Table 1 Associations of CLL risk with... | American Society of Hematology

Table 1

Associations of CLL risk with replicated SNPs among all CLL cases

Locus	Nearest gene	SNP	Position	Risk allele	Stage	Number of subjects		Minor allele frequency		OR	95% CI		P
Locus	Nearest gene	SNP	Position	Risk allele	Stage	Cases	Controls	Cases	Controls	OR	95% CI		P
16q24.1	IRF8	rs305077	84500967	C	Discovery	407	296	0.26	0.38	0.57	0.45	0.73	2.75 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.68	0.55	0.85	5.62 × 10⁻⁴
					Combined*	659	1261	0.26	0.34	0.66	0.57	0.77	3.37 × 10⁻⁸
					Combined independent†	503	794	0.25	0.37	0.57	0.48	0.69	5.91 × 10⁻¹⁰
		rs391525	84501940	G	Discovery	407	296	0.25	0.38	0.54	0.43	0.69	5.00 × 10⁻⁷
					Replication	252	965	0.25	0.33	0.67	0.53	0.84	2.80 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.64	0.55	0.74	3.16 × 10⁻⁹
					Combined independent†	503	794	0.25	0.37	0.55	0.46	0.66	6.94 × 10⁻¹¹
		rs2292982	84502324	G	Discovery	407	296	0.26	0.38	0.56	0.44	0.71	1.08 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.66	0.52	0.82	1.79 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.65	0.56	0.75	6.48 × 10⁻⁹
					Combined independent†	503	794	0.25	0.37	0.56	0.47	0.68	2.13 × 10⁻¹⁰
		rs2292980	84502577	C	Discovery	407	296	0.26	0.38	0.57	0.45	0.72	1.90 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.67	0.53	0.84	3.02 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.66	0.56	0.76	1.89 × 10⁻⁸
					Combined independent†	503	794	0.25	0.37	0.57	0.48	0.69	6.34 × 10⁻¹⁰

Locus	Nearest gene	SNP	Position	Risk allele	Stage	Number of subjects		Minor allele frequency		OR	95% CI		P
Locus	Nearest gene	SNP	Position	Risk allele	Stage	Cases	Controls	Cases	Controls	OR	95% CI		P
16q24.1	IRF8	rs305077	84500967	C	Discovery	407	296	0.26	0.38	0.57	0.45	0.73	2.75 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.68	0.55	0.85	5.62 × 10⁻⁴
					Combined*	659	1261	0.26	0.34	0.66	0.57	0.77	3.37 × 10⁻⁸
					Combined independent†	503	794	0.25	0.37	0.57	0.48	0.69	5.91 × 10⁻¹⁰
		rs391525	84501940	G	Discovery	407	296	0.25	0.38	0.54	0.43	0.69	5.00 × 10⁻⁷
					Replication	252	965	0.25	0.33	0.67	0.53	0.84	2.80 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.64	0.55	0.74	3.16 × 10⁻⁹
					Combined independent†	503	794	0.25	0.37	0.55	0.46	0.66	6.94 × 10⁻¹¹
		rs2292982	84502324	G	Discovery	407	296	0.26	0.38	0.56	0.44	0.71	1.08 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.66	0.52	0.82	1.79 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.65	0.56	0.75	6.48 × 10⁻⁹
					Combined independent†	503	794	0.25	0.37	0.56	0.47	0.68	2.13 × 10⁻¹⁰
		rs2292980	84502577	C	Discovery	407	296	0.26	0.38	0.57	0.45	0.72	1.90 × 10⁻⁶
					Replication	252	965	0.25	0.33	0.67	0.53	0.84	3.02 × 10⁻⁴
					Combined*	659	1261	0.25	0.34	0.66	0.56	0.76	1.89 × 10⁻⁸
					Combined independent†	503	794	0.25	0.37	0.57	0.48	0.69	6.34 × 10⁻¹⁰

OR indicates odds ratio; and CI, confidence interval.

All cases and controls (related and unrelated) from both stages.

All unrelated cases and controls from both stages.