Down-regulated genes in PCNSL
| PCNSL versus normal LN (present study) . | PCNSL versus non-CNS DLBCL . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Probe ID . | Gene . | P (FWER) . | Rank . | Probe ID . | Gene . | P (FWER) . | Rank . | Gene by Tun et al6 . | Gene by Rubenstein et al7 . |
| A_23_P140190 | FAM30A | .001 | 2 | A_32_P167239 | AFAP1L1 | .029 | 56 | CX3CR1 | ZFP36 |
| A_24_P95723 | KIAA0125 | .001 | 3 | A_23_P43283 | GPR124 | .030 | 57 | AK091178 | MLL |
| A_24_P70183 | MYH11 | .002 | 5 | A_32_P76137 | Not found | .030 | 58 | D42043 | CHES1 |
| A_24_P76868 | Not found | .002 | 6 | A_24_P375761 | STGC3 | .030 | 59 | SQLE | EPHB3 |
| A_23_P206920 | MYH11 | .006 | 9 | A_24_P110618 | Not found | .030 | 60 | P2RY8 | RPS6KA3 |
| A_23_P76992 | PGF | .008 | 11 | A_23_P90710 | DES | .030 | 62 | LXN | DDR2 |
| A_24_P52697 | H19 | .008 | 12 | A_23_P218858 | ABI3BP | .031 | 63 | LPP | ADAM12 |
| A_23_P123853 | CCL19 | .008 | 13 | A_23_P310956 | COL6A2 | .031 | 64 | S56205 | MMP2 |
| A_24_P183128 | PLAC8 | .008 | 15 | A_23_P382065 | EMCN | .031 | 65 | Z24727 | COL4A2 |
| A_32_P172320 | CCND3 | .009 | 16 | A_24_P270044 | ASAM | .031 | 66 | STEAP | COL5A1 |
| A_32_P145968 | Not found | .011 | 18 | A_24_P99963 | CSNK1G2 | .032 | 68 | COL6A1 | VCAM1 |
| A_23_P78980 | B3GNT3 | .011 | 19 | A_23_P112470 | CCL21 | .032 | 69 | COL12A1 | CDH1 |
| A_23_P200741 | DPT | .012 | 21 | A_24_P86968 | CD3E | .032 | 70 | AK022110 | ITGAX |
| A_32_P444104 | LOC284454 | .015 | 24 | A_23_P158096 | COL27A1 | .032 | 71 | NR2F2 | |
| A_23_P45821 | Not found | .015 | 25 | A_24_P15062 | ZNF490 | .033 | 72 | NNMT | |
| A_23_P12686 | GFRA1 | .015 | 27 | A_24_P257224 | TPO | .033 | 74 | AK091153 | |
| A_23_P81219 | PLAC8 | .016 | 28 | A_23_P150064 | MMRN2 | .035 | 75 | BC040354 | |
| A_23_P149281 | EPHA2 | .016 | 30 | A_24_P361816 | IGLV6–57 | .038 | 76 | VEGFC | |
| A_23_P345581 | FOSL2 | .018 | 32 | A_23_P407840 | FNDC1 | .038 | 77 | LAMA4 | |
| A_23_P155900 | NPFFR2 | .018 | 33 | A_24_P101642 | LOC401847 | .042 | 80 | NM_015714 | |
| A_23_P381261 | ADCY4 | .020 | 34 | A_23_P215634 | IGFBP3 | .042 | 81 | CAMKK2 | |
| A_23_P96955 | FAM167B | .022 | 35 | A_23_P43276 | GPR124 | .043 | 83 | FBN1 | |
| A_23_P362694 | C4orf7 | .022 | 36 | A_32_P12454 | Not found | .043 | 84 | AJ001381 | |
| A_24_P788878 | FAM148B | .023 | 37 | A_24_P324787 | KANK2 | .043 | 85 | LUM | |
| A_23_P48936 | SMAD3 | .024 | 39 | A_23_P52161 | NUAK2 | .043 | 86 | LOXL1 | |
| A_24_P940288 | PGS1 | .024 | 40 | A_23_P208595 | LDLR | .043 | 87 | COL1A2 | |
| A_23_P215634 | IGFBP3 | .024 | 41 | A_23_P48936 | SMAD3 | .043 | 88 | ||
| A_23_P48936 | SMAD3 | .025 | 43 | A_23_P214168 | COL12A1 | .045 | 90 | ||
| A_24_P71280 | GPR157 | .026 | 44 | A_24_P216456 | MAP1LC3C | .045 | 91 | ||
| A_24_P207907 | R3HDM2 | .026 | 47 | A_23_P209799 | MYO7B | .046 | 92 | ||
| A_23_P156289 | OSMR | .026 | 49 | A_23_P127627 | DGKZ | .047 | 93 | ||
| A_23_P407695 | FAM151A | .027 | 51 | A_32_P210642 | EGFL7 | .047 | 94 | ||
| A_23_P1083 | GJA4 | .027 | 53 | A_23_P141055 | TGFB1I1 | .047 | 95 | ||
| A_32_P217750 | IL3RA | .027 | 54 | A_23_P256948 | MSC | .048 | 96 | ||
| A_23_P58588 | SLIT3 | .028 | 55 | ||||||
