Correlation analysis of different biochemical and physiologic parameters with Cp activity
. | Cp activity . | Cp mRNA . | Cp protein . | Liver iron, ppm . | Serum iron, μg/dL . | Liver copper, ppm . | Serum copper, ppm . | Hb, g/dL . | Hct, % . |
---|---|---|---|---|---|---|---|---|---|
Ctrl | 1a | 1 | 1a | 376.6a | 331.8a | 10.7a,c,d | 0.46a | 13.1a | 46a |
CuE | 1.80b | 0.89 | 1.26a,b | 379.6a | 312.8a | 17.1d | 0.76b | 13.4a | 49a |
FeD | 1.89b,c | 1.41 | 1.52b | 63.3b | 33.6b | 15.3a,d | 0.65b | 3.3b | 15b |
FeDCuE | 2.20c | 1.72 | 1.53b | 76.7b | 64.4b | 30.6b | 0.79b | 6.6c | 31c |
CuD | 0.04d | 2.30 | 0.15c | 578c | 165c | 3.56c | 0.03c | 5.3d | 22d |
FeDCuD | −0.04d | 1.31 | 0.16c | 85.5b | 33.13b | 3.03a,c | 0.02c | 2.5b | 13b |
Correlation with Cp activity | NA | 0.02 | 0.74* | −0.39 | 0.05 | 0.83* | 0.95* | 0.29 | 0.33 |
Significance (2-tailed) | .901 | < .0001 | .008 | .736 | < .0001 | < .0001 | .05 | .025 |
. | Cp activity . | Cp mRNA . | Cp protein . | Liver iron, ppm . | Serum iron, μg/dL . | Liver copper, ppm . | Serum copper, ppm . | Hb, g/dL . | Hct, % . |
---|---|---|---|---|---|---|---|---|---|
Ctrl | 1a | 1 | 1a | 376.6a | 331.8a | 10.7a,c,d | 0.46a | 13.1a | 46a |
CuE | 1.80b | 0.89 | 1.26a,b | 379.6a | 312.8a | 17.1d | 0.76b | 13.4a | 49a |
FeD | 1.89b,c | 1.41 | 1.52b | 63.3b | 33.6b | 15.3a,d | 0.65b | 3.3b | 15b |
FeDCuE | 2.20c | 1.72 | 1.53b | 76.7b | 64.4b | 30.6b | 0.79b | 6.6c | 31c |
CuD | 0.04d | 2.30 | 0.15c | 578c | 165c | 3.56c | 0.03c | 5.3d | 22d |
FeDCuD | −0.04d | 1.31 | 0.16c | 85.5b | 33.13b | 3.03a,c | 0.02c | 2.5b | 13b |
Correlation with Cp activity | NA | 0.02 | 0.74* | −0.39 | 0.05 | 0.83* | 0.95* | 0.29 | 0.33 |
Significance (2-tailed) | .901 | < .0001 | .008 | .736 | < .0001 | < .0001 | .05 | .025 |
Different letters indicate statistical differences between groups (1-way ANOVA followed by Tukey multiple comparison test; P < .05). Values are means for each parameter.
NA indicates not applicable.
Pearson correlation coefficient (r) values with a strong positive correlation.