Enriched functional annotation terms associated with top 96 genes
| Category . | Term . | % . | P* . | Genes . | Bonferroni* . |
|---|---|---|---|---|---|
| SP_PIR_KEYWORDS | Signal | 35.6 | < .0001 | OSMR, MMRN2, EMCN, C4orf7, DLAT, IL3RA, TACSTD1, SLIT3, ABI3BP, COL6A2, COL27A1, EGFL7, EPHA2, CD3E, DPT, PDIA2, CCL21, LDLR, COL12A1, ASAM, GFRA1, GPR124, CCL19, IGFBP3, PGF, TPO | 0.0018 |
| UP_SEQ_FEATURE | Signal peptide | 32.9 | < .0001 | ABI3BP, MMRN2, EMCN, COL6A2, COL27A1, C4orf7, EPHA2, EGFL7, DLAT, IL3RA, TACSTD1, CD3E, DPT, PDIA2, LDLR, CCL21, GFRA1, COL12A1, CCL19, GPR124, PGF, SLIT3, IGFBP3, TPO | 0.3724 |
| IPR008957 | Fibronectin, type III-like fold | 8.2 | .0004 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2, IL3RA | 0.9106 |
| GO:0009987 | Cellular process | 69.9 | .0018 | EXOC5, MAP1LC3C, DLAT, ADCY4, MSC, FOSL2, DGKZ, SLIT3, COL6A2, RASGRF1, MIOX, PIGA, NUAK2, GPR157, CCL21, LDLR, COL12A1, GPR124, IGFBP3, GFAP, OSMR, EMCN, IL3RA, PGS1, SORD, B3GNT3, DES, KIF21A, HOOK3, GOT2, MYH11, CSNK1G2, COL27A1, EGFL7, EPHA2, FOXG1, NPFFR2, CYB5R2, CD3E, DPT, CCND3, PDIA2, TGFB1I1, GJA4, SMAD3, GFRA1, CCL19, ZNF490, PGF, TPO, MRPL20 | 0.9999 |
| GO:0048513 | Organ development | 16.4 | .0028 | CD3E, MYH11, EMCN, PDLIM5, SMAD3, GJA4, COL12A1, PGF, FOXG1, EGFL7, IGFBP3, SLIT3 | 1.0000 |
| IPR003961 | Fibronectin, type III | 6.9 | .0037 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2 | 1.0000 |
| GO:0048731 | System development | 19.2 | .0041 | MYH11, EMCN, PDLIM5, EGFL7, EPHA2, FOXG1, CD3E, GJA4, SMAD3, COL12A1, GFRA1, PGF, SLIT3, IGFBP3 | 1.0000 |
| IPR001881 | EGF-like calcium-binding | 5.5 | .0055 | LDLR, EGFL7, SLIT3, TPO | 1.0000 |
| SM00060 | FN3 | 6.9 | .0059 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2 | 0.9731 |
| SP_PIR_KEYWORDS | Secreted | 16.4 | .0067 | DPT, MMRN2, EMCN, COL6A2, CCL21, COL12A1, C4orf7, CCL19, PGF, EGFL7, IGFBP3, SLIT3 | 0.9992 |
| GO:0044421 | Extracellular region part | 12.3 | .0077 | DPT, MMRN2, COL6A2, CCL21, COL27A1, COL12A1, CCL19, EGFL7, SLIT3 | 0.9988 |
| GO:0006519 | Amino acid and derivative Metabolic process | 8.2 | .0080 | GOT2, CD3E, CCND3, IGFBP3, DLAT, TPO | 1.0000 |
| SM00179 | EGF_CA | 5.5 | .0085 | LDLR, EGFL7, SLIT3, TPO | 0.9944 |
| GO:0005581 | Collagen | 4.1 | .0096 | COL6A2, COL27A1, COL12A1 | 0.9998 |
