Table 2

Correlation analysis of different biochemical and physiologic parameters with Cp activity

Cp activityCp mRNACp proteinLiver iron, ppmSerum iron, μg/dLLiver copper, ppmSerum copper, ppmHb, g/dLHct, %
Ctrl 1a 1a 376.6a 331.8a 10.7a,c,d 0.46a 13.1a 46a 
CuE 1.80b 0.89 1.26a,b 379.6a 312.8a 17.1d 0.76b 13.4a 49a 
FeD 1.89b,c 1.41 1.52b 63.3b 33.6b 15.3a,d 0.65b 3.3b 15b 
FeDCuE 2.20c 1.72 1.53b 76.7b 64.4b 30.6b 0.79b 6.6c 31c 
CuD 0.04d 2.30 0.15c 578c 165c 3.56c 0.03c 5.3d 22d 
FeDCuD −0.04d 1.31 0.16c 85.5b 33.13b 3.03a,c 0.02c 2.5b 13b 
Correlation with Cp activity NA 0.02 0.74* −0.39 0.05 0.83* 0.95* 0.29 0.33 
Significance (2-tailed)  .901 < .0001 .008 .736 < .0001 < .0001 .05 .025 
Cp activityCp mRNACp proteinLiver iron, ppmSerum iron, μg/dLLiver copper, ppmSerum copper, ppmHb, g/dLHct, %
Ctrl 1a 1a 376.6a 331.8a 10.7a,c,d 0.46a 13.1a 46a 
CuE 1.80b 0.89 1.26a,b 379.6a 312.8a 17.1d 0.76b 13.4a 49a 
FeD 1.89b,c 1.41 1.52b 63.3b 33.6b 15.3a,d 0.65b 3.3b 15b 
FeDCuE 2.20c 1.72 1.53b 76.7b 64.4b 30.6b 0.79b 6.6c 31c 
CuD 0.04d 2.30 0.15c 578c 165c 3.56c 0.03c 5.3d 22d 
FeDCuD −0.04d 1.31 0.16c 85.5b 33.13b 3.03a,c 0.02c 2.5b 13b 
Correlation with Cp activity NA 0.02 0.74* −0.39 0.05 0.83* 0.95* 0.29 0.33 
Significance (2-tailed)  .901 < .0001 .008 .736 < .0001 < .0001 .05 .025 

Different letters indicate statistical differences between groups (1-way ANOVA followed by Tukey multiple comparison test; P < .05). Values are means for each parameter.

NA indicates not applicable.

*

Pearson correlation coefficient (r) values with a strong positive correlation.

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