| PCNSL versus normal LN (present study) . | PCNSL versus non-CNS DLBCL . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Probe ID . | Gene . | P (FWER) . | Rank . | Probe ID . | Gene . | P (FWER) . | Rank . | Gene by Tun et al6 . | Gene by Rubenstein et al7 . |
| A_23_P140190 | FAM30A | .001 | 2 | A_32_P167239 | AFAP1L1 | .029 | 56 | CX3CR1 | ZFP36 |
| A_24_P95723 | KIAA0125 | .001 | 3 | A_23_P43283 | GPR124 | .030 | 57 | AK091178 | MLL |
| A_24_P70183 | MYH11 | .002 | 5 | A_32_P76137 | Not found | .030 | 58 | D42043 | CHES1 |
| A_24_P76868 | Not found | .002 | 6 | A_24_P375761 | STGC3 | .030 | 59 | SQLE | EPHB3 |
| A_23_P206920 | MYH11 | .006 | 9 | A_24_P110618 | Not found | .030 | 60 | P2RY8 | RPS6KA3 |
| A_23_P76992 | PGF | .008 | 11 | A_23_P90710 | DES | .030 | 62 | LXN | DDR2 |
| A_24_P52697 | H19 | .008 | 12 | A_23_P218858 | ABI3BP | .031 | 63 | LPP | ADAM12 |
| A_23_P123853 | CCL19 | .008 | 13 | A_23_P310956 | COL6A2 | .031 | 64 | S56205 | MMP2 |
| A_24_P183128 | PLAC8 | .008 | 15 | A_23_P382065 | EMCN | .031 | 65 | Z24727 | COL4A2 |
| A_32_P172320 | CCND3 | .009 | 16 | A_24_P270044 | ASAM | .031 | 66 | STEAP | COL5A1 |
| A_32_P145968 | Not found | .011 | 18 | A_24_P99963 | CSNK1G2 | .032 | 68 | COL6A1 | VCAM1 |
| A_23_P78980 | B3GNT3 | .011 | 19 | A_23_P112470 | CCL21 | .032 | 69 | COL12A1 | CDH1 |
| A_23_P200741 | DPT | .012 | 21 | A_24_P86968 | CD3E | .032 | 70 | AK022110 | ITGAX |
| A_32_P444104 | LOC284454 | .015 | 24 | A_23_P158096 | COL27A1 | .032 | 71 | NR2F2 | |
| A_23_P45821 | Not found | .015 | 25 | A_24_P15062 | ZNF490 | .033 | 72 | NNMT | |
| A_23_P12686 | GFRA1 | .015 | 27 | A_24_P257224 | TPO | .033 | 74 | AK091153 | |
| A_23_P81219 | PLAC8 | .016 | 28 | A_23_P150064 | MMRN2 | .035 | 75 | BC040354 | |
| A_23_P149281 | EPHA2 | .016 | 30 | A_24_P361816 | IGLV6–57 | .038 | 76 | VEGFC | |
| A_23_P345581 | FOSL2 | .018 | 32 | A_23_P407840 | FNDC1 | .038 | 77 | LAMA4 | |
| A_23_P155900 | NPFFR2 | .018 | 33 | A_24_P101642 | LOC401847 | .042 | 80 | NM_015714 | |
| A_23_P381261 | ADCY4 | .020 | 34 | A_23_P215634 | IGFBP3 | .042 | 81 | CAMKK2 | |
| A_23_P96955 | FAM167B | .022 | 35 | A_23_P43276 | GPR124 | .043 | 83 | FBN1 | |
| A_23_P362694 | C4orf7 | .022 | 36 | A_32_P12454 | Not found | .043 | 84 | AJ001381 | |
| A_24_P788878 | FAM148B | .023 | 37 | A_24_P324787 | KANK2 | .043 | 85 | LUM | |
| A_23_P48936 | SMAD3 | .024 | 39 | A_23_P52161 | NUAK2 | .043 | 86 | LOXL1 | |
| A_24_P940288 | PGS1 | .024 | 40 | A_23_P208595 | LDLR | .043 | 87 | COL1A2 | |
| A_23_P215634 | IGFBP3 | .024 | 41 | A_23_P48936 | SMAD3 | .043 | 88 | ||
| A_23_P48936 | SMAD3 | .025 | 43 | A_23_P214168 | COL12A1 | .045 | 90 | ||
| A_24_P71280 | GPR157 | .026 | 44 | A_24_P216456 | MAP1LC3C | .045 | 91 | ||
| A_24_P207907 | R3HDM2 | .026 | 47 | A_23_P209799 | MYO7B | .046 | 92 | ||
| A_23_P156289 | OSMR | .026 | 49 | A_23_P127627 | DGKZ | .047 | 93 | ||
| A_23_P407695 | FAM151A | .027 | 51 | A_32_P210642 | EGFL7 | .047 | 94 | ||
| A_23_P1083 | GJA4 | .027 | 53 | A_23_P141055 | TGFB1I1 | .047 | 95 | ||
| A_32_P217750 | IL3RA | .027 | 54 | A_23_P256948 | MSC | .048 | 96 | ||
| A_23_P58588 | SLIT3 | .028 | 55 | ||||||
LN indicates lymph node.