| Category . | Term . | % . | P* . | Genes . | Bonferroni* . |
|---|---|---|---|---|---|
| SP_PIR_KEYWORDS | Signal | 35.6 | < .0001 | OSMR, MMRN2, EMCN, C4orf7, DLAT, IL3RA, TACSTD1, SLIT3, ABI3BP, COL6A2, COL27A1, EGFL7, EPHA2, CD3E, DPT, PDIA2, CCL21, LDLR, COL12A1, ASAM, GFRA1, GPR124, CCL19, IGFBP3, PGF, TPO | 0.0018 |
| UP_SEQ_FEATURE | Signal peptide | 32.9 | < .0001 | ABI3BP, MMRN2, EMCN, COL6A2, COL27A1, C4orf7, EPHA2, EGFL7, DLAT, IL3RA, TACSTD1, CD3E, DPT, PDIA2, LDLR, CCL21, GFRA1, COL12A1, CCL19, GPR124, PGF, SLIT3, IGFBP3, TPO | 0.3724 |
| IPR008957 | Fibronectin, type III-like fold | 8.2 | .0004 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2, IL3RA | 0.9106 |
| GO:0009987 | Cellular process | 69.9 | .0018 | EXOC5, MAP1LC3C, DLAT, ADCY4, MSC, FOSL2, DGKZ, SLIT3, COL6A2, RASGRF1, MIOX, PIGA, NUAK2, GPR157, CCL21, LDLR, COL12A1, GPR124, IGFBP3, GFAP, OSMR, EMCN, IL3RA, PGS1, SORD, B3GNT3, DES, KIF21A, HOOK3, GOT2, MYH11, CSNK1G2, COL27A1, EGFL7, EPHA2, FOXG1, NPFFR2, CYB5R2, CD3E, DPT, CCND3, PDIA2, TGFB1I1, GJA4, SMAD3, GFRA1, CCL19, ZNF490, PGF, TPO, MRPL20 | 0.9999 |
| GO:0048513 | Organ development | 16.4 | .0028 | CD3E, MYH11, EMCN, PDLIM5, SMAD3, GJA4, COL12A1, PGF, FOXG1, EGFL7, IGFBP3, SLIT3 | 1.0000 |
| IPR003961 | Fibronectin, type III | 6.9 | .0037 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2 | 1.0000 |
| GO:0048731 | System development | 19.2 | .0041 | MYH11, EMCN, PDLIM5, EGFL7, EPHA2, FOXG1, CD3E, GJA4, SMAD3, COL12A1, GFRA1, PGF, SLIT3, IGFBP3 | 1.0000 |
| IPR001881 | EGF-like calcium-binding | 5.5 | .0055 | LDLR, EGFL7, SLIT3, TPO | 1.0000 |
| SM00060 | FN3 | 6.9 | .0059 | ABI3BP, OSMR, FNDC1, COL12A1, EPHA2 | 0.9731 |
| SP_PIR_KEYWORDS | Secreted | 16.4 | .0067 | DPT, MMRN2, EMCN, COL6A2, CCL21, COL12A1, C4orf7, CCL19, PGF, EGFL7, IGFBP3, SLIT3 | 0.9992 |
| GO:0044421 | Extracellular region part | 12.3 | .0077 | DPT, MMRN2, COL6A2, CCL21, COL27A1, COL12A1, CCL19, EGFL7, SLIT3 | 0.9988 |
| GO:0006519 | Amino acid and derivative Metabolic process | 8.2 | .0080 | GOT2, CD3E, CCND3, IGFBP3, DLAT, TPO | 1.0000 |
| SM00179 | EGF_CA | 5.5 | .0085 | LDLR, EGFL7, SLIT3, TPO | 0.9944 |
| GO:0005581 | Collagen | 4.1 | .0096 | COL6A2, COL27A1, COL12A1 | 0.9998 |
P value and Bonferroni were provided by DAVID bioinformatics resources.