.0-2.4) | 0 | 1 | 0.2 (0.0-1.2) | 8.4 (0.1-46.8) | ||
| Melanoma | 1 | 0.8 (0-4.3) | 0 | 1 | 0.9 (−0.1 to 5.4) | 2 | 0.4 (0.0-1.5) | 6.3 (0.7-22.9) | |
| Others | 4 | 3.1 (0.8-7.9) | 6 | 2.5 (0.8-5.6) | 5 | 4.6 (1.3-11.2) | 15 | 3.1 (1.7-5.3) | 21.4 (12.0-35.3) |
| Benign neoplasms | 2 | 1.5 (0.1-5.6) | 1 | 0.4 (0-2.4) | 1 | 0.9 (0.0-5.5) | 4 | 0.8 (0.2-2.2) | 23.7 (6.4-60.6) |
| Cerebrovascular disease | 2 | 0.7 (0.1-3.0) | 3 | 2.4 (0.1-8.1) | 5 | 0.9 (0.1-2.3) | 4.6 (1.5-10.7) | ||
| All heart disease | 7 | 5.1 (1.8-10.9) | 30 | 12.3 (8.0-18.0) | 28 | 25.0 (15.7-37.3) | 65 | 13.1 (9.9-17.0) | 12.7 (9.8-16.2) |
| Ischemic heart disease | 4 | 3.1 (0.8-7.9) | 20 | 8.5 (5.1-13.3) | 13 | 11.4 (5.4-20.5) | 37 | 7.6 (5.2-10.7) | 16.5 (11.6-22.8) |
| Chronic endocardial, other myocardial insufficiency | 2 | 1.5 (0.2-5.6) | 5 | 2.1 (0.7-5.1) | 8 | 7.8 (3.3-15.5) | 15 | 3.2 (1.8-5.4) | 62.4 (34.9-102.92) |
| Nonmalignant respiratory disease | 5 | 3.7 (1.1-8.9) | 12 | 5.0 (2.4-8.9) | 5 | 4.4 (1.0-10.9) | 22 | 4.5 (2.7-7.0) | 14.2 (8.9-21.5) |
Cause of death not detailed in the table include external causes (n = 33), other (n = 40), and unknown causes (n = 44).
EAR indicates, excess absolute risk; SMR, standardized mortality ratio; PY indicates person-year; CI, confidence interval; and CNS, central nervous system.