Table 3 OR and 95% CIs for previously... | American Society of Hematology

Table 3

OR and 95% CIs for previously reported CLL susceptibility loci

Previously reported		Current study SNP	(r²)*	Position	Risk Allele	Number of subjects		Minor allele frequency		OR	95% CI		P
Locus	SNP	Same or best tag	(r²)*	Position	Risk Allele	Cases	Controls	Cases	Controls	OR	95% CI		P
2q13	rs17483466	rs17483466		111513929	G	659	1261	0.26	0.22	1.27	1.09	1.48	2.03 × 10⁻³
2q37.1	rs13397985	rs13397985		230799467	G	659	1261	0.26	0.20	1.33	1.13	1.55	2.79 × 10⁻⁴
2q37.3	rs757978†	rs757978		242019774	T	407	296	0.12	0.09	1.46	1.02	2.08	3.90 × 10⁻²
6p25	rs872071‡	rs872071		356064	G	252	965	0.58	0.52	1.30	1.06	1.59	8.72 × 10⁻³
	rs9378805	rs9378805		362727	C	659	1261	0.57	0.49	1.38	1.20	1.58	1.59 × 10⁻⁶
8q24.21	rs2456449†	rs1021955	0.87	128273155	G	407	296	0.45	0.37	1.37	1.10	1.70	5.24 × 10⁻³
11q24	rs735665§	rs735665		122866607	T	407	296	0.28	0.21	1.47	1.14	1.89	2.64 × 10⁻³
15q21.3	rs7169431†	rs7169431		54128188	A	407	296	0.12	0.09	1.33	0.94	1.87	1.07 × 10⁻¹
15q23	rs7176508‡	rs7176508		67806044	A	252	965	0.50	0.41	1.40	1.15	1.70	4.74 × 10⁻⁴
16q24.1	rs305061†	rs305065	0.93	84531367	C	407	296	0.29	0.35	0.77	0.61	0.97	2.37 × 10⁻²
19q13	rs11083846‡	rs11083846		51899494	A	252	965	0.21	0.22	0.92	0.72	1.17	4.98 × 10⁻¹

Previously reported		Current study SNP	(r²)*	Position	Risk Allele	Number of subjects		Minor allele frequency		OR	95% CI		P
Locus	SNP	Same or best tag	(r²)*	Position	Risk Allele	Cases	Controls	Cases	Controls	OR	95% CI		P
2q13	rs17483466	rs17483466		111513929	G	659	1261	0.26	0.22	1.27	1.09	1.48	2.03 × 10⁻³
2q37.1	rs13397985	rs13397985		230799467	G	659	1261	0.26	0.20	1.33	1.13	1.55	2.79 × 10⁻⁴
2q37.3	rs757978†	rs757978		242019774	T	407	296	0.12	0.09	1.46	1.02	2.08	3.90 × 10⁻²
6p25	rs872071‡	rs872071		356064	G	252	965	0.58	0.52	1.30	1.06	1.59	8.72 × 10⁻³
	rs9378805	rs9378805		362727	C	659	1261	0.57	0.49	1.38	1.20	1.58	1.59 × 10⁻⁶
8q24.21	rs2456449†	rs1021955	0.87	128273155	G	407	296	0.45	0.37	1.37	1.10	1.70	5.24 × 10⁻³
11q24	rs735665§	rs735665		122866607	T	407	296	0.28	0.21	1.47	1.14	1.89	2.64 × 10⁻³
15q21.3	rs7169431†	rs7169431		54128188	A	407	296	0.12	0.09	1.33	0.94	1.87	1.07 × 10⁻¹
15q23	rs7176508‡	rs7176508		67806044	A	252	965	0.50	0.41	1.40	1.15	1.70	4.74 × 10⁻⁴
16q24.1	rs305061†	rs305065	0.93	84531367	C	407	296	0.29	0.35	0.77	0.61	0.97	2.37 × 10⁻²
19q13	rs11083846‡	rs11083846		51899494	A	252	965	0.21	0.22	0.92	0.72	1.17	4.98 × 10⁻¹

OR indicates odds ratio; and CI, confidence interval.

r² is between published SNP and most correlated SNP in study based on HapMap CEU.

SNPs genotyped only in discovery cohort.

SNPs genotyped only in replication cohort.

SNP failed genotyping in replication cohort.