Table 2 CI analysis of MCL cell lines... | American Society of Hematology

Table 2

CI analysis of MCL cell lines treated with MI-63 and dFdC

	Fold × IC₅₀ dFdC–MI-63
	0.25	0.50	1.0	2.0	4.0
Simultaneous addition
Granta-519	0.88*	0.88*	1.26	1.07	1.46
JVM-2	0.78*	0.73*	0.71*	0.81*	0.92
REC-1	0.33*	0.50*	0.93*	1.75	2.97
Pretreatment with MI-63, followed by dFdC
Granta-519	0.32*	0.30*	0.49*	0.71*	1.13
JVM-2	0.98*	0.64*	0.40*	0.51*	0.15*
REC-1	0.28*	0.43*	0.78*	1.43	2.54
Pretreatment with dFdC, followed by MI-63
Granta-519	0.41*	0.52*	0.91*	0.77*	0.97*
JVM-2	0.91*	0.70*	0.47*	0.12*	0.67*
REC-1	0.32*	0.54*	0.74*	1.38	2.46

	Fold × IC₅₀ dFdC–MI-63
	0.25	0.50	1.0	2.0	4.0
Simultaneous addition
Granta-519	0.88*	0.88*	1.26	1.07	1.46
JVM-2	0.78*	0.73*	0.71*	0.81*	0.92
REC-1	0.33*	0.50*	0.93*	1.75	2.97
Pretreatment with MI-63, followed by dFdC
Granta-519	0.32*	0.30*	0.49*	0.71*	1.13
JVM-2	0.98*	0.64*	0.40*	0.51*	0.15*
REC-1	0.28*	0.43*	0.78*	1.43	2.54
Pretreatment with dFdC, followed by MI-63
Granta-519	0.41*	0.52*	0.91*	0.77*	0.97*
JVM-2	0.91*	0.70*	0.47*	0.12*	0.67*
REC-1	0.32*	0.54*	0.74*	1.38	2.46

The indicated wtp53 MCL cell lines were incubated with MI-63 or dFdC alone, and their individual IC₅₀ values were determined. Interactions were determined using a 1:1 ratio of MI-63 to dFdC by simultaneous addition of both drugs or in a sequence-specific manner for 72 hours, and CI values calculated using a range of IC₅₀ values ranging from 0.25- to 4-fold the IC₅₀ value of each drug in each cell line.

Denotes a synergistic interaction.

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