Table 2

Associations of CLL risk with replicated SNPs among familial CLL cases

LocusNearest geneSNPPositionRisk alleleStageNumber of subjects
Minor allele frequency
OR95% CIP
CasesControlsCasesControls
6p21.3 HLA-DRB5 rs615672 32682149 C Discovery 102 296 0.50 0.34 1.95 1.40 2.73 6.42 × 10−5 
     Replication 252 965 0.47 0.39 1.31 1.09 1.57 2.85 × 10−3 
     Combined* 354 1261 0.48 0.38 1.42 1.22 1.67 1.29 × 10−5 
     Combined independent† 198 794 0.47 0.36 1.46 1.19 1.81 3.40 × 10−4 
  rs674313 32686060 T Discovery 102 296 0.44 0.26 2.40 1.67 3.45 1.12 × 10−6 
     Replication 252 965 0.35 0.26 1.50 1.22 1.84 6.90 × 10−5 
     Combined* 354 1261 0.38 0.26 1.69 1.41 2.01 6.92 × 10−9 
     Combined independent† 198 794 0.38 0.25 1.87 1.47 2.38 1.98 × 10−7 
  rs502771 32686948 C Discovery 102 296 0.43 0.28 1.93 1.37 2.70 1.07 × 10−4 
     Replication 252 965 0.38 0.28 1.51 1.23 1.84 3.28 × 10−5 
     Combined* 354 1261 0.40 0.28 1.61 1.36 1.91 5.58 × 10−8 
     Combined independent† 198 794 0.39 0.27 1.68 1.33 2.11 8.17 × 10−6 
 HLA-DQA1 rs9272219 32710247 T Discovery 102 296 0.44 0.26 2.32 1.62 3.30 1.65 × 10−6 
     Replication 252 965 0.35 0.27 1.40 1.14 1.71 9.46 × 10−4 
     Combined* 354 1261 0.38 0.27 1.59 1.34 1.90 1.84 × 10−7 
     Combined independent† 198 794 0.38 0.27 1.71 1.36 2.17 4.55 × 10−6 
  rs9272535 32714734 A Discovery 102 296 0.44 0.26 2.33 1.64 3.32 1.33 × 10−6 
     Replication 252 965 0.35 0.27 1.42 1.15 1.74 5.96 × 10−4 
     Combined* 354 1261 0.38 0.27 1.61 1.35 1.92 9.31 × 10−8 
     Combined independent† 198 794 0.38 0.26 1.75 1.38 2.21 2.25 × 10−6 
LocusNearest geneSNPPositionRisk alleleStageNumber of subjects
Minor allele frequency
OR95% CIP
CasesControlsCasesControls
6p21.3 HLA-DRB5 rs615672 32682149 C Discovery 102 296 0.50 0.34 1.95 1.40 2.73 6.42 × 10−5 
     Replication 252 965 0.47 0.39 1.31 1.09 1.57 2.85 × 10−3 
     Combined* 354 1261 0.48 0.38 1.42 1.22 1.67 1.29 × 10−5 
     Combined independent† 198 794 0.47 0.36 1.46 1.19 1.81 3.40 × 10−4 
  rs674313 32686060 T Discovery 102 296 0.44 0.26 2.40 1.67 3.45 1.12 × 10−6 
     Replication 252 965 0.35 0.26 1.50 1.22 1.84 6.90 × 10−5 
     Combined* 354 1261 0.38 0.26 1.69 1.41 2.01 6.92 × 10−9 
     Combined independent† 198 794 0.38 0.25 1.87 1.47 2.38 1.98 × 10−7 
  rs502771 32686948 C Discovery 102 296 0.43 0.28 1.93 1.37 2.70 1.07 × 10−4 
     Replication 252 965 0.38 0.28 1.51 1.23 1.84 3.28 × 10−5 
     Combined* 354 1261 0.40 0.28 1.61 1.36 1.91 5.58 × 10−8 
     Combined independent† 198 794 0.39 0.27 1.68 1.33 2.11 8.17 × 10−6 
 HLA-DQA1 rs9272219 32710247 T Discovery 102 296 0.44 0.26 2.32 1.62 3.30 1.65 × 10−6 
     Replication 252 965 0.35 0.27 1.40 1.14 1.71 9.46 × 10−4 
     Combined* 354 1261 0.38 0.27 1.59 1.34 1.90 1.84 × 10−7 
     Combined independent† 198 794 0.38 0.27 1.71 1.36 2.17 4.55 × 10−6 
  rs9272535 32714734 A Discovery 102 296 0.44 0.26 2.33 1.64 3.32 1.33 × 10−6 
     Replication 252 965 0.35 0.27 1.42 1.15 1.74 5.96 × 10−4 
     Combined* 354 1261 0.38 0.27 1.61 1.35 1.92 9.31 × 10−8 
     Combined independent† 198 794 0.38 0.26 1.75 1.38 2.21 2.25 × 10−6 

OR indicates odds ratio; and CI, confidence interval.

*

All available familial CLL cases from 198 CLL families and controls from both stages.

†

All unrelated familial CLL cases from 198 CLL families and controls from both stages.

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